Pérez-García, José Manuel Gebhart, Geraldine Borrego, Manuel Ruiz Schmid, Peter Marmé, Frederik Prat, Aleix Dalenc, Florence Kerrou, Khaldoun Colleoni, Marco Braga, Sofía
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Published in
Future Oncology
This is a summary of a publication about the PHERGain study, which was published in The Lancet Oncology in May 2021. The study includes 376 women with a type of breast cancer called HER2-positive breast cancer that can be removed by surgery. In the study, researchers wanted to learn if participants could be treated with two medicines called trastuz...
Thompson, Kimberly M Tebbens, Radboud J Duintjer
Published in
Future Virology
Cynthia Marie-Claire Crettol, Severine Cagnard, Nicolas Bloch, Vanessa Mouly, Stéphane Jean-Louis Laplanche Frank Bellivier Lepine, Jean-Pierre Eap, Chin Vorspan, Florence
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Published in
Epigenomics
Aim: Methadone maintenance treatment is characterized by large interindividual dose variability. The aim of this study was to evaluate whether DNA methylations are associated with daily dose of methadone. Materials & methods: Subjects stabilized at high (n = 12) or low (n = 12) methadone doses were selected from two independent cohorts (French and ...
Published in
Nanomedicine
Aim: To assess cell death pathways in response to magnetic hyperthermia. Materials & methods: Human melanoma cells were loaded with citric-acid-coated iron-oxide nanoparticles, and subjected to a time-varying magnetic field. Pathways were monitored in vitro in suspensions and in situ in monolayers using fluorophores to report on early-stage apoptos...
Alton, Gordon Kesari, Santosh
Published in
Future oncology (London, England)
Seidel, Carole Schnekenburger, Michael Dicato, Mario Diederich, Marc
Published in
Epigenomics
Histone deacetylase (HDAC)6 is a member of the class IIb HDAC family. This enzyme is zinc-dependent and mainly localized in the cytoplasm. HDAC6 is a unique isoenzyme with two functional catalytic domains and specific physiological roles. Indeed, HDAC6 deacetylates various substrates including α-tubulin and HSP90α, and is involved in protein traffi...
Suzuki, Michimasa Bachelet-Violette, Laure Rouzet, François Beilvert, Anne Autret, Gwennhael Maire, Murielle Menager, Christine Louedec, Liliane Choqueux, Christine Saboural, Pierre
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Published in
Nanomedicine
In vivo thrombi can thus be evidenced by MRI with USPIO-FUCO.
Zhang, Hongyong Li, Yuanpei Lin, Tzu-Yin Xiao, Kai Haddad, Ashraf S Henderson, Paul T Jonas, Brian A Chen, Mingyi Xiao, Wenwu Liu, Ruiwu
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Published in
Nanomedicine (London, England)
Treatment with daunorubicin (DNR) in acute myeloid leukemia is moderately effective and associated with significant side effects, including cardiac toxicity. We recently developed a nanomicellar formulation of DNR that specifically targets acute myeloid leukemia stem cells. Pharmacokinetics analysis of free DNR, DNR in nanomicellar formulations was...
Canal, Frédéric Christine Perret
Published in
Future Oncology
β-catenin is a key player in the regulation of gene expression during morphogenesis and tumorigenesis. Although its transactivation often results from stimulation of the Wnt signaling pathway, Wnt-independent regulation of β-catenin has also been observed in cancer cells. This study discloses a new mechanism for the transactivation of β-catenin upo...
Michael Schnekenburger Marc Diederich
Published in
Epigenomics
The meeting 'Cell signal-omics 2011: integrated cellular pathology - systems biology of human disease' held on 26-28 January 2011 in Luxembourg, was organized by Recherches Scientifiques Luxembourg (RSL) under the auspices of the European Research Institute for Integrated Cellular Pathology. The meeting took place in the New Conference Center Kirch...
