Samantha Haller Franchet, Adrien Hakkim, Abdul Chen, Jing Drenkard, Eliana Yu, Shen Schirmeier, Stefanie Li, Zi Martins, Nelson Ausubel, Frederick M
...
Published in
EMBO reports
When Drosophila melanogaster feeds on Pseudomonas aeruginosa , some bacteria cross the intestinal barrier and eventually proliferate in the hemocoel. This process is limited by hemocytes through phagocytosis. P. aeruginosa requires the quorum‐sensing regulator RhlR to elude the cellular immune response of the fly. RhlI synthesizes the autoinducer s...
Lazar‐Stefanita, Luciana Scolari, Vittore F Guillaume Mercy Muller, Héloise Guérin, Thomas M Thierry, Agnès Mozziconacci, Julien Koszul, Romain
Published in
The EMBO Journal
Duplication and segregation of chromosomes involves dynamic reorganization of their internal structure by conserved architectural proteins, including the structural maintenance of chromosomes (SMC) complexes cohesin and condensin. Despite active investigation of the roles of these factors, a genome‐wide view of dynamic chromosome architecture at bo...
Harhouri, Karim Navarro, Claire Depetris, Danielle Mattei, Marie‐Geneviève Nissan, Xavier Cau, Pierre De Sandre‐Giovannoli, Annachiara Lévy, Nicolas
Published in
EMBO Molecular Medicine
Peleg, Shahaf
Published in
EMBO Reports
Old age is associated with a progressive decline of mitochondrial function and changes in nuclear chromatin. However, little is known about how metabolic activity and epigenetic modifications change as organisms reach their midlife. Here, we assessed how cellular metabolism and protein acetylation change during early aging in Drosophila melanogaste...
Jean-Pierre de Villartay
Published in
EMBO Molecular Medicine
Mutations in the XRCC4 gene have been recently identified through whole-exome sequencing (WES). While the overall clinical presentation of the patients (severe short stature, microcephaly, gonadal failure) generally conforms with what is expected for the defect of a critical non-homologous end-joining (NHEJ) DNA repair factor, the absence of conseq...
Lau, Agnes McDonald, Alex Daude, Nathalie Mays, Charles E Walter, Eric D Aglietti, Robin Mercer, Robert C C Wohlgemuth, Serene van der Merwe, Jacques Yang, Jing
...
Published in
EMBO molecular medicine
The cellular prion protein (PrP(C)) comprises a natively unstructured N-terminal domain, including a metal-binding octarepeat region (OR) and a linker, followed by a C-terminal domain that misfolds to form PrP(S) (c) in Creutzfeldt-Jakob disease. PrP(C) β-endoproteolysis to the C2 fragment allows PrP(S) (c) formation, while α-endoproteolysis blocks...
Van Praet, Jens T Donovan, Erin Vanassche, Inge Drennan, Michael B Windels, Fien Dendooven, Amélie Allais, Liesbeth Cuvelier, Claude A van de Loo, Fons Norris, Paula S
...
Published in
The EMBO Journal
Antinuclear antibodies are a hallmark feature of generalized autoimmune diseases, including systemic lupus erythematosus and systemic sclerosis. However, the processes underlying the loss of tolerance against nuclear self-constituents remain largely unresolved. Using mice deficient in lymphotoxin and Hox11, we report that approximately 25% of mice ...
Kushwah, Rahul Guezguez, Borhane Lee, Jung Bok Hopkins, Claudia I Bhatia, Mickie Borhane Guezguez, PhD., MSc.
Published in
EMBO Reports
The Notch signaling pathway is evolutionarily conserved across species and plays an important role in regulating cell differentiation, proliferation, and survival. It has been implicated in several different hematopoietic processes including early hematopoietic development as well as adult hematological malignancies in humans. This review focuses o...
Uzan, Benjamin Poglio, Sandrine Gerby, Bastien Wu, Ching-Lien Gross, Julia Armstrong, Florence Calvo, Julien Cahu, Xavier Deswarte, Caroline Dumont, Florent
...
Published in
EMBO Molecular Medicine
Development of novel therapies is critical for T-cell acute leukaemia (T-ALL). Here, we investigated the effect of inhibiting the MAPK/MEK/ERK pathway on T-ALL cell growth. Unexpectedly, MEK inhibitors (MEKi) enhanced growth of 70% of human T-ALL cell samples cultured on stromal cells independently of NOTCH activation and maintained their ability t...
Diana, Julien Lehuen, Agnès
Published in
EMBO Molecular Medicine
Autoimmune type 1 diabetes (T1D) development results from the interaction between pancreatic β-cells, and the innate and the adaptive immune systems culminating with the destruction of the insulin-secreting β-cells by autoreactive T cells. This diabetogenic course starts during the first postnatal weeks by the infiltration of the pancreatic islets ...
