Durstenfeld, Matthew S Peluso, Michael J Kaveti, Punita Hill, Christopher Li, Danny Sander, Erica Swaminathan, Shreya Arechiga, Victor M Lu, Scott Goldberg, Sarah A
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medRxiv : the preprint server for health sciences
Mechanisms underlying persistent cardiopulmonary symptoms following SARS-CoV-2 infection (post-acute sequelae of COVID-19 "PASC" or "Long COVID") remain unclear. This study sought to elucidate mechanisms of cardiopulmonary symptoms and reduced exercise capacity using advanced cardiac testing. We performed cardiopulmonary exercise testing (CPET), ca...
Escoubas, Caroline C Dorman, Leah C Nguyen, Phi T Lagares-Linares, Christian Nakajo, Haruna Anderson, Sarah R Cuevas, Beatriz Vainchtein, Ilia D Silva, Nicholas J Xiao, Yinghong
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bioRxiv : the preprint server for biology
Microglia are brain resident phagocytes that can engulf synaptic components and extracellular matrix as well as whole neurons. However, whether there are unique molecular mechanisms that regulate these distinct phagocytic states is unknown. Here we define a molecularly distinct microglial subset whose function is to engulf neurons in the developing...
Mallela, Abhishek Chen, Ye Lin, Yen Ting Miller, Ely F Neumann, Jacob He, Zhili Nelson, Kathryn E Posner, Richard G Hlavacek, William S
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medRxiv : the preprint server for health sciences
To characterize Coronavirus Disease 2019 (COVID-19) transmission dynamics in each of the metropolitan statistical areas (MSAs) surrounding Dallas, Houston, New York City, and Phoenix in 2020 and 2021, we extended a previously reported compartmental model accounting for effects of multiple distinct periods of non-pharmaceutical interventions by addi...
Tatham, Lee Kipar, Anja Sharp, Joanne Kijak, Edyta Herriott, Joanne Neary, Megan Box, Helen Gallardo Toledo, Eduardo Valentijn, Anthony Cox, Helen
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bioRxiv : the preprint server for biology
Ronapreve demonstrated clinical application in post-exposure prophylaxis, mild/moderate disease and in the treatment of seronegative patients with severe COVID19 prior to the emergence of the Omicron variant in late 2021. Numerous reports have described loss of in vitro neutralisation activity of Ronapreve and other monoclonal antibodies for BA.1 O...
Zaslavsky, Maxim E Craig, Erin Michuda, Jackson K Ram-Mohan, Nikhil Lee, Ji-Yeun Nguyen, Khoa D Hoh, Ramona A Pham, Tho D Parsons, Ella S Macwana, Susan R
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bioRxiv : the preprint server for biology
Clinical diagnoses rely on a wide variety of laboratory tests and imaging studies, interpreted alongside physical examination findings and the patient's history and symptoms. Currently, the tools of diagnosis make limited use of the immune system's internal record of specific disease exposures encoded by the antigen-specific receptors of memory B c...
Cohen, Phillip DeGrace, Emma J Danziger, Oded Patel, Roosheel S Barrall, Erika A Bobrowski, Tesia Kehrer, Thomas Cupic, Anastasija Miorin, Lisa García-Sastre, Adolfo
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bioRxiv : the preprint server for biology
Single cell RNA sequencing (scRNA-Seq) studies have provided critical insight into the pathogenesis of Severe Acute Respiratory Syndrome CoronaVirus 2 (SARS-CoV-2), the causative agent of COronaVIrus Disease 2019 (COVID-19). scRNA-Seq workflows are generally designed for the detection and quantification of eukaryotic host mRNAs and not viral RNAs. ...
Escalera-Zamudio, Marina Kosakovsky Pond, Sergei L de la Viña, Natalia Martínez Gutiérrez, Bernardo Inward, Rhys P D Thézé, Julien van Dorp, Lucy Castelán-Sánchez, Hugo G Bowden, Thomas A Pybus, Oliver G
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bioRxiv : the preprint server for biology
Comparing the evolution of distantly related viruses can provide insights into common adaptive processes related to shared ecological niches. Phylogenetic approaches, coupled with other molecular evolution tools, can help identify mutations informative on adaptation, whilst the structural contextualization of these to functional sites of proteins m...
Hafiz, Rakibul Gandhi, Tapan Kumar Mishra, Sapna Prasad, Alok Mahajan, Vidur Natelson, Benjamin H Di, Xin Biswal, Bharat B
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bioRxiv : the preprint server for biology
The Coronavirus Disease 2019 (COVID-19) has affected all aspects of life around the world. Neuroimaging evidence suggests the novel coronavirus can attack the central nervous system (CNS), causing cerebro-vascular abnormalities in the brain. This can lead to focal changes in cerebral blood flow and metabolic oxygen consumption rate in the brain. Ho...
Fielding-Miller, Rebecca Karthikeyan, Smruthi Gaines, Tommi Garfein, Richard S Salido, Rodolfo A Cantu, Victor J Kohn, Laura Martin, Natasha K Wynn, Adriane Wijaya, Carrissa
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Published in
medRxiv : the preprint server for health sciences
Schools are high-risk settings for SARS-CoV-2 transmission, but necessary for children's educational and social-emotional wellbeing. Previous research suggests that wastewater monitoring can detect SARS-CoV-2 infections in controlled residential settings with high levels of accuracy. However, its effective accuracy, cost, and feasibility in non-res...
Wydorski, Pawel M Osipiuk, Jerzy Lanham, Benjamin T Tesar, Christine Endres, Michael Engle, Elizabeth Jedrzejczak, Robert Mullapudi, Vishruth Michalska, Karolina Fidelis, Krzysztof
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Published in
bioRxiv : the preprint server for biology
The Papain-like protease (PLpro) is a domain of a multi-functional, non-structural protein 3 of coronaviruses. PLpro cleaves viral polyproteins and posttranslational conjugates with poly-ubiquitin and protective ISG15, composed of two ubiquitin-like (UBL) domains. Across coronaviruses, PLpro showed divergent selectivity for recognition and cleavage...
