Chiu, Chan-Wen Xian, Minghan Stephany, Jenna L. Xia, Xinyi Chiang, Chao-Ching Ren, Fan Tsai, Cheng-Tse Shan, Siang-Sin Liao, Yu-Te Esquivel-Upshaw, Josephine F.
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Published in
Journal of Vacuum Science and Technology. B, Nanotechnology & Microelectronics
The SARS-CoV-2 pandemic has had a significant impact worldwide. Currently, the most common detection methods for the virus are polymerase chain reaction (PCR) and lateral flow tests. PCR takes more than an hour to obtain the results and lateral flow tests have difficulty with detecting the virus at low concentrations. In this study, 60 clinical hum...
Xian, Minghan Chiu, Chan-Wen Carey, Patrick H. IV Fares, Chaker Chen, Liya Wu, Rena Ren, Fan Tsai, Cheng-Tse Shan, Siang-Sin Liao, Yu-Te
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Published in
Journal of Vacuum Science and Technology. B, Nanotechnology & Microelectronics
Leakage of human cerebrospinal fluid (CSF) caused by trauma or other reasons presents exceptional challenges in clinical analysis and can have severe medical repercussions. Conventional test methods, including enzyme-linked immunosorbent assay and immunofixation electrophoresis testing, typically are performed at a few clinical reference laboratori...
Jeong, Hongbae Deng, Jiangdong Bonmassar, Giorgio
Published in
Journal of Vacuum Science and Technology. B, Nanotechnology & Microelectronics
Recently, white-matter fiber tract pathways carrying neural signals through the brain were shown to follow curved, orthogonal grids. This study focuses on how these white-matter fibers may be selectively excited using micromagnetic stimulation ( μ MS), a new type of neuronal stimulation, which generates microscopic eddy currents capable of directio...
Gorman, Brittney L Brunet, Melanie A Kraft, Mary L
Published in
Biointerphases
Strategies that do not require additional characterization to be performed on the sample or the collection of additional secondary ion signals are needed to depth correct 3D SIMS images of cells. Here, we develop a depth correction strategy that uses the pixel intensities in the secondary electron images acquired during negative-ion NanoSIMS depth ...
Xian, Minghan Luo, Hao Xia, Xinyi Fares, Chaker Carey, Patrick H. IV Chiu, Chan-Wen Ren, Fan Shan, Siang-Sin Liao, Yu-Te Hsu, Shu-Min
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Published in
Journal of Vacuum Science and Technology. B, Nanotechnology & Microelectronics
Detection of the SARS-CoV-2 spike protein and inactivated virus was achieved using disposable and biofunctionalized functional strips, which can be connected externally to a reusable printed circuit board for signal amplification with an embedded metal–oxide–semiconductor field-effect transistor (MOSFET). A series of chemical reactions was performe...
Muehe, Anne Nejadnik, Hossein Muehe, Henrik Rosenberg, Jarrett Gharibi, Hassan Saei, Amir Ata Lyu, Shu-Chen Nadeau, Kari C Mahmoudi, Morteza Daldrup-Link, Heike E
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Published in
Biointerphases
Ferumoxytol nanoparticles are being used clinically for the treatment of anemia and molecular imaging in patients. It is well documented that while most patients tolerate ferumoxytol well, a small percentage of patients (i.e., 0.01%) develop severe allergic reactions. The purpose of our proof-of-concept study was to determine whether patients with ...
Wang, Jingtao Pan, Yaokun Wang, Wei Cui, Hongwei Feng, Rui Cui, Xiaoli Gong, Benkui Zhao, Xingchuan Hou, Ning
Published in
Biointerphases
Bioceramic calcium phosphorus (CaP) coatings were prepared on self-designed Mg-xZn-0.6Ca (x = 3.0, 4.5, 6.0 wt. %) alloy by microarc oxidation (MAO). The corrosion resistance, bioactivity, and biodegradability of the CaP coatings prepared on alloys with different zinc (Zn) contents were systematically studied and discussed by potentiodynamic polari...
Kumar, Sachin Paul, Alexandra Chatterjee, Sayantan Pütz, Sabine Nehra, Natasha Wang, Daniel S. Nisar, Arsalan M. Jennings, Christian Parekh, Sapun H.
Published in
Biointerphases
The novel coronavirus caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has reached more than 160 countries and has been declared a pandemic. SARS-CoV-2 infects host cells by binding to the angiotensin-converting enzyme 2 (ACE-2) surface receptor via the spike (S) receptor-binding protein (RBD) on the virus envelope. Global dat...
Samantray, Suman Cheung, David L
Published in
Biointerphases
It has long been recognized that liquid interfaces, such as the air-water interface (AWI), can enhance the formation of protein fibrils. This makes liquid interfaces attractive templates for fibril formation but fully realizing this requires knowledge of protein behavior at interfaces, which is currently lacking. To address this, molecular dynamics...
Poli, Hamish Mutch, Alexandra L. A, Anitha Ivanovski, Saso Vaquette, Cedryck Castner, David G. Gómez-Cerezo, María Natividad Grøndahl, Lisbeth
Published in
Biointerphases
Surface modification of biomaterials is a strategy used to improve cellular and in vivo outcomes. However, most studies do not evaluate the lifetime of the introduced surface layer, which is an important aspect affecting how a biomaterial will interact with a cellular environment both in the short and in the long term. This study evaluated the surf...
