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published by American Society of Nephrology

Lipocalin-2 Exacerbates Lupus Nephritis by Promoting Th1 Cell Differentiation.

Published in Journal of the American Society of Nephrology : JASN

Lipocalin-2 (LCN2) is an indicator of the severity of lupus nephritis (LN) and plays a pivotal role in immune responses, but it is not known if its effect on LN pathogenesis derives from regulating the immune imbalance of T lymphocyte subsets. The expression of LCN2 in T cells and kidneys was assessed in renal biopsies from patients with LN. We inv...

LIM-Nebulette Reinforces Podocyte Structural Integrity by Linking Actin and Vimentin Filaments.

Published in Journal of the American Society of Nephrology : JASN

Maintenance of the intricate interdigitating morphology of podocytes is crucial for glomerular filtration. One of the key aspects of specialized podocyte morphology is the segregation and organization of distinct cytoskeletal filaments into different subcellular components, for which the exact mechanisms remain poorly understood. Cells from rats, m...

Single-Cell RNA Sequencing Reveals mRNA Splice Isoform Switching during Kidney Development.

Published in Journal of the American Society of Nephrology : JASN

During mammalian kidney development, nephron progenitors undergo a mesenchymal-to-epithelial transition and eventually differentiate into the various tubular segments of the nephron. Recently, Drop-seq single-cell RNA sequencing technology for measuring gene expression from thousands of individual cells identified the different cell types in the de...

Single-Cell Transcriptome Profiling of the Kidney Glomerulus Identifies Key Cell Types and Reactions to Injury.

Published in Journal of the American Society of Nephrology : JASN

The glomerulus is a specialized capillary bed that is involved in urine production and BP control. Glomerular injury is a major cause of CKD, which is epidemic and without therapeutic options. Single-cell transcriptomics has radically improved our ability to characterize complex organs, such as the kidney. Cells of the glomerulus, however, have bee...

Improving Care for Patients after Hospitalization with AKI.

Published in Journal of the American Society of Nephrology : JASN

Sympathetic Overactivity in CKD Disrupts Buffering of Neurotransmission by Endothelium-Derived Hyperpolarizing Factor an...

Published in Journal of the American Society of Nephrology : JASN

Hypertension commonly complicates CKD. Vascular smooth muscle cells (VSMCs) of resistance arteries receive signals from the sympathetic nervous system that induce an endothelial cell (EC)-dependent anticontractile response that moderates vasoconstriction. However, the specific role of this pathway in the enhanced vasoconstriction in CKD is unknown....

Coordinated Circulating T Follicular Helper and Activated B Cell Responses Underlie the Onset of Antibody-Mediated Rejec...

Published in Journal of the American Society of Nephrology : JASN

Although antibody-mediated rejection (ABMR) has been long recognized as a leading cause of allograft failure after kidney transplantation, the cellular and molecular processes underlying the induction of deleterious donor-specific antibody (DSA) responses remain poorly understood. Using high-dimensional flow cytometry, in vitro assays, and RNA sequ...

Different eGFR Decline Thresholds and Renal Effects of Canagliflozin: Data from the CANVAS Program.

Published in Journal of the American Society of Nephrology : JASN

Traditionally, clinical trials evaluating effects of a new therapy with creatinine-based renal end points use doubling of serum creatinine (equivalent to a 57% eGFR reduction), requiring large sample sizes. To assess whether eGFR declines

Do-Not-Resuscitate Orders among Patients with ESKD Admitted to the Intensive Care Unit: A Bird's Eye View.

Published in Journal of the American Society of Nephrology : JASN

Reversal of Donor Hepatitis C Virus–Related Mesangial Proliferative GN in a Kidney Transplant Recipient

Published in Journal of the American Society of Nephrology : JASN