PASVENSKAITE, AGNE LIUTKEVICIENE, RASA GEDVILAITE, GRETA VILKEVICIUTE, ALVITA LIUTKEVICIUS, VYKINTAS ULOZA, VIRGILIJUS
Published in
Cancer Genomics & Proteomics
Background/Aim: Prognosis of advanced stages of laryngeal squamous cell carcinoma (LSCC) remains poor. To clarify therapeutic targets and improve survival rate, identification of new specific and prognostic biomarkers of LSCC is required. The study aimed to evaluate the impact of IL-10:rs1800871, rs1800872, rs1800896 single nucleotide polymorphisms...
PROMMAJUN, PATTAMA PHETCHARABURANIN, JUTAROP NAMWAT, NISANA KLANRIT, PORAMATE SA-NGIAMWIBOOL, PRAKASIT THANEE, MALINEE DOKDUANG, HASAYA KITTIRAT, YINGPINYAPAT LI, JIA V. LOILOME, WATCHARIN
...
Published in
Cancer Genomics & Proteomics
Background: Opisthorchis viverrini (Ov) infection-induced cholangiocarcinoma (CCA) is a major public health problem in northeastern Thailand. Praziquantel was shown to prevent CCA development in an Ov-infected hamster model; however, the molecular mechanism remains unknown. Materials and Methods: In this study, we used a hamster model with Ov and N...
CHANG, JOHN WEN-CHENG HSIEH, JIA-JUAN WU, CHIAO-EN LIM, ABNER HERBERT NG, CEDRIC CHUAN-YOUNG TEH, BIN TEAN CHAN, JASON YONGSHENG
Published in
Cancer Genomics & Proteomics
Background/Aim: Acral melanomas (AM) represent a rare subgroup of melanomas with poor clinical outcomes and are enriched in Asian populations. Recent advances in next generation sequencing have provided opportunities to apply precision medicine to AM. Patients and Methods: Here, we present a series of 13 patients with melanomas from Taiwan and Sing...
IDETA, YUKA TAGAWA, TAKANOBU HAYASHI, YUICHIRO BABA, JUNICHI TAKAHASHI, KIMIKO MITSUDO, KENJI SAKURAI, KOUHEI
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Cancer Genomics & Proteomics
Background/Aim: Metastasis to cervical lymph nodes of oral squamous cell carcinoma (OSCC) leads to a poor prognosis. The present study aimed at investigating the pathways and molecules associated with OSCC metastasis. Materials and Methods: The transcriptome between HSC-3 cells and their highly metastatic subline, HSC-3-M3 cells, was examined using...
WEIDLE, ULRICH H. BIRZELE, FABIAN NOPORA, ADAM
Published in
Cancer Genomics & Proteomics
The annual death toll for gastric cancer is in the range of 700,000 worldwide. Even in patients with early-stage gastric cancer recurrence within five years has been observed after surgical resection and following chemotherapy with therapy-resistant features. Therefore, the identification of new targets and treatment modalities for gastric cancer i...
WANG, ANYOU HAI, RONG
Published in
Cancer Genomics & Proteomics
Numerous cancer drivers have been identified, but they are specific to a given cancer type and condition; universal cancer drivers and universal cancer mechanisms still remain largely unclear. Here, we identified the deadliest universal drivers for all cancers via developing algorithms to analyze massive RNAseqs and clinical data from The Cancer Ge...
PANAGOPOULOS, IOANNIS ANDERSEN, KRISTIN EILERT-OLSEN, MARTINE ZELLER, BERNWARD MUNTHE-KAAS, MONICA CHENG BUECHNER, JOCHEN OSNES, LIV T.N. MICCI, FRANCESCA HEIM, SVERRE
Published in
Cancer Genomics & Proteomics
Background/Aim: Fusion of histone-lysine N-methyltransferase 2A gene (KMT2A) with the Rho guanine nucleotide exchange factor 12 gene (ARHGEF12), both located in 11q23, was reported in some leukemic patients. We report a KMT2A-ARHGEF12 fusion occurring during treatment of a pediatric acute myeloid leukemia (AML) with topoisomerase II inhibitors lead...
YEO, MIN-KYUNG BAE, GO EUN
Published in
Cancer Genomics & Proteomics
Background: Malignant pilomatricoma (MP) is a rare cancer of the hair matrix with only a few cases reported in literature. Given the rarity of this cancer and the lack of relevant genetic data, very little is known about the nature of the molecular pathophysiology except the involvement of the Catenin Beta 1 (CTNNB1)/Wnt/β-catenin signaling pathway...
KOROVESI, ARTEMIS G. ANAGNOSTOPOULOS, ATHANASIOS K. PIERROS, VASILEIOS STRAVOPODIS, DIMITRIOS J. TSANGARIS, GEORGE TH.
Published in
Cancer Genomics & Proteomics
Background/Aim: Proteomics technologies provide fundamental insights into the high organizational complexity and diversity of the central nervous system. In the present study, high-resolution mass spectrometry (MS) was applied in order to identify whole-proteome content of anatomically distinct and functionally specific mouse brain regions. Materia...
WITTELER, JASPAR SCHILD, STEVEN E. RADES, DIRK
Published in
In Vivo
Background/Aim: Personalized treatment for low-grade gliomas likely improves patient outcomes. This study aimed to identify predictors of local control and survival. Patients and Methods: Twenty-five patients irradiated for grade II gliomas were retrospectively analyzed. Irradiation was performed after biopsy (n=6) or incomplete resection (n=19). N...
