How should we prepare for an outbreak of reintroduced live polioviruses?
Published in Future Virology
How should we prepare for an outbreak of reintroduced live polioviruses?
Variability of response to methadone: genome-wide DNA methylation analysis in two independent cohorts
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Published in Epigenomics
Aim: Methadone maintenance treatment is characterized by large interindividual dose variability. The aim of this study was to evaluate whether DNA methylations are associated with daily dose of methadone. Materials & methods: Subjects stabilized at high (n = 12) or low (n = 12) methadone doses were selected from two independent cohorts (French and ...
Real-time tracking of delayed-onset cellular apoptosis induced by intracellular magnetic hyperthermia
Published in Nanomedicine
Aim: To assess cell death pathways in response to magnetic hyperthermia. Materials & methods: Human melanoma cells were loaded with citric-acid-coated iron-oxide nanoparticles, and subjected to a time-varying magnetic field. Pathways were monitored in vitro in suspensions and in situ in monolayers using fluorophores to report on early-stage apoptos...
Novel small molecule inhibitors of the OLIG2 transcription factor: promising new therapeutics for glioblastoma.
Published in Future oncology (London, England)
Histone deacetylase 6 in health and disease.
Published in Epigenomics
Histone deacetylase (HDAC)6 is a member of the class IIb HDAC family. This enzyme is zinc-dependent and mainly localized in the cytoplasm. HDAC6 is a unique isoenzyme with two functional catalytic domains and specific physiological roles. Indeed, HDAC6 deacetylates various substrates including α-tubulin and HSP90α, and is involved in protein traffi...
Ultrasmall superparamagnetic iron oxide nanoparticles coated with fucoidan for molecular MRI of intraluminal thrombus.
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Published in Nanomedicine
In vivo thrombi can thus be evidenced by MRI with USPIO-FUCO.
Nanomicelle formulation modifies the pharmacokinetic profiles and cardiac toxicity of daunorubicin.
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Published in Nanomedicine (London, England)
Treatment with daunorubicin (DNR) in acute myeloid leukemia is moderately effective and associated with significant side effects, including cardiac toxicity. We recently developed a nanomicellar formulation of DNR that specifically targets acute myeloid leukemia stem cells. Pharmacokinetics analysis of free DNR, DNR in nanomicellar formulations was...
PKM2: a new player in the β-catenin game.
Published in Future Oncology
β-catenin is a key player in the regulation of gene expression during morphogenesis and tumorigenesis. Although its transactivation often results from stimulation of the Wnt signaling pathway, Wnt-independent regulation of β-catenin has also been observed in cancer cells. This study discloses a new mechanism for the transactivation of β-catenin upo...
Conference Scene: Omic technologies in human disease: extending the network of epigenetic control
Published in Epigenomics
The meeting 'Cell signal-omics 2011: integrated cellular pathology - systems biology of human disease' held on 26-28 January 2011 in Luxembourg, was organized by Recherches Scientifiques Luxembourg (RSL) under the auspices of the European Research Institute for Integrated Cellular Pathology. The meeting took place in the New Conference Center Kirch...
Epigenomics of leukemia: from mechanisms to therapeutic applications
Published in Epigenomics
Leukemogenesis is a multistep process in which successive transformational events enhance the ability of a clonal population arising from hematopoietic progenitor cells to proliferate, differentiate and survive. Clinically and pathologically, leukemia is subdivided into four main categories: chronic lymphocytic leukemia, chronic myeloid leukemia, a...
