Takenouchi, Takato Yoshioka, Miyako Yamanaka, Noriko Kitani, Hiroshi
Published in
Cell Biology International Reports
EMT (epithelial-mesenchymal transition) is a key process in the development of liver fibrosis. This process is also essential for liver morphogenesis in embryonic development. To study the cellular and molecular basis of EMT, we established two phenotypically different SV40 large T antigen-immortalized cell lines from rat hepatocytes. The first cel...
The PRH (proline-rich homeodomain) [also known as Hex (haematopoietically expressed homeobox)] protein is a critical regulator of vertebrate development. PRH is able to regulate cell proliferation and differentiation and is required for the formation of the vertebrate body axis, the haematopoietic and vascular systems and the formation of many vita...
Reeves, Jonathan R Xuan, Jim W Arfanis, Katerina Morin, Catherine Garde, Seema V Ruiz, Marcia T Wisniewski, Jan Panchal, Chandra Tanner, Jerome E
Published in
Biochemical Journal
PSP94 (prostate secretory protein of 94 amino acids), an abundant protein within semen, has reported local functions within the reproductive tract and reported systemic functions. Mechanisms of action remain poorly understood, but binding to undefined molecules within the prostate, pituitary, testis and blood may initiate some of these actions. PSP...
Duguid, R Senior, B
Published in
Biochemical Society Transactions
Tony Hunter
Published in
Biochemical Society Transactions
Folin, O
Published in
Biochemical Journal
Liew, Cw Huaiyu Sun Tony Hunter Day, Cl
Published in
Biochemical Journal
RNF4 [RING (really interesting new gene) finger protein 4] family ubiquitin ligases are RING E3 ligases that regulate the homoeostasis of SUMOylated proteins by promoting their ubiquitylation. In the present paper we report that the RING domain of RNF4 forms a stable dimer, and that dimerization is required for ubiquitin transfer. Our results sugge...
Jérémie Kropp Cindy Degerny Nadezda Morozova Julien PONTIS Annick Harel-Bellan Anna Polesskaya
Published in
Biochemical Journal
Catherine Chailleux Sandrine Tyteca Christophe Papin François Boudsocq Nadine Puget Céline Courilleau Mikhaïl Grigoriev Yvan Canitrot Didier TROUCHE
Published in
Biochemical Journal
Morikis, D Athena Soulika Mallik, B Klepeis, Jl Floudas, Ca Lambris, Jd
Published in
Biochemical Society Transactions
Compstatin is a 13-residue cyclic peptide that has the ability to inhibit the cleavage of C3 to C3a and C3b. The effects of targeting C3 cleavage are threefold, and result in hindrance of: (i) the generation of the pro-inflammatory peptide C3a, (ii) the generation of opsonin C3b (or its fragment C3d), and (iii) further complement activation of the ...
