Real-time tracking of delayed-onset cellular apoptosis induced by intracellular magnetic hyperthermia
Published in Nanomedicine
Novel small molecule inhibitors of the OLIG2 transcription factor: promising new therapeutics for glioblastoma.
Published in Future oncology (London, England)
Variability of response to methadone: genome-wide DNA methylation analysis in two independent cohorts
...Published in Epigenomics
Histone deacetylase 6 in health and disease
Published in Epigenomics
Histone deacetylase (HDAC)6 is a member of the class IIb HDAC family. This enzyme is zinc-dependent and mainly localized in the cytoplasm. HDAC6 is a unique isoenzyme with two functional catalytic domains and specific physiological roles. Indeed, HDAC6 deacetylates various substrates including α-tubulin and HSP90α, and is involved in protein traffi...
Conference Scene: Omic technologies in human disease: extending the network of epigenetic control
Published in Epigenomics
The meeting 'Cell signal-omics 2011: integrated cellular pathology - systems biology of human disease' held on 26-28 January 2011 in Luxembourg, was organized by Recherches Scientifiques Luxembourg (RSL) under the auspices of the European Research Institute for Integrated Cellular Pathology. The meeting took place in the New Conference Center Kirch...
Epigenomics of leukemia: from mechanisms to therapeutic applications
Published in Epigenomics
Leukemogenesis is a multistep process in which successive transformational events enhance the ability of a clonal population arising from hematopoietic progenitor cells to proliferate, differentiate and survive. Clinically and pathologically, leukemia is subdivided into four main categories: chronic lymphocytic leukemia, chronic myeloid leukemia, a...
Scientists' perception of ethical issues in nanomedicine: a case study.
Published in Nanomedicine
Our findings that scientists are motivated to reflect on ethical issues in their work, can contribute to the design of new strategies, including training programs, to engage scientists in ethical discussion and stimulate their responsibility as nanomedicine practitioners.
Human papillomavirus vaccines: new tools for accelerating cervical cancer prevention in developing countries.
Published in Immunotherapy
Despite the available knowledge and tools to prevent cervical cancer, it remains the second most common cancer in women, with four-fifths of the cases occurring in developing countries. Projections are for a 90% increase in global cervical cancer cases by 2020 if no additional public-health interventions are implemented. Prophylactic human papillom...
Hard out there: understanding archaeal virus biology
Published in Future Virology
KEYWORDS • Archaea • hyperthermophiles • Sulfolobus rod-shaped virus 2 • virus evolution • virus–host interactions Each of the three domains of life, Archaea, Bacteria and Eukarya, is associated with a specific virosphere. Despite the fact that archaeal viruses represent only a minute portion of the characterized virosphere, they have recently gain...
Strategies for overcoming the blood-brain barrier for the treatment of brain metastases.
Published in CNS Oncology
The era of targeted therapy for cancer has been punctuated by some resounding successes, but with few exceptions, metastases to the brain remain frustratingly difficult to treat. It is increasingly apparent that old concerns regarding the ability of therapeutic agents to penetrate the blood-brain barrier have not been brushed aside by high-affinity...
