He, Shenghong Everest-Phillips, Claudia Clouter, Andrew Brown, Peter Tan, Huiling
Published in
The Journal of Neuroscience
Abnormally increased β bursts in cortical-basal ganglia-thalamic circuits are associated with rigidity and bradykinesia in patients with Parkinson's disease. Increased β bursts detected in the motor cortex have also been associated with longer reaction times (RTs) in healthy participants. Here we further hypothesize that suppressing β bursts throug...
Soteropoulos, Demetris S. Baker, Stuart N.
Published in
The Journal of Neuroscience
In an uncertain external environment, the motor system may need to respond rapidly to an unexpected stimulus. Limb displacement causes muscle stretch; the corrective response has multiple activity bursts, which are suggested to originate from different parts of the neuraxis. The earliest response is so fast, it can only be produced by spinal circui...
Boettcher, Sage E.P. Stokes, Mark G. Nobre, Anna C. van Ede, Freek
Published in
The Journal of Neuroscience
Probabilistic associations between stimuli afford memory templates that guide perception through proactive anticipatory mechanisms. A great deal of work has examined the behavioral consequences and human electrophysiological substrates of anticipation following probabilistic memory cues that carry spatial or temporal information to guide perception...
Gill, Jeffrey P. Garcia, Samuel Ting, Lena H. Wu, Mengnan Chiel, Hillel J.
Published in
eNeuro
A software tool for synchronization of video with signals would be of broad general use to behavioral neuroscientists. A new program, called neurotic (NEUROscience Tool for Interactive Characterization), allows users to review and annotate signal data synchronized with video, performs simple initial analyses including signal filtering and spike det...
David, Brian T Curtin, Jessica J Goldberg, David C Scorpio, Kerri Kandaswamy, Veena Hill, Caitlin E
Published in
eNeuro
Cellular transplantation is in clinical testing for a number of central nervous system disorders, including spinal cord injury (SCI). One challenge is acute transplanted cell death. To prevent this death, there is a need to both establish when the death occurs and develop approaches to mitigate its effects. Here, using luciferase (luc) and green fl...
Tikidji-Hamburyan, Ruben A. Canavier, Carmen C.
Published in
eNeuro
All-to-all homogeneous networks of inhibitory neurons synchronize completely under the right conditions; however, many modeling studies have shown that biological levels of heterogeneity disrupt synchrony. Our fundamental scientific question is “how can neurons maintain partial synchrony in the presence of heterogeneity and noise?” A particular sub...
Rogalla, Meike M. Hildebrandt, K. Jannis
Published in
eNeuro
Alterations in inhibitory circuits of the primary auditory cortex (pAC) have been shown to be an aspect of aging and age-related hearing loss (AHL). Several studies reported a decline in parvalbumin (PV) immunoreactivity in aged rodent pAC of animals displaying AHL and conclude a relationship between reduced sensitivity and declined PV immunoreacti...
Zhang, Xiaoyu Yeh, Fang-Chin Ju, Han Jiang, Yuheng Quan, Gabriel Foo Wei VanDongen, Antonius M.J.
Published in
eNeuro
Humans have a large capacity of recognition memory ( Dudai, 1997 ), a fundamental property of higher-order brain functions such as abstraction and generalization ( Vogt and Magnussen, 2007 ). Familiarity is the first step towards recognition memory. We have previously demonstrated using unsupervised neural network simulations that familiarity detec...
Maezono, Sakura Eri B. Kanuka, Mika Tatsuzawa, Chika Morita, Miho Kawano, Taizo Kashiwagi, Mitsuaki Nondhalee, Pimpimon Sakaguchi, Masanori Saito, Takashi Saido, Takaomi C.
...
Published in
eNeuro
Alzheimer’s disease (AD) patients often suffer from sleep disturbances. Alterations in sleep, especially rapid eye movement sleep (REMS), can precede the onset of dementia. To accurately characterize the sleep impairments accompanying AD and their underlying mechanisms using animal models, it is crucial to use models in which brain areas are affect...
Saré, Rachel Michelle Lemons, Abigail Figueroa, Christopher Song, Alex Levine, Merlin Beebe Smith, Carolyn
Published in
eNeuro
Tuberous sclerosis complex (TSC) is an autosomal dominant genetic disorder that is caused by a mutation in either TSC1 or TSC2 . TSC affects multiple systems of the body, and patients with TSC display a range of neurologic and behavioral manifestations including seizures, intellectual disability, autism spectrum disorders, attention deficit hyperac...
