Hottz, Eugenio D Martins-Gonçalves, Remy Palhinha, Lohanna Azevedo-Quintanilha, Isaclaudia G de Campos, Mariana M Sacramento, Carolina Q Temerozo, Jairo R Soares, Vinicius Cardoso Dias, Suelen S Gomes Teixeira, Lívia
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Published in
Blood advances
Accumulating evidence into the pathogenesis of COVID-19 highlights a hypercoagulability state with high risk of life-threatening thromboembolic complications. However, the mechanisms of hypercoagulability and their link to hyperinflammation remain poorly understood. Here, we investigate functions and mechanisms of platelet activation and platelet-m...
Cuker, Adam Tseng, Eric K Nieuwlaat, Robby Angchaisuksiri, Pantep Blair, Clifton Dane, Kathryn DeSancho, Maria T Diuguid, David Griffin, Daniel O Kahn, Susan R
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Published in
Blood advances
COVID-19-related acute illness is associated with an increased risk of venous thromboembolism (VTE). These evidence-based guidelines from the American Society of Hematology (ASH) are intended to support patients, clinicians, and other health care professionals in making decisions about the use of anticoagulation in patients with COVID-19. ASH forme...
Spyropoulos, Alex C Lopes, Renato D
Published in
Blood advances
Nicolai, Leo Leunig, Alexander Pekayvaz, Kami Esefeld, Max Anjum, Afra Rath, Justina Riedlinger, Eva Ehreiser, Vincent Mader, Magdalena Eivers, Luke
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Published in
Blood
Vaccines against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) are based on a range of novel platforms, with adenovirus-based approaches (like ChAdOx1 nCov-19) being one of them. Recently, a novel complication of SARS-CoV-2-targeted adenovirus vaccines has emerged: immune thrombocytopenia, either isolated, or accompanied by thrombosi...
Thomas, Mari R Scully, Marie
Published in
Blood
Infection with the SARS-CoV-2 virus, resulting in COVID-19 disease, has presented a unique scenario associated with high rates of thrombosis. The risk of venous thrombosis is some three- to sixfold higher than for patients admitted to a hospital for other indications, and for patients who have thrombosis, mortality appears to increase. Thrombosis m...
Conway, Susan R Keller, Michael D Bollard, Catherine M
Published in
Blood
Patients with blood disorders who are immune suppressed are at increased risk for infection with severe acute respiratory syndrome coronavirus 2. Sequelae of infection can include severe respiratory disease and/or prolonged duration of viral shedding. Cellular therapies may protect these vulnerable patients by providing antiviral cellular immunity ...
Flaumenhaft, Robert Enjyoji, Keiichi Schmaier, Alec A
Published in
Blood
COVID-19 is a primary respiratory illness that is frequently complicated by systemic involvement of the vasculature. Vascular involvement leads to an array of complications ranging from thrombosis to pulmonary edema secondary to loss of barrier function. This review will address the vasculopathy of COVID-19 with a focus on the role of the endotheli...
Langerbeins, Petra Hallek, Michael
Published in
Blood
The coronavirus infectious disease (COVID-19) shows a remarkable symptomatic heterogeneity. Several risk factors including advanced age, previous illnesses, and a compromised immune system contribute to an unfavorable outcome. In patients with hematologic malignancy, the immune response to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2...
Bissola, Anna-Lise Daka, Mercy Arnold, Donald M. Smith, James W. Moore, Jane C. Clare, Rumi Ivetic, Nikola Kelton, John G. Nazy, Ishac
Published in
Blood Advances
Vaccine-induced immune thrombotic thrombocytopenia (VITT) is a rare but serious adverse syndrome occurring 5 to 30 days after adenoviral vector COVID-19 vaccination. Therefore, a practical evaluation of clinical assessments and laboratory testing for VITT is needed to prevent significant adverse outcomes as the global use of adenoviral vector vacci...
Prasannan, Nithya Heightman, Melissa Hillman, Toby Wall, Emma Bell, Robert Kessler, Anna Neave, Lucy Doyle, Andrew Devaraj, Akshitha Singh, Deepak
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Published in
Blood Advances
Post-COVID syndrome (PCS), or long COVID, is an increasingly recognized complication of acute SARS-CoV-2 infection, characterized by persistent fatigue, reduced exercise tolerance, chest pain, shortness of breath, and cognitive slowing. Acute COVID-19 is strongly linked with an increased risk of thrombosis, which is a prothrombotic state quantified...
