Takenouchi, Takato Yoshioka, Miyako Yamanaka, Noriko Kitani, Hiroshi
Published in
Cell Biology International Reports
EMT (epithelial-mesenchymal transition) is a key process in the development of liver fibrosis. This process is also essential for liver morphogenesis in embryonic development. To study the cellular and molecular basis of EMT, we established two phenotypically different SV40 large T antigen-immortalized cell lines from rat hepatocytes. The first cel...
The PRH (proline-rich homeodomain) [also known as Hex (haematopoietically expressed homeobox)] protein is a critical regulator of vertebrate development. PRH is able to regulate cell proliferation and differentiation and is required for the formation of the vertebrate body axis, the haematopoietic and vascular systems and the formation of many vita...
Reeves, Jonathan R Xuan, Jim W Arfanis, Katerina Morin, Catherine Garde, Seema V Ruiz, Marcia T Wisniewski, Jan Panchal, Chandra Tanner, Jerome E
Published in
Biochemical Journal
PSP94 (prostate secretory protein of 94 amino acids), an abundant protein within semen, has reported local functions within the reproductive tract and reported systemic functions. Mechanisms of action remain poorly understood, but binding to undefined molecules within the prostate, pituitary, testis and blood may initiate some of these actions. PSP...
Duguid, R Senior, B
Published in
Biochemical Society Transactions
Tony Hunter
Published in
Biochemical Society Transactions
Folin, O
Published in
Biochemical Journal
Catherine Chailleux Sandrine Tyteca Christophe Papin François Boudsocq Nadine Puget Céline Courilleau Mikhaïl Grigoriev Yvan Canitrot Didier TROUCHE
Published in
Biochemical Journal
Morikis, D Athena Soulika Mallik, B Klepeis, Jl Floudas, Ca Lambris, Jd
Published in
Biochemical Society Transactions
Compstatin is a 13-residue cyclic peptide that has the ability to inhibit the cleavage of C3 to C3a and C3b. The effects of targeting C3 cleavage are threefold, and result in hindrance of: (i) the generation of the pro-inflammatory peptide C3a, (ii) the generation of opsonin C3b (or its fragment C3d), and (iii) further complement activation of the ...
Jeremy Sanford Ellis, J Cáceres, Jf
Published in
Biochemical Society Transactions
SR proteins (serine- and arginine-rich proteins) are an evolutionarily conserved family consisting of essential pre-mRNA splicing factors. Since their discovery and initial characterization, roles of SR proteins in pre-mRNA splicing and in subsequent steps of post-transcriptional gene expression have expanded significantly. The current hypotheses s...
Erkki Ruoslahti Engvall, E Hayman, Eg Spiro, Rg
Published in
Biochemical Journal
Human fibronectin was isolated from second-trimester amniotic fluid, from amniotic fluid obtained at term and from adult plasma. The amniotic-fluid fibronectins had a slightly higher apparent molecular weight on sodium dodecyl sulphate/polyacrylamide-gel electrophoresis than the plasma fibronectin. Early- and late-amniotic-fluid fibronectin had 9.5...
