Flynn, Ryan Paz, Katelyn Du, Jing Reichenbach, Dawn K Taylor, Patricia A Panoskaltsis-Mortari, Angela Vulic, Ante Luznik, Leo MacDonald, Kelli K P Hill, Geoffrey R
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Published in
Blood
Chronic graft-versus-host disease (cGVHD) remains a major complication following allogeneic bone marrow transplantation (BMT). The discovery of novel therapeutics is dependent on assessment in preclinical murine models of cGVHD. Rho-associated kinase 2 (ROCK2) recently was shown to be implicated in regulation of interleukin-21 (IL-21) and IL-17 sec...
Veenstra, Rachelle G Flynn, Ryan Kreymborg, Katharina McDonald-Hyman, Cameron Saha, Asim Taylor, Patricia A Osborn, Mark J Panoskaltsis-Mortari, Angela Schmitt-Graeff, Annette Lieberknect, Elisabeth
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Published in
Blood
Members of the B7 family have been shown to be important for regulating immune responses by providing either positive or negative costimulatory signals. The function of B7-H3 has been controversial. We show that B7-H3 is upregulated in graft-versus-host disease (GVHD) target organs, including the colon, liver, and lung. Infusion of allogeneic donor...
Pai, Chien-Chun Steven Chen, Mingyi Mirsoian, Annie Grossenbacher, Steven K Tellez, Joseph Ames, Erik Sun, Kai Jagdeo, Jared Blazar, Bruce R Murphy, William J
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Published in
Blood
Chronic graft-versus-host disease (cGVHD) following allogeneic hematopoietic stem cell transplantation (HSCT) has emerged as a predominant complication following HSCT and has a distinct etiology. We and others have previously demonstrated that bortezomib, a proteasome inhibitor, can prevent but not treat acute GVHD in mice. To assess the effects of...
Mraz, Marek Chen, Liguang Rassenti, Laura Z Ghia, Emanuela M Li, Hongying Jepsen, Kristen Smith, Erin N Messer, Karen Frazer, Kelly A Kipps, Thomas J
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Published in
Blood
We examined the microRNAs (miRNAs) expressed in chronic lymphocytic leukemia (CLL) and identified miR-150 as the most abundant, but with leukemia cell expression levels that varied among patients. CLL cells that expressed ζ-chain-associated protein of 70 kDa (ZAP-70) or that used unmutated immunoglobulin heavy chain variable (IGHV) genes, each had ...
Flynn, Ryan Du, Jing Veenstra, Rachelle G Reichenbach, Dawn K Panoskaltsis-Mortari, Angela Taylor, Patricia A Freeman, Gordon J Serody, Jonathan S Murphy, William J Munn, David H
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Published in
Blood
Chronic graft-versus-host disease (cGVHD) is a leading cause of morbidity and mortality after allogeneic hematopoietic stem cell transplantation. Having shown that germinal center (GC) formation and immunoglobulin deposition are required for multiorgan system cGVHD and associated bronchiolitis obliterans syndrome (BOS) in a murine model, we hypothe...
Klimenkova, Olga Ellerbeck, Wienke Klimiankou, Maksim Ünalan, Murat Kandabarau, Siarhei Gigina, Anna Hussein, Kais Zeidler, Cornelia Welte, Karl Skokowa, Julia
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Published in
Blood
We identified diminished levels of the natural inhibitor of neutrophil elastase (NE), secretory leukocyte protease inhibitor (SLPI), in myeloid cells and plasma of patients with severe congenital neutropenia (CN). We further found that downregulation of SLPI in CD34(+) bone marrow (BM) hematopoietic progenitors from healthy individuals resulted in ...
Published in
Blood
We conducted a genome-wide association study to identify novel associations between genetic variants and circulating plasminogen activator inhibitor-1 (PAI-1) concentration, and examined functional implications of variants and genes that were discovered. A discovery meta-analysis was performed in 19 599 subjects, followed by replication analysis of...
Gerrits, Alice Walasek, Marta A Olthof, Sandra Weersing, Ellen Ritsema, Martha Zwart, Erik van Os, Ronald Bystrykh, Leonid V de Haan, Gerald
Published in
Blood
Hematopoietic stem/progenitor cell (HSPC) traits differ between genetically distinct mouse strains. For example, DBA/2 mice have a higher HSPC frequency compared with C57BL/6 mice. We performed a genetic screen for micro-RNAs that are differentially expressed between LSK, LS(-)K(+), erythroid and myeloid cells isolated from C57BL/6 and DBA/2 mice. ...
Hur, Em Patel, Sn Shimizu, S Dinesh S. Rao Gnanapragasam, Pn An, Ds Yang, L Baltimore, D
Published in
Blood
Published in
Blood
Acquisition of homozygous activating growth factor receptor mutations might accelerate cancer progression through a simple gene-dosage effect. Internal tandem duplications (ITDs) of FLT3 occur in approximately 25% cases of acute myeloid leukemia and induce ligand-independent constitutive signaling. Homozygous FLT3-ITDs confer an adverse prognosis a...
