Teaching neuroImages: double cortex: "two" is too many.
Published in Neurology
Determinants of survival in progressive multifocal leukoencephalopathy.
...Published in Neurology
The presence of JC virus (JCV)-specific cytotoxic T-lymphocytes (CTL) was associated with a trend toward longer survival in patients with progressive multifocal leukoencephalopathy (PML), which was more pronounced than the impact of CD4 count in HIV+ patients with PML early after diagnosis. Despite the association of contrast enhancement and immune...
Absence of ubiquitinated inclusions in hypocretin neurons of patients with narcolepsy
Published in Neurology
Objectives: The cause of hypocretin cell loss in human narcolepsy–cataplexy is unknown but has been suggested to be neurodegenerative in nature. To test this hypothesis, we evaluated the remaining hypocretin cells in human narcolepsy brains for the presence of aggregated protein inclusions, gliosis, and inflammation. Methods: Brains were examined b...
Bevacizumab and chemotherapy for recurrent glioblastoma: a single-institution experience.
...Published in Neurology
Imaging of Bing-Neel syndrome.
Published in Neurology
Bevacizumab for recurrent malignant gliomas: efficacy, toxicity, and patterns of recurrence.
...Published in Neurology
Combination therapy with bevacizumab and chemotherapy is well-tolerated and active against recurrent malignant gliomas. At recurrence, continuing bevacizumab and changing the chemotherapy agent provided long-term disease control only in a small subset of patients. Bevacizumab may alter the recurrence pattern of malignant gliomas by suppressing enha...
The evolution of neutralizing antibodies in multiple sclerosis patients treated with interferon beta-1b.
Published in Neurology
The fate of the neutralizing antibody (NAB) in MS patients treated with interferons remains unclear. We conducted a follow-up survey of NAB titers in 59 long-term treated patients from the London and Vancouver cohorts of the pivotal trial of interferon alpha-1b. NAB were measured with the myxovirus protein A assay and an ELISA, at a mean follow-up ...
Hereditary endotheliopathy with retinopathy, nephropathy, and stroke (HERNS)
Published in Neurology
SPP1 genotype is a determinant of disease severity in Duchenne muscular dystrophy: predicting the severity of Duchenne m...
Published in Neurology
Familial migraine with vertigo and essential tremor.
Published in Neurology
We report a family with dominantly inherited migraine headaches, episodic vertigo, and essential tremor. All symptoms improved with the use of acetazolamide. Linkage analysis ruled out linkage to markers on chromosome 19p, known to be linked to the genetic defect in families with the clinically similar syndromes of hemiplegic migraine and periodic ...
