Zhang, Zhaowenbin Li, Wenbo Liu, Ying Yang, Zhigang Ma, Lingling Zhuang, Hui Wang, Endian Wu, Chengtie Huan, Zhiguang Guo, Feng
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Bioactive materials
The deep burn skin injures usually severely damage the dermis with the loss of hair follicle loss, which are difficult to regenerate. Furthermore, severe burns often accompanied with large amount of wound exudates making the wound moist, easily infected, and difficult to heal. Therefore, it is of great clinical significance to develop wound dressin...
Zheng, Maochao Pan, Miao Zhang, Wancong Lin, Huanchang Wu, Shenlang Lu, Chao Tang, Shijie Liu, Daojun Cai, Jianfeng
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Bioactive materials
Poly(α-l-lysine) (PLL) is a class of water-soluble, cationic biopolymer composed of α-l-lysine structural units. The previous decade witnessed tremendous progress in the synthesis and biomedical applications of PLL and its composites. PLL-based polymers and copolymers, till date, have been extensively explored in the contexts such as antibacterial ...
Adriano, Benilde Cotto, Nycol M. Chauhan, Neeraj Jaggi, Meena Chauhan, Subhash C. Yallapu, Murali M.
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Bioactive Materials
• Milk exosomes are nature's abundant drug delivery carriers. • These exosomes exhibit superior stability, biocompatibility, half-life, and very low immunogenicity. • This work describes isolation methods, drug/imaging agents loading, and therapeutic implications of milk exosomes. • Engineered milk exosomes offer superior theranostic applications.
Shuai, Cijun Yang, Wenjing Feng, Pei Peng, Shuping Pan, Hao
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Bioactive materials
The incorporation of hydroxyapatite (HAP) into poly-l-lactic acid (PLLA) matrix serving as bone scaffold is expected to exhibit bioactivity and osteoconductivity to those of the living bone. While too low degradation rate of HAP/PLLA scaffold hinders the activity because the embedded HAP in the PLLA matrix is difficult to contact and exchange ions ...
Chen, Lu Cheng, Liying Wang, Zhen Zhang, Jianming Mao, Xiyuan Liu, Zhimo Zhang, Yuguang Cui, Wenguo Sun, Xiaoming
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Bioactive materials
Conditioned medium (CM) contains variety of factors secreted by cells, which directly regulate cellular processes, showing tremendous potential in regenerative medicine. Here, for the first time, we proposed a novel regenerative therapy mediated by biodegradable micro-nano electrospun fibers loaded with highly active conditioned medium of adipose-d...
Zhang, Yushan Elechalawar, Chandra Kumar Hossen, Md Nazir Francek, Emmy R Dey, Anindya Wilhelm, Stefan Bhattacharya, Resham Mukherjee, Priyabrata
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Bioactive materials
Cancer-associated fibroblasts (CAFs) are a major constituent of the tumor microenvironment (TME) and an important contributor to cancer progression and therapeutic resistance. Regulation of CAF activation is a promising strategy to influence cancer outcomes. Here, we report that ovarian cancer cells (OCs) and TME cells promote the activation of ova...
Liang, Ye Wang, Yonghua Wang, Liping Liang, Zhijuan Li, Dan Xu, Xiaoyu Chen, Yuanbin Yang, Xuecheng Zhang, Hongbo Niu, Haitao
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Bioactive materials
Bladder cancer is one of the concerning malignancies worldwide, which is lacking effective targeted therapy. Gene therapy is a potential approach for bladder cancer treatment. While, a safe and effective targeted gene delivery system is urgently needed for prompting the bladder cancer treatment in vivo. In this study, we confirmed that the bladder ...
Zhang, Xiaoge Tang, Junjie Li, Chao Lu, Yao Cheng, Lili Liu, Jie
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Bioactive materials
Photo-immunotherapy is a novel therapeutic approach against malignant tumors with minimal invasiveness. Herein, a targeting multifunctional black phosphorus (BP) nanoparticle, modified by PEGylated hyaluronic acid (HA), was designed for photothermal/photodynamic/photo-immunotherapy. In vitro and in vivo assays indicated that HA-BP nanoparticles pos...
Liu, Li Huang, Bo Liu, Xiangmei Yuan, Wei Zheng, Yufeng Li, Zhaoyang Yeung, Kelvin Wai Kwok Zhu, Shengli Liang, Yanqin Cui, Zhenduo
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Bioactive materials
A PLGA/Ti3C2 hybrid coating was successfully deposited on the surface of magnesium-strontium (Mg-Sr) alloys. Compared with the corrosion current density (i corr ) of the Mg-Sr alloy (7.13 × 10-5 A/cm2), the modified samples (Mg/PLGA/Ti3C2) was lower by approximately four orders of magnitude (7.65 × 10-9 A/cm2). After near infrared 808 nm laser irra...
Fan, Zhijin Liu, Hongxing Xue, Yaohua Lin, Jingyan Fu, Yu Xia, Zhaohua Pan, Dongming Zhang, Jian Qiao, Kun Zhang, Zhenzhen
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Bioactive materials
Immunotherapy assays using immunoadjuvants and tumor antigens could greatly increase the survival rates of patients with malignant tumors. As effective carriers, metal-organic frameworks (MOFs) have been widely utilized in cancer therapy due to their remarkable histocompatibility and low toxicity. Herein, we constructed a multimodal imaging-guided ...
