Pesce, Bárbara Ribeiro, Carolina H Larrondo, Milton Ramos, Verónica Soto, Lilian Catalán, Diego Aguillón, Juan Carlos
Published in
International journal of molecular sciences
Tumor necrosis factor (TNF)-α is a pleiotropic cytokine implicated in the etiology of several autoimmune diseases, including rheumatoid arthritis (RA). TNF-α regulates diverse effector functions through the activation of TNF-α receptor (TNFR)1 and TNFR2. Although the detrimental role of this cytokine has been addressed in distinct disease settings,...
Quintás, Guillermo Caiment, Florian Rienda, Iván Pérez-Rojas, Judith Pareja, Eugenia Castell, José V Jover, Ramiro
Published in
International journal of molecular sciences
Non-alcoholic fatty liver disease (NAFLD) is the most prevalent form of chronic liver disease worldwide, but a reliable non-invasive method to quantify liver steatosis in primary healthcare is not available. Circulating microRNAs have been proposed as biomarkers of severe/advanced NAFLD (steatohepatitis and fibrosis). However, the use of circulatin...
Rojas-García, Alejandro Rodríguez, Lyanne Cádiz-Gurrea, María de la Luz García-Villegas, Abigail Fuentes, Eduardo Villegas-Aguilar, María Del Carmen Palomo, Iván Arráez-Román, David Segura-Carretero, Antonio
Published in
International journal of molecular sciences
Annona cherimola fruit, known as cherimoya or custard apple, is an exotic fruit from South America but is strongly produced in Andalusia, Spain. Its by-products (seeds and peel) are recognised as important sources of antioxidants, including phenolic acids, flavonoids and procyanidins. Therefore, the aim of this study was to carry out the characteri...
Schellens, Sam Lenaerts, Cynthia Pérez Baca, María Del Rocío Cools, Dorien Peeters, Paulien Marchal, Elisabeth Vanden Broeck, Jozef
Published in
International journal of molecular sciences
Ecdysteroids are widely investigated for their role during the molting cascade in insects; however, they are also involved in the development of the female reproductive system. Ecdysteroids are synthesized from cholesterol, which is further converted via a series of enzymatic steps into the main molting hormone, 20-hydoxyecdysone. Most of these bio...
Bocos-Asenjo, Irene Teresa Niño-Sánchez, Jonatan Ginésy, Mireille Diez, Julio Javier
Published in
International journal of molecular sciences
RNA-based strategies for plant disease management offer an attractive alternative to agrochemicals that negatively impact human and ecosystem health and lead to pathogen resistance. There has been recent interest in using mycoviruses for fungal disease control after it was discovered that some cause hypovirulence in fungal pathogens, which refers t...
Liu, Yang Yamagishi, Reiko Honjo, Megumi Kurano, Makoto Yatomi, Yutaka Igarashi, Koji Aihara, Makoto
Published in
International journal of molecular sciences
Autotaxin (ATX) is an enzymatic with lysophospholipase D (lysoPLD) activity. We investigated the role of ATX in high glucose (HG)-induced human retinal pigment epithelial (ARPE-19) cells to explore the pathogenesis of diabetic retinopathy (DR). We performed a quantitative real-time polymerase chain reaction, Western blotting, immunocytochemistry, e...
Almeida, Bruno Rafael Ribeiro de Noronha, Renata Coelho Rodrigues Cardoso, Adauto Lima Martins, Cesar Martins, Jonas Gama Procópio, Rudi Emerson de Lima Nagamachi, Cleusa Yoshiko Pieczarka, Julio Cesar
Published in
International journal of molecular sciences
Several species of Tityus (Scorpiones, Buthidae) present multi-chromosomal meiotic associations and failures in the synaptic process, originated from reciprocal translocations. Holocentric chromosomes and achiasmatic meiosis in males are present in all members of this genus. In the present study, we investigated synapse dynamics, transcriptional si...
Urusov, Andrey E Aulova, Kseniya S Dmitrenok, Pavel S Buneva, Valentina N Nevinsky, Georgy A
Published in
International journal of molecular sciences
Histones play vital roles in chromatin functioning and gene transcription, but in intercellular space, they are harmful due to stimulating systemic inflammatory and toxic responses. Myelin basic protein (MBP) is the most important protein of the axon myelin-proteolipid sheath. Antibodies-abzymes with different catalytic activities are critical and ...
Kmiecik, Alicja Ratajczak-Wielgomas, Katarzyna Grzegrzółka, Jędrzej Romanowicz, Hanna Smolarz, Beata Dziegiel, Piotr
Published in
International journal of molecular sciences
Recently, the expression of NUCB2/NESF-1 has been linked to tumor development. We report NUCB2/NESF-1 expression and its relation to clinicopathological parameters in breast cancer cells. Immunohistochemical reactions were conducted on 446 cases of invasive ductal carcinoma (IDC) and 36 cases of mastopathy. The expression of NUCB2/NESF-1 was also e...
Pulford, Christopher S Uppalapati, Chandana K Montgomery, McKale R Averitte, Richard L Hull, Elizabeth E Leyva, Kathryn J
Published in
International journal of molecular sciences
While most cases of cutaneous squamous cell carcinoma (cSCC) are benign, invasive cSCC is associated with higher mortality and is often more difficult to treat. As such, understanding the factors that influence the progression of cSCC are important. Aggressive cancers metastasize through a series of evolutionary changes, collectively called the epi...
