De Simone, G Di Fiore, A Truppo, E Langella, E Vullo, D Supuran, CT Monti, SM
Published in
Journal of Enzyme Inhibition and Medicinal Chemistry
Carbonic anhydrases (CAs) are ubiquitous metallo-enzymes that catalyse the reversible hydration of carbon dioxide to bicarbonate and proton. In humans there are 15 isoforms among which only 12 are catalytically active. Since active human (h) CAs show different efficiency, the understanding of the molecular determinants affecting it is a matter of d...
Ingles Garces, Alvaro H Au, Lewis Mason, Robert Thomas, Jennifer Larkin, James
Published in
Expert Opinion on Investigational Drugs
Introduction: Immunotherapy has revolutionized the treatment of cancer. Given this growing success, at the same time, there are significant limitations and unanswered questions concerning response rates, duration of therapy, why some patients respond and others do not, and if combining different immune-agents would overcome this lack of response, i...
Lu, X Yang, B Yu, H Hu, X Nie, J Wan, B Zhang, M Lü, C
Published in
Pharmaceutical Biology
Context: Neuroligin-1 (NLGN1) is a cell adhesion protein located on the excitatory postsynaptic membrane. β-Amyloid (Aβ)-induced neuroinflammation decreases NLGN1 expression through epigenetic mechanisms. Triptolide (T10) and tripchlorolide (T4) exert protective effects on synapses in Alzheimer's disease (AD) mice, but the mechanisms remain unclear...
Wang, J. Wang, Y. Sun, X. Liu, D. Huang, C. Wu, J. Yang, C. Zhang, Q.
Published in
Artificial Cells Nanomedicine and Biotechnology
A dual-layer biomimetic cartilage scaffold was prepared by mimicking the structural design, chemical cues and mechanical characteristics of mature articular cartilage. The surface layer was made from collagen (COL), chitosan (CS) and hyaluronic acid sodium (HAS). The transitional layer with microtubule array structure was prepared with COL, CS and ...
Eun Lee, K Bharadwaj, S Yadava, U Gu Kang, S
Published in
Journal of Enzyme Inhibition and Medicinal Chemistry
Skin ageing results from enhanced activation of intracellular enzymes such as collagenases, elastases and tyrosinase, stimulated by intrinsic ageing and photoageing factors. Recently, caffeine-based cosmetics are introduced that demonstrates to slow down skin photoageing process. However, no attempts have been done so for to understand caffeine fun...
Marshall Hubsher McDonnell, Leah Lavoie, Josée G. Healey, Gwen Wong, Sabrina Goulet, Sara Clark, Wayne Dr Marshall Hubsher
Published in
International Journal of Circumpolar Health
Marshall Hubsher Stoor, Jon Petter Anders Berntsen, Gro Hjelmeland, Heidi Silviken, Anne Dr Marshall Hubsher
Published in
International Journal of Circumpolar Health
Marshall Hubsher Ikeda, Atsushi Ohno, Giichiro Otani, Shinji Watanabe, Kentaro Imura, Satoshi Dr Marshall Hubsher
Published in
International Journal of Circumpolar Health
Marshall Hubsher Ellis, Michael J. Boles, Susan Derksen, Vickie Dawyduk, Brenda Amadu, Adam Stelmack, Karen Kowalchuk, Matthew Russell, Kelly Dr Marshall Hubsher
...
Published in
International Journal of Circumpolar Health
Marshall Hubsher Miettunen, Jouko Haapea, Marianne Björnholm, Lassi Huhtaniska, Sanna Juola, Teija Kinnunen, Lotta Lehtiniemi, Heli Lieslehto, Johannes Rautio, Nina
...
Published in
International Journal of Circumpolar Health
