Miracca, Giulia Anuncibay-Soto, Berta Tossell, Kyoko Yustos, Raquel Vyssotski, Alexei L Franks, Nicholas P Wisden, William
Published in
The Journal of neuroscience : the official journal of the Society for Neuroscience
The lateral preoptic (LPO) hypothalamus is a center for NREM and REM sleep induction and NREM sleep homeostasis. Although LPO is needed for NREM sleep, we found that calcium signals were, surprisingly, highest in REM sleep. Furthermore, and equally surprising, NMDA receptors in LPO were the main drivers of excitation. Deleting the NMDA receptor Glu...
Glitz, Leonie Juechems, Keno Summerfield, Christopher Garrett, Neil
Published in
The Journal of Neuroscience
Effective planning involves knowing where different actions take us. However, natural environments are rich and complex, leading to an exponential increase in memory demand as a plan grows in depth. One potential solution is to filter out features of the environment irrelevant to the task at hand. This enables a shared model of transition dynamics ...
Gannon, Mary Wang, Bing Stringfellow, Sara Anne Quintin, Stephan Mendoza, Itzel Srikantha, Thanushri Roberts, A. Claire Saito, Takashi Saido, Takaomi C. Roberson, Erik D.
...
Published in
eNeuro
Alzheimer’s disease (AD) is characterized by progressive cognitive impairment associated with synaptic dysfunction and dendritic spine loss and the pathologic hallmarks of β-amyloid (Aβ) plaques and hyperphosphorylated tau tangles. 14-3-3 proteins are a highly conserved family of proteins whose functions include regulation of protein folding, neuro...
Godenzini, Luca Shai, Adam S. Palmer, Lucy M.
Published in
eNeuro
The dendrites of cortical pyramidal neurons receive synaptic inputs from different pathways that are organized according to their laminar target. This architectural scheme provides cortical neurons with a spatial mechanism to separate information, which may support neural flexibility required during learning. Here, we investigated layer-specific pl...
Acquafredda, Miriam Binda, Paola Lunghi, Claudia
Published in
eNeuro
We used pupillometry to evaluate the effects of attention cueing on perceptual bi-stability, as reported by adult human observers. Perceptual alternations and pupil diameter were measured during two forms of rivalry, generated by presenting a white and a black disk to the two eyes (binocular rivalry) or splitting the disks between eyes (interocular...
Sen, Sriparna Khalsa, Nanak Nihal Tong, Ningcong Ovadia-Caro, Smadar Wang, Xiaoying Bi, Yanchao Striem-Amit, Ella
Published in
The Journal of neuroscience : the official journal of the Society for Neuroscience
Visual cortex organization is highly consistent across individuals. But to what degree does this consistency depend on life experience, in particular sensory experience? In this study, we asked whether visual cortex reorganization in congenital blindness results in connectivity patterns that are particularly variable across individuals, focusing on...
Son, Seoyoung Manjila, Steffy B. Newmaster, Kyra T. Wu, Yuan-ting Vanselow, Daniel J. Ciarletta, Matt Anthony, Todd E. Cheng, Keith C. Kim, Yongsoo
Published in
The Journal of Neuroscience
Oxytocin (Oxt) neurons regulate diverse physiological responses via direct connections with different neural circuits. However, the lack of comprehensive input-output wiring diagrams of Oxt neurons and their quantitative relationship with Oxt receptor (Oxtr) expression presents challenges to understanding circuit-specific Oxt functions. Here, we es...
Rubin, Daniel B Hosman, Tommy Kelemen, Jessica N Kapitonava, Anastasia Willett, Francis R Coughlin, Brian F Halgren, Eric Kimchi, Eyal Y Williams, Ziv M Simeral, John D
...
Published in
The Journal of neuroscience : the official journal of the Society for Neuroscience
Consolidation of memory is believed to involve offline replay of neural activity. While amply demonstrated in rodents, evidence for replay in humans, particularly regarding motor memory, is less compelling. To determine whether replay occurs after motor learning, we sought to record from motor cortex during a novel motor task and subsequent overnig...
Echeverry, Fabio A Ijaz, Sundas Pereda, Alberto E
Published in
eNeuro
The Mauthner cells are a pair of large reticulospinal neurons that organize sensory-evoked tail flip responses in fishes. An identifiable group of auditory "mixed" (electrical and chemical) synaptic contacts known as "Large Myelinated Club endings" on these cells have provided a valuable model for the study of synaptic transmission in the vertebrat...
Holley, S. M. Oikonomou, K. D. Swift, C. M. Mohan, L. Matthews, B. Vega, O. Mkrtchyan, G. Cepeda, C. Levine, M. S.
Published in
eNeuro
As Huntington’s disease (HD) progresses, there is a significant loss of neurons in the striatum in addition to a distinct thinning of the cerebral cortex. Despite an early presence of sensorimotor deficits in patients with HD, electrophysiological studies designed to assess the integrity of thalamocortical circuits are sparse. Using the R6/2 mouse ...
