Niu, Ran Du, Chrisy Xiyu Esposito, Edward Ng, Jakin Brenner, Michael P. McEuen, Paul L. Cohen, Itai
Published in
Proceedings of the National Academy of Sciences
Programmable self-assembly of smart, digital, and structurally complex materials from simple components at size scales from the macro to the nano remains a long-standing goal of material science. Here, we introduce a platform based on magnetic encoding of information to drive programmable self-assembly that works across length scales. Our building ...
Becker, Joshua Porter, Ethan Centola, Damon
Published in
Proceedings of the National Academy of Sciences of the United States of America
Theories in favor of deliberative democracy are based on the premise that social information processing can improve group beliefs. While research on the "wisdom of crowds" has found that information exchange can increase belief accuracy on noncontroversial factual matters, theories of political polarization imply that groups will become more extrem...
Okabayashi, Norio Peronio, Angelo Paulsson, Magnus Arai, Toyoko Giessibl, Franz J
Published in
Proceedings of the National Academy of Sciences
The oscillation frequencies of a molecule on a surface are determined by the mass distribution in the molecule and the restoring forces that occur when the molecule bends. The restoring force originates from the atomic-scale interaction within the molecule and with the surface, which plays an essential role in the dynamics and reactivity of the mol...
Beans, Carolyn Willow Creek Capital Partners, L.P.
Published in
Proceedings of the National Academy of Sciences
Morillon, Benjamin Baillet, Sylvain
Published in
Proceedings of the National Academy of Sciences
Hahm, Heung Sik Schlegel, Mark K Hurevich, Mattan Eller, Steffen Schuhmacher, Frank Hofmann, Johanna Pagel, Kevin Seeberger, Peter H
Published in
Proceedings of the National Academy of Sciences of the United States of America
Reliable and rapid access to defined biopolymers by automated DNA and peptide synthesis has fundamentally altered biological research and medical practice. Similarly, the procurement of defined glycans is key to establishing structure-activity relationships and thereby progress in the glycosciences. Here, we describe the rapid assembly of oligosacc...
Zagelbaum, Jennifer Shimazaki, Noriko Esguerra, Zitadel Anne Watanabe, Go Lieber, Michael R Rothenberg, Eli
Published in
Proceedings of the National Academy of Sciences
Single-molecule FRET (smFRET) and single-molecule colocalization (smCL) assays have allowed us to observe the recombination-activating gene (RAG) complex reaction mechanism in real time. Our smFRET data have revealed distinct bending modes at recombination signal sequence (RSS)-conserved regions before nicking and synapsis. We show that high mobili...
Carouge, Delphine Blanc, Valerie Knoblaugh, Sue E Hunter, Robert J Davidson, Nicholas O Nadeau, Joseph H
Published in
Proceedings of the National Academy of Sciences
Testicular tumors, the most common cancer in young men, arise from abnormalities in germ cells during fetal development. Unconventional inheritance for testicular germ cell tumor (TGCT) risk both in humans and mice implicates epigenetic mechanisms. Apolipoprotein B mRNA-editing enzyme complex 1 (APOBEC1) cytidine deaminase and Deadend-1, which are ...
Benoit Miotto Ji, Zhe Struhl, Kevin
Published in
Proceedings of the National Academy of Sciences
The origin recognition complex (ORC) binds sites from which DNA replication is initiated. We address ORC binding selectivity in vivo by mapping ∼52,000 ORC2 binding sites throughout the human genome. The ORC binding profile is broader than those of sequence-specific transcription factors, suggesting that ORC is not bound or recruited to specific DN...
Vivar, Omar I. Masi, Giulia Carpier, Jean-Marie Magalhaes, Joao G. Galgano, Donatella Pazour, Gregory J. Amigorena, Sebastian Claire Hivroz Baldari, Cosima T.
Published in
Proceedings of the National Academy of Sciences
Biogenesis of the immune synapse at the interface between antigen-presenting cells and T cells assembles and organizes a large number of membrane proteins required for effective signaling through the T-cell receptor. We showed previously that the intraflagellar transport protein 20 (IFT20), a component of the intraflagellar transport system, contro...
