Seidel, Monika de Meritens, Camille Rabesahala Johnson, Louisa Parthimos, Dimitris Bannister, Mark Thomas, Nia Lowri Ozekhome-Mike, Esizaze Lai, Francis Anthony Zissimopoulos, Spyros
Published in
Cardiovascular research
The cardiac ryanodine receptor (RyR2), which mediates intracellular Ca2+ release to trigger cardiomyocyte contraction, participates in development of acquired and inherited arrhythmogenic cardiac disease. This study was undertaken to characterize the network of inter- and intra-subunit interactions regulating the activity of the RyR2 homotetramer. ...
Lee, Yee-Ki Sala, Luca Mura, Manuela Rocchetti, Marcella Pedrazzini, Matteo Ran, Xinru Mak, Timothy S H Crotti, Lia Sham, Pak C Torre, Eleonora
...
Published in
Cardiovascular research
In long QT syndrome (LQTS) patients, modifier genes modulate the arrhythmic risk associated with a disease-causing mutation. Their recognition can improve risk stratification and clinical management, but their discovery represents a challenge. We tested whether a cellular-driven approach could help to identify new modifier genes and especially thei...
Burger, Fabienne Miteva, Kapka Baptista, Daniela Roth, Aline Fraga-Silva, Rodrigo A Martel, Catherine Stergiopulos, Nikolaos Mach, François Brandt, Karim J
Published in
Cardiovascular research
B cell functions in the process of atherogenesis have been investigated but several aspects remain to be clarified. In this study, we show that follicular regulatory helper T cells (TFR) control regulatory B cell (BREG) populations in Apoe-/- mice models on a high-cholesterol diet (HCD). Feeding mice with HCD resulted in up-regulation of TFR and BR...
Hamaoka, Michinori Nakagawa, Masataka Nakahara, Hideki Yamamoto, Rie Nishisaka, Takashi Itamoto, Toshiyuki
Published in
Journal of Surgical Case Reports
Malignant pleural mesothelioma (MPM) is an aggressive form of malignant tumor that originates in the pleural mesothelioma and presents as a local disease in the affected hemithorax. Small intestine metastasis is a rare complication. Herein, the case of a patient with jejunal intussusception caused by small intestine metastasis of MPM has been repor...
Filgueiras-Rama, David Vasilijevic, Jasmina Jalife, Jose Noujaim, Sami F Alfonso, Jose M Nicolas-Avila, Jose A Gutierrez, Celia Zamarreño, Noelia Hidalgo, Andres Bernabé, Alejandro
...
Published in
Cardiovascular research
Human influenza A virus (hIAV) infection is associated with important cardiovascular complications, although cardiac infection pathophysiology is poorly understood. We aimed to study the ability of hIAV of different pathogenicity to infect the mouse heart, and establish the relationship between the infective capacity and the associated in vivo, cel...
Bartoli-Leonard, Francesca Wilkinson, Fiona L Schiro, Andrew Serracino Inglott, Ferdinand Alexander, M Yvonne Weston, Ria
Published in
Cardiovascular research
Vascular calcification is a recognized predictor of cardiovascular risk in the diabetic patient, with DNA damage and accelerated senescence linked to oxidative stress-associated pathological calcification. Having previously shown that systemic SIRT1 is reduced in diabetes, the aim was to establish whether SIRT1 is protective against a DNA damage-in...
Samet, Jonathan M
Published in
JNCI Cancer Spectrum
Coleman, Nathan C Ezzati, Majid Marshall, Julian D Robinson, Allen L Burnett, Richard T Pope, C Arden III
Published in
JNCI Cancer Spectrum
Background Exposure to fine particulate matter (PM2.5) air pollution has been linked to increased risk of mortality, especially cardiopulmonary and lung cancer mortality. It is unknown if cancer patients and survivors are especially vulnerable to PM2.5 air pollution exposure. This study evaluates PM2.5 exposure and risk for cancer and cardiopulmona...
Essig, Marie Matt, Morgan Massy, Ziad
Published in
Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association
Connor, Katie L Denby, Laura
Published in
Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association
