Erratum for Nahm et al., “A Common Food Glycan, Pectin, Shares an Antigen with Streptococcus pneumoniae Capsule”
Published in mSphere
Correction for Liu et al., “Draft Genome Sequence of Salipiger sp. Strain D13, a Phthalate Ester-Degrading Bacterium Iso...
Published in Microbiology Resource Announcements
Compounds with Therapeutic Potential against Novel Respiratory 2019 Coronavirus
Published in Antimicrobial Agents and Chemotherapy
Currently, the expansion of the novel human respiratory coronavirus (known as SARS-CoV-2 [severe acute respiratory syndrome coronavirus 2], COVID-2019 [coronavirus disease 2019], or 2019-nCoV [2019 novel coronavirus]) has stressed the need for therapeutic alternatives to alleviate and stop this new epidemic. The previous epidemics of infections by ...
Tilorone: A Broad-Spectrum Antiviral For Emerging Viruses.
Published in Antimicrobial agents and chemotherapy
Tilorone is a 50-year-old synthetic small-molecule compound with antiviral activity that is proposed to induce interferon after oral administration. This drug is used as a broad-spectrum antiviral in several countries of the Russian Federation. We have recently described activity in vitro and in vivo against the Ebola Virus. After a broad screening...
An Individual Participant Data Population Pharmacokinetic Meta-analysis of Drug-Drug Interactions between Lumefantrine a...
...Published in Antimicrobial Agents and Chemotherapy
Treating malaria in HIV-coinfected individuals should consider potential drug-drug interactions. Artemether-lumefantrine is the most widely recommended treatment for uncomplicated malaria globally. Lumefantrine is metabolized by CYP3A4, an enzyme that commonly used antiretrovirals often induce or inhibit. A population pharmacokinetic meta-analysis ...
Scope and Predictive Genetic/Phenotypic Signatures of Bicarbonate (NaHCO 3) Responsiveness and β-Lactam Sensitization in...
...Published in Antimicrobial Agents and Chemotherapy
Addition of sodium bicarbonate (NaHCO3) to standard antimicrobial susceptibility testing medium reveals certain methicillin-resistant Staphylococcus aureus (MRSA) strains to be highly susceptible to β-lactams. We investigated the prevalence of this phenotype (NaHCO3 responsiveness) to two β-lactams among 58 clinical MRSA bloodstream isolates. Of no...
Erratum for Teymournejad et al., “Isolation and Molecular Analysis of a Novel Neorickettsia Species That Causes Potomac ...
Published in mBio
Effects of Tenofovir on the Single-Dose Pharmacokinetics of Intravenous Morinidazole in Healthy Chinese Subjects
Published in Antimicrobial Agents and Chemotherapy
The effects of multiple-dose administration of tenofovir disoproxil fumarate (TDF) on the pharmacokinetics of morinidazole (MOR) were compared in healthy subjects. MOR exposure was similar, with an area under the curve from 0 h to infinity (AUC0-∞) treatment ratio for MOR+TDF/MOR of 1.01 (90% confidence interval, 0.97 to 1.06). No relevant differen...
Abacavir Exposure in Children Cotreated for Tuberculosis with Rifampin and Superboosted Lopinavir-Ritonavir
...Published in Antimicrobial Agents and Chemotherapy
In children requiring lopinavir coformulated with ritonavir in a 4:1 ratio (lopinavir-ritonavir-4:1) and rifampin, adding ritonavir to achieve a 4:4 ratio with lopinavir (LPV/r-4:4) overcomes the drug-drug interaction. Possible drug-drug interactions within this regimen may affect abacavir concentrations, but this has never been studied. Children w...
Tissue Distribution of Doxycycline in Animal Models of Tuberculosis
...Published in Antimicrobial Agents and Chemotherapy
Doxycycline, an FDA-approved tetracycline, is used in tuberculosis in vivo models for the temporal control of mycobacterial gene expression. In these models, animals are infected with recombinant Mycobacterium tuberculosis carrying genes of interest under transcriptional control of the doxycycline-responsive TetR- tetO unit. To minimize fluctuation...
