The wisdom of partisan crowds
Published in Proceedings of the National Academy of Sciences
Science and Culture: Painting with invasive pigments
Published in Proceedings of the National Academy of Sciences
Motor origin of temporal predictions in auditory attention
Published in Proceedings of the National Academy of Sciences
Automated glycan assembly using the Glyconeer 2.1 synthesizer.
Published in Proceedings of the National Academy of Sciences of the United States of America
Reliable and rapid access to defined biopolymers by automated DNA and peptide synthesis has fundamentally altered biological research and medical practice. Similarly, the procurement of defined glycans is key to establishing structure-activity relationships and thereby progress in the glycosciences. Here, we describe the rapid assembly of oligosacc...
Real-time analysis of RAG complex activity in V(D)J recombination.
Published in Proceedings of the National Academy of Sciences
Single-molecule FRET (smFRET) and single-molecule colocalization (smCL) assays have allowed us to observe the recombination-activating gene (RAG) complex reaction mechanism in real time. Our smFRET data have revealed distinct bending modes at recombination signal sequence (RSS)-conserved regions before nicking and synapsis. We show that high mobili...
Parent-of-origin effects of A1CF and AGO2 on testicular germ-cell tumors, testicular abnormalities, and fertilization bi...
Published in Proceedings of the National Academy of Sciences
Testicular tumors, the most common cancer in young men, arise from abnormalities in germ cells during fetal development. Unconventional inheritance for testicular germ cell tumor (TGCT) risk both in humans and mice implicates epigenetic mechanisms. Apolipoprotein B mRNA-editing enzyme complex 1 (APOBEC1) cytidine deaminase and Deadend-1, which are ...
Single-molecule visualization of RecQ helicase reveals DNA melting, nucleation, and assembly are required for processive...
Published in Proceedings of the National Academy of Sciences of the United States of America
DNA helicases are motor proteins that unwind double-stranded DNA (dsDNA) to reveal single-stranded DNA (ssDNA) needed for many biological processes. The RecQ helicase is involved in repairing damage caused by DNA breaks and stalled replication forks via homologous recombination. Here, the helicase activity of RecQ was visualized on single molecules...
Hostile attributional bias and aggressive behavior in global context.
...Published in Proceedings of the National Academy of Sciences
We tested a model that children's tendency to attribute hostile intent to others in response to provocation is a key psychological process that statistically accounts for individual differences in reactive aggressive behavior and that this mechanism contributes to global group differences in children's chronic aggressive behavior problems. Particip...
Discovering the first tyrosine kinase.
Published in Proceedings of the National Academy of Sciences of the United States of America
In the middle of the 20th century, animal tumor viruses were heralded as possible models for understanding human cancer. By the mid-1970s, the molecular basis by which tumor viruses transform cells into a malignant state was beginning to emerge as the first viral genomic sequences were reported and the proteins encoded by their transforming genes w...
The spontaneous emergence of conventions: an experimental study of cultural evolution.
Published in Proceedings of the National Academy of Sciences
How do shared conventions emerge in complex decentralized social systems? This question engages fields as diverse as linguistics, sociology, and cognitive science. Previous empirical attempts to solve this puzzle all presuppose that formal or informal institutions, such as incentives for global agreement, coordinated leadership, or aggregated infor...
