Bienaimé, Frank Muorah, Mordi Yammine, Lucie Burtin, Martine Nguyen, Clément Baron, Willian Garbay, Serge Viau, Amandine Broueilh, Mélanie Blanc, Thomas
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Published in
Journal of the American Society of Nephrology : JASN
In CKD, tubular cells may be involved in the induction of interstitial fibrosis, which in turn, leads to loss of renal function. However, the molecular mechanisms that link tubular cells to the interstitial compartment are not clear. Activation of the Stat3 transcription factor has been reported in tubular cells after renal damage, and Stat3 has be...
Trepiccione, Francesco Gerber, Simon D Grahammer, Florian López-Cayuqueo, Karen I Baudrie, Véronique Păunescu, Teodor G Capen, Diane E Picard, Nicolas Alexander, R Todd Huber, Tobias B
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Published in
Journal of the American Society of Nephrology
ATPase H+-transporting lysosomal accessory protein 2 (Atp6ap2), also known as the (pro)renin receptor, is a type 1 transmembrane protein and an accessory subunit of the vacuolar H+-ATPase (V-ATPase) that may also function within the renin-angiotensin system. However, the contribution of Atp6ap2 to renin-angiotensin-dependent functions remains uncon...
Amrouche, Lucile Desbuissons, Geoffroy Rabant, Marion Sauvaget, Virginia Nguyen, Clément Benon, Aurélien Barre, Pauline Rabaté, Clémentine Lebreton, Xavier Gallazzini, Morgan
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Published in
Journal of the American Society of Nephrology
AKI leads to tubular injury and interstitial inflammation that must be controlled to avoid the development of fibrosis. We hypothesized that microRNAs are involved in the regulation of the balance between lesion formation and adaptive repair. We found that, under proinflammatory conditions, microRNA-146a (miR-146a) is transcriptionally upregulated ...
Aboudehen, K. Kim, M. S. Mitsche, M. Garland, K. Anderson, N. Noureddine, L. Marco Pontoglio Patel, V. Xie, Y. DeBose-Boyd, R.
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Published in
Journal of the American Society of Nephrology
HNF-1β is a tissue-specific transcription factor that is expressed in the kidney and other epithelial organs. Humans with mutations in HNF-1β develop kidney cysts, and HNF-1β regulates the transcription of several cystic disease genes. However, the complete spectrum of HNF-1β-regulated genes and pathways is not known. Here, using chromatin immunopr...
Kruzel-Davila, Etty Shemer, Revital Ofir, Ayala Bavli-Kertselli, Ira Darlyuk-Saadon, Ilona Oren-Giladi, Pazit Wasser, Walter G. Magen, Daniella Zaknoun, Eid Schuldiner, Maya
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Published in
Journal of the American Society of Nephrology
APOL1 harbors C-terminal sequence variants (G1 and G2), which account for much of the increased risk for kidney disease in sub-Saharan African ancestry populations. Expression of the risk variants has also been shown to cause injury to podocytes and other cell types, but the underlying mechanisms are not understood. We used Drosophila melanogaster ...
Aboudehen, Karam Kim, Min Soo Mitsche, Matthew Garland, Kristina Anderson, Norma Noureddine, Lama Marco Pontoglio Patel, Vishal Xie, Yang DeBose-Boyd, Russell
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Published in
Journal of the American Society of Nephrology
HNF-1β is a tissue-specific transcription factor that is expressed in the kidney and other epithelial organs. Humans with mutations in HNF-1β develop kidney cysts, and HNF-1β regulates the transcription of several cystic disease genes. However, the complete spectrum of HNF-1β-regulated genes and pathways is not known. Here, using chromatin immunopr...
Rabant, M. Amrouche, L. Lebreton, X. Aulagnon, F. Benon, A. Sauvaget, V. Bonifay, R. Morin, L. Scemla, A. Delville, M.
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Published in
Journal of the American Society of Nephrology
Urinary levels of C-X-C motif chemokine 9 (CXCL9) and CXCL10 can noninvasively diagnose T cell-mediated rejection (TCMR) of renal allografts. However, performance of these molecules as diagnostic/prognostic markers of antibody-mediated rejection (ABMR) is unknown. We investigated urinary CXCL9 and CXCL10 levels in a highly sensitized cohort of 244 ...
Huynh Cong, Evelyne Bizet, Albane A Boyer, Olivia Woerner, Stéphanie Gribouval, Olivier Filhol, Emilie Arrondel, Christelle Thomas, Sophie Silbermann, Flora Canaud, Guillaume
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Published in
Journal of the American Society of Nephrology
Several genes, mainly involved in podocyte cytoskeleton regulation, have been implicated in familial forms of primary FSGS. We identified a homozygous missense mutation (p.P209L) in the TTC21B gene in seven families with FSGS. Mutations in this ciliary gene were previously reported to cause nephronophthisis, a chronic tubulointerstitial nephropathy...
Lima, Wânia R Parreira, Kleber S Devuyst, Olivier Caplanusi, Adrian N'kuli, Francisca Marien, Benoit Van Der Smissen, Patrick Alves, Pedro M S Verroust, Pierre Christensen, Erik I
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Published in
Journal of the American Society of Nephrology
Epithelial polarization modulates gene expression. The transcription factor zonula occludens 1 (ZO-1)-associated nucleic acid binding protein (ZONAB) can shuttle between tight junctions and nuclei, promoting cell proliferation and expression of cyclin D1 and proliferating cell nuclear antigen (PCNA), but whether it also represses epithelial differe...
Fischer, Evelyne Hiesberger, Thomas Pontoglio, Marco Igarashi, Peter Gong, Yimei Ma, Zhendong Patel, Vishal
Published in
Journal of the American Society of Nephrology
Hepatocyte nuclear factor-1beta (HNF-1beta) is a transcription factor that regulates gene expression in the kidney, liver, pancreas, and other epithelial organs. Mutations of HNF-1beta lead to a syndrome of inherited renal cysts and diabetes and are also a common cause of sporadic renal dysplasia. The full complement of target genes responsible for...