Takenouchi, Takato Yoshioka, Miyako Yamanaka, Noriko Kitani, Hiroshi
Published in
Cell Biology International Reports
EMT (epithelial-mesenchymal transition) is a key process in the development of liver fibrosis. This process is also essential for liver morphogenesis in embryonic development. To study the cellular and molecular basis of EMT, we established two phenotypically different SV40 large T antigen-immortalized cell lines from rat hepatocytes. The first cel...
The PRH (proline-rich homeodomain) [also known as Hex (haematopoietically expressed homeobox)] protein is a critical regulator of vertebrate development. PRH is able to regulate cell proliferation and differentiation and is required for the formation of the vertebrate body axis, the haematopoietic and vascular systems and the formation of many vita...
Morellet, Nelly Meudal, Hervé Bouaziz, Serge Roques, Bernard Pierre
Published in
Biochemical Journal
The NCps (nucleocapsid proteins) of HIV-1 (HIV type 1), HIV-2 and SIV (simian immunodeficiency virus) are small highly basic proteins, characterized by the presence of two CCHC ZF (zinc finger) domains. NCps, closely associated with the dimeric RNA genome in the core of the virus particle, were shown to promote the specific encapsidation of the vir...
Bourbigot, Sarah Beltz, Hervé Denis, Jérôme Morellet, Nelly Roques, Bernard P Mély, Yves Serge Bouaziz
Published in
Biochemical Journal
HIV-1 Vpr is a highly conserved accessory protein that is involved in many functions of the virus life cycle. Vpr facilitates the entry of the HIV pre-integration complex through the nuclear pore, induces G2 cell cycle arrest, regulates cell apoptosis, increases transcription from the long terminal repeat and enhances viral replication. Vpr contain...
Reeves, Jonathan R Xuan, Jim W Arfanis, Katerina Morin, Catherine Garde, Seema V Ruiz, Marcia T Wisniewski, Jan Panchal, Chandra Tanner, Jerome E
Published in
Biochemical Journal
PSP94 (prostate secretory protein of 94 amino acids), an abundant protein within semen, has reported local functions within the reproductive tract and reported systemic functions. Mechanisms of action remain poorly understood, but binding to undefined molecules within the prostate, pituitary, testis and blood may initiate some of these actions. PSP...
Duguid, R Senior, B
Published in
Biochemical Society Transactions
Tony Hunter
Published in
Biochemical Society Transactions
Folin, O
Published in
Biochemical Journal
Catherine Chailleux Sandrine Tyteca Christophe Papin François Boudsocq Nadine Puget Céline Courilleau Mikhaïl Grigoriev Yvan Canitrot Didier TROUCHE
Published in
Biochemical Journal
Morikis, D Athena Soulika Mallik, B Klepeis, Jl Floudas, Ca Lambris, Jd
Published in
Biochemical Society Transactions
Compstatin is a 13-residue cyclic peptide that has the ability to inhibit the cleavage of C3 to C3a and C3b. The effects of targeting C3 cleavage are threefold, and result in hindrance of: (i) the generation of the pro-inflammatory peptide C3a, (ii) the generation of opsonin C3b (or its fragment C3d), and (iii) further complement activation of the ...
