Calcium phosphates (CaP) represent an important class of osteoconductive and osteoinductive biomaterials. As proof-of-concept, we show how a multi-component CaP formulation (monetite, beta-tricalcium phosphate, and calcium pyrophosphate) guides osteogenesis beyond the physiological envelope. In a sheep model, hollow dome-shaped constructs were plac...
Published in Bioactive materials
Regenerative bone implants promote new bone formation and ideally degrade simultaneously to osteogenesis. Although clinically established calcium phosphate bone grafts provide excellent osseointegration and osteoconductive efficacy, they are limited in terms of bioresorption. Magnesium phosphate (MP) based ceramics are a promising alternative, beca...
Published in Bioactive Materials
• BEZ-235 + Gel promotes the maturation of sarcomere structure in iPSC-CMs. • BEZ-235 + Gel promotes electrophysiological maturation of iPSC-CMs. • BEZ-235 + Gel increases mitochondrial respiration in iPSC-CMs. • Gel loaded with mature iPSC-CMs enhanced angiogenesis and gap junction formation at the injection site.
Published in Bioactive Materials
• Tensile strength and elongation of Zn alloys can reach over 220 MPa and 30%, respectively. • Three in vivo implantation models to investigate and compare biodegradations behavior at different locations of the body. • Zn–Zr and Zn–V alloys can induce pro-regenerative inflammation responses in aortas. • All Zn alloys can promote osteointegration in...
Published in Bioactive Materials
• Rapid development of gatifloxacin-loaded IOL by photocuring with the aid of 3D-printed molds. • A satisfying drug release profile driven by monomer formula programming. • Gatifloxacin-loaded IOL exhibited remarkable prevention of endophthalmitis in vivo. • Drug-eluting IOL with outstanding optical and mechanical properties.
Published in Bioactive Materials
• Oxygen microcapsules could efficiently reverse the hypoxic condition both in vitro and in vivo without any damage to major organs • Oxygen microcapsules could significantly improve the efficacy of anti-PD-1 antibody against PDAC by anti-tumor immune response in TME. • Reversing hypoxia in TME by using oxygen microcapsules holds great potential fo...
Published in Infectious Disease Modelling
Several epidemiological models have been proposed to study the evolution of COVID-19 pandemic. In this paper, we propose an extension of the SUIHTER model, to analyse the COVID-19 spreading in Italy, which accounts for the vaccination campaign and the presence of new variants when they become dominant. In particular, the specific features of the va...
Published in Infectious Disease Modelling
Serological surveys were used to infer the infection attack rate in different populations. The sensitivity of the testing assay, Abbott, drops fast over time since infection which makes the serological data difficult to interpret. In this work, we aim to solve this issue. We collect longitudinal serological data of Abbott to construct a sensitive d...
Published in Bioactive Materials
• A multifunctional silk-based hydrogel incorporated with metal-organic framework nanozymes ([email protected]) was fabricated. • [email protected] hydrogel has antioxidant, anti-inflammation and antibacterial capacities. • Proteomics analysis confirmed that [email protected] hydrogel promoted cell proliferation and ECM synthesis. • [email protected] hydrogel displayed successful osteoch...
Published in Bioactive Materials
• The poor homing and retention capacity greatly limited the possible clinical application of sEVs derived from MSCs. • CREKA modification enabled sEVs to bind fibrin effectively and promoted their accumulation and retention in bone defects. • CREKA-sEVs enhanced bone repair substantially in the rat femoral defect model.
