Alfonso-García, Alba Zhou, Xiangnan Bec, Julien Anbunesan, Silvia N. Fereidouni, Farzad Jin, Lee-Way Lee, Han S. Bloch, Orin Marcu, Laura
Published in
Journal of Biomedical Optics
Significance: 5-aminolevulinic acid (5-ALA)-induced protoporphyrin IX (PpIX) fluorescence is currently used for image-guided glioma resection. Typically, this widefield imaging method highlights the bulk of high-grade gliomas, but it underperforms at the infiltrating edge where PpIX fluorescence is not visible to the eyes. Fluorescence lifetime ima...
Zhao, Fangzhou Levoni, Pietro Frabasile, Lorenzo Qi, Hong Lacerenza, Michele Lanka, Pranav Torricelli, Alessandro Pifferi, Antonio Cubeddu, Rinaldo Spinelli, Lorenzo
...
Published in
Journal of Biomedical Optics
Significance: Tissue-like solid phantoms with identical optical properties, known within tolerant uncertainty, are of crucial importance in diffuse optics for instrumentation assessment, interlaboratory comparison studies, industrial standards, and multicentric clinical trials. Aim: The reproducibility in fabrication of homogeneous solid phantoms i...
Gkouzionis, Ioannis Nazarian, Scarlet Kawka, Michal Darzi, Ara Patel, Nisha Peters, Christopher J. Elson, Daniel S.
Published in
Journal of Biomedical Optics
Significance: Diffuse reflectance spectroscopy (DRS) allows discrimination of tissue type. Its application is limited by the inability to mark the scanned tissue and the lack of real-time measurements. Aim: This study aimed to develop a real-time tracking system to enable localization of a DRS probe to aid the classification of tumor and non-tumor ...
Jonasson, Hanna Anderson, Chris D. Saager, Rolf B.
Published in
Journal of Biomedical Optics
Significance: Tissue simulating phantoms are an important part of validating biomedical optical techniques. Tissue pathology in inflammation and oedema involves changes in both water and hemoglobin fractions. Aim: We present a method to create solid gelatin-based phantoms mimicking inflammation and oedema with adjustable water and hemoglobin fracti...
Li, Celina L. Fisher, Carl J. Wilson, Brian C. Weersink, Robert A.
Published in
Journal of Biomedical Optics
Significance: Our work demonstrates in preclinical models that continuous-wave transrectal diffuse optical tomography (TRDOT) can be used to accurately monitor photothermal therapy (PTT) and, in particular, the progression of the photocoagulation boundary toward the rectum. When used in patients, this should prevent rectal damage during PTT, thereb...
Sowers, Timothy VanderLaan, Don Karpiouk, Andrei Onohara, Daisuke Schmarkey, Susan Rousselle, Serge Padala, Muralidhar Emelianov, Stanislav
Published in
Journal of Biomedical Optics
Significance: Intravascular photoacoustic (IVPA) imaging can identify native lipid in atherosclerotic plaques in vivo . However, the large number of laser pulses required to produce 3D images is a safety concern that has not been fully addressed. Aim: We aim to evaluate if irradiation at wavelengths and dosages relevant to IVPA imaging causes targe...
Salazar Coariti, Adriana C. Fabien, Maurice S. Guzman, Johnny McGuire, Jeffrey A. De Vita, Raffaella Toussaint, Kimani C. Jr.
Published in
Journal of Biomedical Optics
Significance: The spatial organization of collagen fibers has been used as a biomarker for assessing injury and disease progression. However, quantifying this organization for complex structures is challenging. Aim: To quantify and classify complex collagen fiber organizations. Approach: Using quantitative second-harmonic generation (SHG) microscop...
Zhang, Ke Lu, Xianglan Chen, Xuxin Zhang, Roy Fung, Kar-Ming Liu, Hong Zheng, Bin Li, Shibo Qiu, Yuchen
Published in
Journal of Biomedical Optics
Significance: Searching analyzable metaphase chromosomes is a critical step for the diagnosis and treatment of leukemia patients, and the searching efficiency is limited by the difficulty that the conventional microscopic systems have in simultaneously achieving high resolution and a large field of view (FOV). However, this challenge can be address...
Sadeghi, Jalal Patrone, Paul N. Kearsley, Anthony J. Cooksey, Gregory A.
Published in
Journal of Biomedical Optics
Significance : Performance improvements in microfluidic systems depend on accurate measurement and fluid control on the micro- and nanoscales. New applications are continuously leading to lower volumetric flow rates. Aim : We focus on improving an optofluidic system for measuring and calibrating microflows to the sub-nanoliter per minute range. App...
Green, Stephen Karunakaran, Keerthana Deepti Labadie, Robert Kussman, Barry Mizrahi-Arnaud, Arielle Morad, Andrea Gomez Berry, Delany Zurakowski, David Micheli, Lyle Peng, Ke
...
Published in
Neurophotonics
Significance : Functional near-infrared spectroscopy (fNIRS) has evaluated pain in awake and anesthetized states. Aim : We evaluated fNIRS signals under general anesthesia in patients undergoing knee surgery for anterior cruciate ligament repair. Approach : Patients were split into groups: those with regional nerve block (NB) and those without (non...
