Scrimshire, Ashley B. Fairhurst, Caroline McDaid, Catriona Torgerson, David J.
Published in
F1000Research
Perioperative blood transfusion is associated with poorer postoperative outcomes following hip and knee replacement surgery. Evidence for the effectiveness of some measures aimed at reducing blood transfusions in this setting are limited and often rely on weak pre-post study designs. Quasi-experimental study designs such as interrupted time series ...
O'Mahony, Breda Kerins, Claire Murrin, Celine Kelly, Colette
Published in
HRB open research
Background: The importance of nutrition during childhood and the high prevalence of child and adolescence obesity has resulted in several countries implementing nutritional standards for school food as a way of providing healthy school food environments. Yet there has been less focus on the barriers and facilitators influencing the process of imple...
Menéndez, Clara Quintó, Llorenç Castillo, Paola Carrilho, Carla Ismail, Mamudo R Lorenzoni, Cesaltina Fernandes, Fabiola Hurtado, Juan Carlos Rakislova, Natalia Munguambe, Khátia
...
Published in
Gates open research
Background: Accurate information on causes of death (CoD) is essential to estimate burden of disease, track global progress, prioritize cost-effective interventions, and inform policies to reduce mortality. In low-income settings, where a significant proportion of deaths take place at home or in poorly-resourced peripheral health facilities, data o...
Norton, Alice Bucher, Adrian Antonio, Emilia Advani, Nicole Grund, Henrike Mburu, Sheila Clegg, Emma Gollish, Marguerite Jabin, Nusrat Scott, Laura
...
Published in
Wellcome Open Research
Background: The coronavirus disease 2019 (COVID-19) has resulted in an unprecedented research response, demonstrating exceptional examples of rapid research and collaboration. There is however a need for greater coordination, with limited resources and the shifting global nature of the pandemic resulting in a proliferation of research projects unde...
Byrne, David Fahey, Tom Moriarty, Frank
Published in
HRB Open Research
Background: Sacubitril/valsartan is a first-in-class angiotensin-receptor neprilysin inhibitor used to treat heart failure. The evidence for this novel medication is largely based on one pivotal phase III trial which was stopped early due to significant clinical benefits being shown. However potential limitations in trial design have been highlight...
Endo, Akira Leclerc, Quentin J. Knight, Gwenan M. Medley, Graham F. Atkins, Katherine E. Funk, Sebastian Kucharski, Adam J.
Published in
Wellcome Open Research
Introduction: Contact tracing has the potential to control outbreaks without the need for stringent physical distancing policies, e.g. civil lockdowns. Unlike forward contact tracing, backward contact tracing identifies the source of newly detected cases. This approach is particularly valuable when there is high individual-level variation in the nu...
Misra, Usha K. Kalita, Jayantee
Published in
Wellcome Open Research
Hyponatremia is the commonest electrolyte abnormality in hospitalized patients and is associated with poor outcome. Hyponatremia is categorized on the basis of serum sodium into severe (
Foley, Louise Larkin, James Lombard-Vance, Richard Murphy, Andrew W Molloy, Gerard J
Published in
HRB open research
Introduction: Patients with multimorbidity are expected to adhere to complex medication regimens in order to manage their multiple chronic conditions. It has been reported the likelihood of adherence decreases as patients are prescribed more medications. Much medication adherence research to date is dominated by a single-disease focus, which is at ...
Flynn, Jeannie Alkaff, Firas Farisi Sukmajaya, William Putera Salamah, Sovia
Published in
F1000Research
Background: Determination of stunting and wasting always uses the WHO growth standard in Indonesia. However, it is believed that Indonesian children are "below" the global standard, thus the WHO standard is not reliable to present the actual prevalence. This study aims to compare the prevalence and determinants of stunting and underweight using WHO...
McKay, Andrew J. Jones, Ashley P. Gamble, Carrol L. Farmer, Andrew J. Williamson, Paula R.
Published in
F1000Research
Routinely collected data about health in medical records, registries and hospital activity statistics is now routinely collected in an electronic form. The extent to which such sources of data are now being routinely accessed to deliver efficient clinical trials, is unclear. The aim of this study was to ascertain current practice amongst a United K...
