Rodriguez, Patricia J Roberts, D Allen Meisner, Julianne Sharma, Monisha Owiredu, Morkor Newman Gomez, Bertha Mello, Maeve B Bobrik, Alexey Vodianyk, Arkadii Storey, Andrew
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Published in
The Lancet. Global health
Dual HIV and syphilis testing might help to prevent mother-to-child transmission (MTCT) of HIV and syphilis through increased case detection and treatment. We aimed to model and assess the cost-effectiveness of dual testing during antenatal care in four countries with varying HIV and syphilis prevalence. In this modelling study, we developed Markov...
Sartorius, Benn Cano, Jorge Simpson, Hope Tusting, Lucy S Marczak, Laurie B Miller-Petrie, Molly K Kinvi, Boniface Zoure, Honorat Mwinzi, Pauline Hay, Simon I
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Published in
The Lancet. Global health
Driven by global targets to eliminate soil-transmitted helminths as a public health problem, governments have rapidly rolled out control programmes using school and community-based platforms. To justify and target ongoing investment, quantification of impact and identification of remaining high-risk areas are needed. We aimed to assess regional pro...
Trude, Angela C B Richter, Linda M Behrman, Jere R Stein, Aryeh D Menezes, Ana M B Black, Maureen M
Published in
The Lancet. Child & Adolescent Health
Background Millions of children globally are at risk of not reaching their developmental potential because of early adversities. We hypothesised that responsive caregiving and learning opportunities, components of nurturing care, at pre-school ages might mitigate the effects of adversities. Methods We analysed longitudinal birth cohort data from Br...
Coll, Francesc Raven, Kathy E Knight, Gwenan M Blane, Beth Harrison, Ewan M Leek, Danielle Enoch, David A Brown, Nicholas M Parkhill, Julian Peacock, Sharon J
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Published in
The Lancet. Microbe
Background Whole-genome sequencing (WGS) can be used in genomic epidemiology investigations to confirm or refute outbreaks of bacterial pathogens, and to support targeted and efficient infection control interventions. We aimed to define a genetic relatedness cutoff, quantified as a number of single-nucleotide polymorphisms (SNP), for meticillin-res...
Hill, Rebecca M Richardson, Stacey Schwalbe, Edward C Hicks, Debbie Lindsey, Janet C Crosier, Stephen Rafiee, Gholamreza Grabovska, Yura Wharton, Stephen B Jacques, Thomas S
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Published in
The Lancet. Child & adolescent health
Disease relapse occurs in around 30% of children with medulloblastoma, and is almost universally fatal. We aimed to establish whether the clinical and molecular characteristics of the disease at diagnosis are associated with the nature of relapse and subsequent disease course, and whether these associations could inform clinical management. In this...
Azman, Andrew S Lauer, Stephen A Bhuiyan, Taufiqur Rahman Luquero, Francisco J Leung, Daniel T Hegde, Sonia T Harris, Jason B Paul, Kishor Kumar Khaton, Fatema Ferdous, Jannatul
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Published in
The Lancet. Microbe
Background Pandemic Vibrio cholerae from cholera-endemic countries around the Bay of Bengal regularly seed epidemics globally. Without reducing cholera in these countries, including Bangladesh, global cholera control might never be achieved. Little is known about the geographical distribution and magnitude of V cholerae O1 transmission nationally. ...
Nove, Andrea Friberg, Ingrid K de Bernis, Luc McConville, Fran Moran, Allisyn C Najjemba, Maria ten Hoope-Bender, Petra Tracy, Sally Homer, Caroline S E
Published in
The Lancet. Global Health
Background Strengthening the capacity of midwives to deliver high-quality maternal and newborn health services has been highlighted as a priority by global health organisations. To support low-income and middle-income countries (LMICs) in their decisions about investments in health, we aimed to estimate the potential impact of midwives on reducing ...
Tegbaru, Amare Menkir, Abebe Nasser Baco, Mohamed Idrisou, Latifou Sissoko, Dioukou Eyitayo, Ayinde O. Abate, Tsedeke Tahirou, Abdoulaye
Published in
World Development Perspectives
Maize is the most important cereal in Sub Saharan Africa; however, yields are significantly lower than those possible with improvements in cultivars and management. Maize breeding programs need to produce material with improved resistance to increasing environmental stresses and incorporate the man and women farmer preferred traits that relate to y...
Yang, C.Y. Chanalaris, A. Bonelli, S. McClurg, O. Hiles, G. Lorenzatti Cates, A.L. Zarebska, J. Miotla Vincent, T.L. Day, M.L. Müller, S.A.
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Published in
Osteoarthritis and Cartilage Open
Objective The adamalysin metalloproteinase 15 (ADAM15) has been shown to protect against development of osteoarthritis in mice. Here, we have investigated factors that control ADAM15 levels in cartilage. Design Secretomes from wild-type and Adam15 −/− chondrocytes were compared by label-free quantitative mass spectrometry. mRNA was isolated from mu...
de Sousa Valente, João Alawi, Khadija M. Keringer, Patrik Bharde, Sabah Ayaz, Faseeha Saleque, Nurjahan Kodji, Xenia Thapa, Dibesh Argunhan, Fulye Brain, Susan D.
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Published in
Osteoarthritis and Cartilage Open
Introduction Osteo-arthritis (OA) involves joint degradation and usually pain; with mechanisms poorly understood and few treatment options. There is evidence that the transient receptor potential canonical 5 (TRPC5) mRNA expression is reduced in OA patients’ synovia. Here we examine the profile of TRPC5 in DRG and involvement in murine models of OA...
