Farhangnia, Pooya Ghomi, Shamim Mollazadeh Akbarpour, Mahzad Delbandi, Ali-Akbar
Published in
Frontiers in Immunology
Antibody-based cancer immunotherapy has become a powerful asset in the arsenal against malignancies. In this regard, bispecific antibodies (BsAbs) are a ground-breaking novel approach in the therapy of cancers. Recently, BsAbs have represented a significant advancement in improving clinical outcomes. BsAbs are designed to target two different antig...
Pooya Farhangnia Ghomi, Shamim Mollazadeh Mollazadehghomi, Shabnam Nickho, Hamid Akbarpour, Mahzad Delbandi, Ali-Akbar
Published in
Frontiers in Immunology
The signaling lymphocytic activation molecule (SLAM) family receptors were discovered in immune cells for the first time. The SLAM-family receptors are a significant player in cytotoxicity, humoral immune responses, autoimmune diseases, lymphocyte development, cell survival, and cell adhesion. There is growing evidence that SLAM-family receptors ha...
Salas-Huetos, Albert Bonet, Sergi Ribas-Maynou, Jordi
Published in
Frontiers in Cell and Developmental Biology
Salinas Martínez, Ana María Juárez Montes, Angélica Gabriela Ramírez Morado, Yesenia Cordero Franco, Hid Felizardo Guzmán de la Garza, Francisco Javier Hernández Oyervides, Luis Carlos Núñez Rocha, Georgina Mayela
Published in
Frontiers in Public Health
Introduction Information on treatment expectations in diabetes is scarce for Mexican and Latino populations. We determined idealistic, realistic, and unrealistic expectations for metformin, insulin, and glyburide in primary care. We also explored the association between sociodemographic attributes, time since diagnosis, and expectations. Methods Th...
Na, Sijia Cui, Hao Guo, Zhichen Liang, Xiang Sakran, Karim Ahmed Guo, Xiaomei Li, Xingqiang Xie, Linyang Zhu, Yifei Qi, Hong
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Published in
Frontiers in Oncology
Background Mena, a cytoskeletal regulatory protein, is involved in actin-based regulation of cell motility and adhesion, and contributes to tumor invasion and metastasis. However, the role of Mena in oral squamous cell carcinoma remains unclear. This is the first research focusing on the prognostic value of Mena in OSCC. In this study, we aimed to ...
Vaughan-Jackson, Alun Stodolak, Szymon Ebrahimi, Kourosh H. Johnson, Errin Reardon, Paul K. Dupont, Maeva Zhang, Shengpan McCullagh, James S. O. James, William S.
Published in
Frontiers in Immunology
Macrophage distribution density is tightly regulated within the body, yet the importance of macrophage crowding during in vitro culture is largely unstudied. Using a human induced pluripotent stem cell (iPSC)-derived macrophage model of tissue resident macrophages, we characterize how increasing macrophage culture density changes their morphology a...
Fathman, C. Garrison Yip, Linda Gómez-Martín, Diana Yu, Mang Seroogy, Christine M. Hurt, Clarence R. Lin, Jack T. Jenks, Jennifer A. Nadeau, Kari C. Soares, Luis
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Published in
Frontiers in Immunology
Regulatory T cells (Tregs) normally maintain self-tolerance. Tregs recognize “self” such that when they are not working properly, such as in autoimmunity, the immune system can attack and destroy one’s own tissues. Current therapies for autoimmunity rely on relatively ineffective and too often toxic therapies to “treat” the destructive inflammation...
Hirai, Hiroyuki Nagao, Masanori Ohira, Tetsuya Maeda, Masaharu Okazaki, Kanako Nakano, Hironori Hayashi, Fumikazu Harigane, Mayumi Suzuki, Yuriko Takahashi, Atsushi
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Published in
Frontiers in Endocrinology
Background The burden of psychological distress and post-traumatic stress disorder (PTSD) has been suggested as a factor in developing type 2 diabetes mellitus. However, longitudinal features in psychological distress- and PTSD-related new-onset diabetes mellitus have not been thoroughly evaluated. Methods The association between probable depressio...
Gonçalves, Sónia P. Vieira dos Santos, Joana Figueiredo-Ferraz, Hugo Gil-Monte, Pedro R. Carlotto, Mary Sandra
Published in
Frontiers in Psychology
Park, Jin-Sung Kim, Seung-Hyun Kim, Yun-Soon Kwon, Euna Lim, Hyun-Jin Han, Kang-Min Choi, Yang-Kyu Jung, Chul-Woo Kang, Byeong-Cheol
Published in
Frontiers in Pharmacology
Lac dye is a natural colorant derived mainly from the insect Kerria lacca (Kerr) and has been used in food and beverage as a red-coloring additive. Despite its increasing use for human consumption as an alternative for allergy-associated cochineal, its toxicity profile remained incomplete to sufficiently assess its safety for the intended use. In t...