Lee, Soohyun Kang, Jin U.
Published in
Journal of Biomedical Optics
Significance: Subretinal injection is an effective way of delivering transplant genes and cells to treat many degenerative retinal diseases. However, the technique requires high-dexterity and microscale precision of experienced surgeons, who have to overcome the physiological hand tremor and limited visualization of the subretinal space. Aim: To au...
Yao, Junjie Wang, Lihong V.
Published in
Journal of Biomedical Optics
Significance: Acoustically detecting the rich optical absorption contrast in biological tissues, photoacoustic tomography (PAT) seamlessly bridges the functional and molecular sensitivity of optical excitation with the deep penetration and high scalability of ultrasound detection. As a result of continuous technological innovations and commercial d...
Ramella-Roman, Jessica Gandjbakhche, Amir H. Kanick, Stephen C. Shadgan, Babak Tromberg, Bruce J.
Published in
Journal of Biomedical Optics
Guest editors Jessica Ramella-Roman, Amir H. Gandjbakhche, Stephen C. Kanick, Babak Shadgan, and Bruce J. Tromberg introduce and summarize the articles included in the 6-part JBO Special Section on Wearable, Implantable, Mobile, and Remote Biomedical Optics Photonics.
Vasudevan, Sandhya Campbell, Chris Liu, Fang O’Sullivan, Thomas D.
Published in
Journal of Biomedical Optics
Significance: Noninvasive diffuse optical spectroscopy (DOS) is a promising adjunct diagnostic imaging technique for distinguishing benign and malignant breast lesions. Most DOS approaches require normalizing lesion biomarkers to healthy tissue since major tissue constituents exhibit large interpatient variations. However, absolute optical biomarke...
Martell, Matthew T. Haven, Nathaniel J. M. Zemp, Roger J.
Published in
Journal of Biomedical Optics
Significance: Spectral-domain optical coherence tomography (SD-OCT) offers depth-resolved imaging of optical scattering contrast but is limited in sensitivity to optical absorption. Dual-modality imaging combined with the noncontact absorption contrast of photoacoustic remote sensing (PARS) microscopy can augment SD-OCT applications with specific m...
Song, Bofan Sunny, Sumsum Li, Shaobai Gurushanth, Keerthi Mendonca, Pramila Mukhia, Nirza Patrick, Sanjana Gurudath, Shubha Raghavan, Subhashini Imchen, Tsusennaro
...
Published in
Journal of Biomedical Optics
Significance: Oral cancer is among the most common cancers globally, especially in low- and middle-income countries. Early detection is the most effective way to reduce the mortality rate. Deep learning-based cancer image classification models usually need to be hosted on a computing server. However, internet connection is unreliable for screening ...
Tilbury, Karissa Han, XiangHua Brooks, Peter C. Khalil, Andre
Published in
Journal of Biomedical Optics
Significance: Morphological collagen signatures are important for tissue function, particularly in the tumor microenvironment. A single algorithmic framework with quantitative, multiscale morphological collagen feature extraction may further the use of collagen signatures in understanding fundamental tumor progression. Aim: A modification of the 2D...
James, Darian S. Brereton, Christopher J. Davies, Donna E. Jones, Mark G. Campagnola, Paul J.
Published in
Journal of Biomedical Optics
Significance: Idiopathic pulmonary fibrosis (IPF) patients have a poor prognosis with short lifespan following diagnosis as there are limited effective treatment options. Despite matrix stiffening being the hallmark of the disease there remains a lack of knowledge surrounding the underlying collagen alterations in the disease. Specifically, while i...
Gómez-Valverde, Juan J. Sinz, Christoph Rank, Elisabet A. Chen, Zhe Santos, Andrés Drexler, Wolfgang Ledesma-Carbayo, María J.
Published in
Journal of Biomedical Optics
Significance: Speckle noise limits the diagnostic capabilities of optical coherence tomography (OCT) images, causing both a reduction in contrast and a less accurate assessment of the microstructural morphology of the tissue. Aim: We present a speckle-noise reduction method for OCT volumes that exploits the advantages of adaptive-noise wavelet thre...
Bancelin, Stéphane Mercier, Luc Murana, Emanuele Nägerl, U. Valentin
Published in
Neurophotonics
Significance: Stimulated emission depletion (STED) microscopy enables nanoscale imaging of live samples, but it requires a specific spatial beam shaping that is highly sensitive to optical aberrations, limiting its depth penetration. Therefore, there is a need for methods to reduce optical aberrations and improve the spatial resolution of STED micr...
