Hichri, F. Omri, A. Hossan, ASM Ben Jannet, H.
Published in
Pharmaceutical Biology
Context: The substantial increase in the number of diabetics has encouraged the search for new pharmacological strategies to face this problem. In this regard, triazole and its derivatives have attracted considerable attention for the past few decades due to their pharmacological significance. Objective: Evaluation of the inhibitory activity of α-g...
Sadun, Rebecca E Chung, Richard J Pollock, Mclean D Maslow, Gary R
Published in
Medical education online
The transition from pediatric to adult healthcare is a vulnerable time for adolescents and young adults (AYA), especially those with chronic conditions. Successful transition requires communication and coordination amongst providers, patients, and families. Unfortunately, multiple studies have demonstrated that the majority of practicing providers ...
Sharabi, Shirley Bresler, Yael Ravid, Orly Shemesh, Chen Atrakchi, Dana Schnaider-Beeri, Michal Gosselet, Fabien Dehouck, Lucie Last, David Guez, David
...
Published in
Drug delivery
The blood-brain barrier (BBB) is limiting transcellular and paracellular movement of molecules and cells, controls molecular traffic, and keeps out toxins. However, this protective function is the major hurdle for treating brain diseases such as brain tumors, Parkinson's disease, Alzheimer's disease, etc. It was previously demonstrated that high pu...
Maervoet, J. Bossers, N. Borge, R. P. Hilpert, S. Thompson van Engen, A. Smala, A.
Published in
Journal of Medical Economics
Objectives: Atrial fibrillation (AF) is the most common arrhythmia and a major marker of ischemic stroke risk. Early detection is crucial and, once diagnosed, anticoagulation therapy can be initiated to reduce stroke risk. The aim of this study was to assess the cost-effectiveness of employing an insertable cardiac monitor (ICM), BIOMONITOR, for th...
Liu, Lina Zhang, Haoran Mao, Hongyu Li, Xiaohong Hu, Yamin
Published in
Artificial Cells, Nanomedicine, and Biotechnology
MicroRNAs (miRNAs) play a key role in various pathological processes like atrial fibrillation (AF), which is a common cardiac arrhythmia. Exosomes are essential information carrier in the intercellular communication. Therefore, this study aimed to investigate the effects of exosomal miR-320d on cardiomyocytes with AF and related mechanisms. To do t...
Nakajima, Tadashi Kaneko, Yoshiaki Dharmawan, Tommy Kurabayashi, Masahiko
Published in
Channels
The segment 4 (S4) voltage sensor in voltage-gated sodium channels (Navs) have domain-specific functions, and the S4 segment in domain DIV (DIVS4) plays a key role in the activation and fast inactivation processes through the coupling of arginine residues in DIVS4 with residues of putative gating charge transfer center (pGCTC) in DIVS1-3. In additi...
Menden, Ariane Hall, Davane Paris, Daniel Mathura, Venkatarian Crawford, Fiona Mullan, Michael Crynen, Stefan Ait-Ghezala, Ghania
Published in
Journal of Enzyme Inhibition and Medicinal Chemistry
The discovery of allosteric modulators is a multi-disciplinary approach, which is time- and cost-intensive. High-throughput screening combined with novel computational tools can reduce these factors. Thus, we developed an enzyme activity assay, which can be included in the drug discovery work-flow subsequent to the in-silico library screening. Whil...
Nam, Yunju Hwang, Dongkeun Kim, Namdoo Seo, Hong-Seog B. Selim, Khalid Sim, Taebo
Published in
Journal of Enzyme Inhibition and Medicinal Chemistry
Anaplastic lymphoma kinase (ALK) has been recognised as a promising molecular target of targeted therapy for NSCLC. We performed SAR study of pyrazolo[3,4-b]pyridines to override crizotinib resistance caused by ALK-L1196M mutation and identified a novel and potent L1196M inhibitor, 10g. 10g displayed exceptional enzymatic activities (
Yang, H Liu, Z Song, Y Hu, C
Published in
Drug Delivery
Arthritis treatment has been challenging because of low drug exposure to the articular cavity. This study was intended to develop hyaluronic acid (HA)-functionalized bilosomes for targeted delivery of tripterine (Tri), an antiphlogistic phytomedicine, to the inflamed joint via ligand-receptor interaction. Tri-loaded bilosomes (Tri-BLs) with cationi...
Teixeira, BVF Teles, ALB Silva, SGD Brito, CCB Freitas, HF Pires, ABL Froes, TQ Castilho, MS
Published in
Journal of Enzyme Inhibition and Medicinal Chemistry
Leishmaniasis is a tropical disease found in more than 90 countries. The drugs available to treat this disease have nonspecific action and high toxicity. In order to develop novel therapeutic alternatives to fight this ailment, pteridine reductase 1 (PTR1) and dihydrofolate reductase-thymidylate synthase (DHF-TS) have been targeted, once Leishmania...
