Association between severity of COVID-19 symptoms and habitual food intake in adult outpatients
Published in BMJ Nutrition, Prevention & Health
High endothelial venule is a surrogate biomarker for T-cell inflamed tumor microenvironment and prognosis in gastric can...
...Published in Journal for immunotherapy of cancer
High endothelial venule (HEV) is a specialized vasculature for lymphocyte trafficking. While HEVs are frequently observed within gastric cancer (GC), the vascular-immune interaction between HEV and tumor-infiltrating lymphocytes (TILs) has not been well elucidated. In this study, we aimed to unveil the potential value of HEVs as a surrogate marker ...
Functional analysis of peripheral and intratumoral neoantigen-specific TCRs identified in a patient with melanoma.
...Published in Journal for immunotherapy of cancer
Neoantigens derived from somatic mutations correlate with therapeutic responses mediated by treatment with immune checkpoint inhibitors. Neoantigens are therefore highly attractive targets for the development of therapeutic approaches in personalized medicine, although many aspects of their quality and associated immune responses are not yet well u...
Nomogram to predict the outcomes of patients with microsatellite instability-high metastatic colorectal cancer receiving...
...Published in Journal for immunotherapy of cancer
The efficacy of immune checkpoint inhibitors (ICIs) in patients with microsatellite instability (MSI)-high metastatic colorectal cancer (mCRC) is unprecedented. A relevant proportion of subjects achieving durable disease control may be considered potentially 'cured', as opposed to patients experiencing primary ICI refractoriness or short-term clini...
Reducing neuroimaging in first-episode psychosis by facilitating uptake of choosing wisely recommendations: a quality im...
Published in BMJ open quality
STING agonist loaded lipid nanoparticles overcome anti-PD-1 resistance in melanoma lung metastasis via NK cell activatio...
Published in Journal for immunotherapy of cancer
Resistance to an immune checkpoint inhibitor (ICI) is a major obstacle in cancer immunotherapy. The causes of ICI resistance include major histocompatibility complex (MHC)/histocompatibility locus antigen (HLA) class I loss, neoantigen loss, and incomplete antigen presentation. Elimination by natural killer (NK) cells would be expected to be an eff...
Trajectories in HbA1c and other risk factors among adults with type 1 diabetes by age at onset.
...Published in BMJ open diabetes research & care
In type 1 diabetes, potential loss of life-years is greatest in those who are youngest at the time of onset. Using data from a nationwide cohort of patients with type 1 diabetes, we aimed to study risk factor trajectories by age at diagnosis. We stratified 30 005 patients with type 1 diabetes aged 18-75 years into categories based on age at onset: ...
Higher postoperative plasma EV PD-L1 predicts poor survival in patients with gastric cancer.
...Published in Journal for immunotherapy of cancer
The satisfactory prognostic indicator of gastric cancer (GC) patients after surgery is still lacking. Perioperative plasma extracellular vesicular programmed cell death ligand-1 (ePD-L1) has been demonstrated as a potential prognosis biomarker in many types of cancers. The prognostic value of postoperative plasma ePD-L1 has not been characterized. ...
First immunotherapeutic CAR-T cells against the immune checkpoint protein HLA-G.
...Published in Journal for immunotherapy of cancer
CAR-T cells immunotherapy is a breakthrough in the treatment of hematological malignancies such as acute lymphoblastic leukemia (ALL) and B-cell malignancies. However, CAR-T therapies face major hurdles such as the lack of tumor-specific antigen (TSA), and immunosuppressive tumor microenvironment sometimes caused by the tumorous expression of immun...
CXCR6 deficiency impairs cancer vaccine efficacy and CD8+ resident memory T-cell recruitment in head and neck and lung t...
...Published in Journal for immunotherapy of cancer
Resident memory T lymphocytes (TRM) are located in tissues and play an important role in immunosurveillance against tumors. The presence of TRM prior to treatment or their induction is associated to the response to anti-Programmed cell death protein 1 (PD-1)/Programmed death-ligand 1 (PD-L1) immunotherapy and the efficacy of cancer vaccines. Previo...
