McDonnell, Leah Lavoie, Josée G Healy, Gwen Wong, Sabrina Goulet, Sara Clark, Wayne
Published in
International journal of circumpolar health
A medevac involves the transport of a critically ill patient, usually by plane or helicopter, to access necessary and at times life-saving care, most often only accessible in urban centres. Medevacs are commonly used in resource-limited and geographically isolated areas in Canada. The objective of this study was to explore the determinants of medev...
Stoor, Jon Petter Anders Berntsen, Gro Hjelmeland, Heidi Silviken, Anne
Published in
International journal of circumpolar health
Suicide is a major public health issue across the Arctic, especially among Indigenous Peoples. The aim of this study was to explore and describe cultural meanings of suicide among Sámi in Norway. Five open-ended focus group discussions (FGDs) were conducted with 22 Sámi (20) and non-Sámi (2) participants in South, Lule, Marka, coastal and North Sám...
Ellis, Michael J Boles, Susan Derksen, Vickie Dawyduk, Brenda Amadu, Adam Stelmack, Karen Kowalchuk, Matthew Russell, Kelly
Published in
International journal of circumpolar health
Pediatric concussion patients living in northern communities in Canada can face unique challenges accessing primary and specialized healthcare. In this study we report the clinical characteristics, healthcare utilization, outcomes and estimated cost avoidance associated with a pilot pediatric concussion telemedicine program established between a mu...
De Simone, G Di Fiore, A Truppo, E Langella, E Vullo, D Supuran, CT Monti, SM
Published in
Journal of Enzyme Inhibition and Medicinal Chemistry
Carbonic anhydrases (CAs) are ubiquitous metallo-enzymes that catalyse the reversible hydration of carbon dioxide to bicarbonate and proton. In humans there are 15 isoforms among which only 12 are catalytically active. Since active human (h) CAs show different efficiency, the understanding of the molecular determinants affecting it is a matter of d...
Ingles Garces, Alvaro H Au, Lewis Mason, Robert Thomas, Jennifer Larkin, James
Published in
Expert Opinion on Investigational Drugs
Introduction: Immunotherapy has revolutionized the treatment of cancer. Given this growing success, at the same time, there are significant limitations and unanswered questions concerning response rates, duration of therapy, why some patients respond and others do not, and if combining different immune-agents would overcome this lack of response, i...
Lu, X Yang, B Yu, H Hu, X Nie, J Wan, B Zhang, M Lü, C
Published in
Pharmaceutical Biology
Context: Neuroligin-1 (NLGN1) is a cell adhesion protein located on the excitatory postsynaptic membrane. β-Amyloid (Aβ)-induced neuroinflammation decreases NLGN1 expression through epigenetic mechanisms. Triptolide (T10) and tripchlorolide (T4) exert protective effects on synapses in Alzheimer's disease (AD) mice, but the mechanisms remain unclear...
Wang, J. Wang, Y. Sun, X. Liu, D. Huang, C. Wu, J. Yang, C. Zhang, Q.
Published in
Artificial Cells Nanomedicine and Biotechnology
A dual-layer biomimetic cartilage scaffold was prepared by mimicking the structural design, chemical cues and mechanical characteristics of mature articular cartilage. The surface layer was made from collagen (COL), chitosan (CS) and hyaluronic acid sodium (HAS). The transitional layer with microtubule array structure was prepared with COL, CS and ...
Ikeda, Atsushi Ohno, Giichiro Otani, Shinji Watanabe, Kentaro Imura, Satoshi
Published in
International Journal of Circumpolar Health
This study aimed to evaluate disease and injury trends among wintering members of the Japanese Antarctic Research Expedition. Obtained information is indispensable to the advancement of medical system and research. Summation was performed based on medical records of reports prepared by each expedition over the period 1956–2016. The clinical departm...
Eun Lee, K Bharadwaj, S Yadava, U Gu Kang, S
Published in
Journal of Enzyme Inhibition and Medicinal Chemistry
Skin ageing results from enhanced activation of intracellular enzymes such as collagenases, elastases and tyrosinase, stimulated by intrinsic ageing and photoageing factors. Recently, caffeine-based cosmetics are introduced that demonstrates to slow down skin photoageing process. However, no attempts have been done so for to understand caffeine fun...
Miettunen, Jouko Haapea, Marianne Björnholm, Lassi Huhtaniska, Sanna Juola, Teija Kinnunen, Lotta Lehtiniemi, Heli Lieslehto, Johannes Rautio, Nina Nordström, Tanja
...
Published in
International Journal of Circumpolar Health
The Northern Finland Birth Cohort 1986 is a large population-based birth cohort, which aims to promote health and wellbeing of the population. In this paper, we systematically review the psychiatric research performed in the cohort until today, i.e. at the age of 32 years of the cohort (2018). We conducted a systematic literature search using the d...
