Single-cell ATAC-seq reveals GATA2-dependent priming defect in myeloid and a maturation bottleneck in lymphoid lineages
Published in Blood Advances
HIF2 keeps paces in tight hypoxic spaces
Published in Blood
In this issue of Blood , Sormendi et al provide compelling evidence that the stabilization of transcription factor hypoxia-inducible factor 2 (HIF2) promotes the motility of polymorphonuclear leukocytes (PMN), especially neutrophils, through highly constrained matrices. 1
ROR1 targeting with the antibody-drug conjugate VLS-101 is effective in Richter syndrome patient–derived xenograft mouse...
...Published in Blood
Associated guilt: radiation/bystanders
Published in Blood
Radiation-induced bystander effects (RIBEs) is a neglected, but crucial, area of radiation response. In this issued of Blood , Hu et al 1 have provided important new information and mechanistic insights into RIBE-impairment of hematopoietic stem (HSC) and progenitor (HPC) cells in hematopoietic cell transplantation (HCT), with implications for the ...
Primary resistance to CD19-directed chimeric antigen receptor T-cell therapy in T-cell/histiocyte-rich large B-cell lymp...
...Published in Blood
Cryo-EM structures of human coagulation factors V and Va
Published in Blood
EBF1 and PAX5 control pro-B cell expansion via opposing regulation of the Myc gene
...Published in Blood
Circulating mitochondrial DNA is a proinflammatory DAMP in sickle cell disease
...Published in Blood
Proof of concept for a rapidly switchable universal CAR-T platform with UniCAR-T-CD123 in relapsed/refractory AML
...Published in Blood
Targeting Bfl-1 via acute CDK9 inhibition overcomes intrinsic BH3 mimetic resistance in lymphomas.
...Published in Blood
BH3 mimetics like Venetoclax target pro-survival Bcl-2 family proteins and are important therapeutics in the treatment of hematological malignancies. We demonstrate endogenous Bfl-1 expression can render preclinical lymphoma tumor models insensitive to Mcl-1 and Bcl-2-inhibitors. However, suppression of Bfl-1 alone was insufficient to fully induce ...
