Townsley, Loni Sison Mangus, Marilou P Mehic, Sanjin Yildiz, Fitnat H
Published in
Applied and environmental microbiology
Little is known about how human pathogens respond and adapt to ever-changing parameters of natural habitats outside the human host and how environmental adaptation alters dissemination. Vibrio cholerae, the causative agent of the severe diarrheal disease cholera, experiences fluctuations in temperature in its natural aquatic habitats and during the...
Collins, Kieran D Andermann, Tessa M Draper, Jenny Sanders, Lisa Williams, Susan M Araghi, Cameron Ottemann, Karen M
Published in
Journal of bacteriology
Helicobacter pylori senses its environment with proteins called chemoreceptors. Chemoreceptors integrate this sensory information to affect flagellum-based motility in a process called chemotaxis. Chemotaxis is employed during infection and presumably aids H. pylori in encountering and colonizing preferred niches. A cytoplasmic chemoreceptor named ...
Park, Ah-Mee Hagiwara, Satoru Hsu, Daniel K Liu, Fu-Tong Yoshie, Osamu
Published in
Infection and immunity
We studied the role of galectin-3 (Gal3) in gastric infection by Helicobacter pylori We first demonstrated that Gal3 was selectively expressed by gastric surface epithelial cells and abundantly secreted into the surface mucus layer. We next inoculated H. pylori Sydney strain 1 into wild-type (WT) and Gal3-deficient mice using a stomach tube. At 2 w...
Conner, Jenna G Teschler, Jennifer K Jones, Christopher J Yildiz, Fitnat H
Published in
Microbiology spectrum
Infectious diseases kill nearly 9 million people annually. Bacterial pathogens are responsible for a large proportion of these diseases, and the bacterial agents of pneumonia, diarrhea, and tuberculosis are leading causes of death and disability worldwide. Increasingly, the crucial role of nonhost environments in the life cycle of bacterial pathoge...
Michael Bear
Published in
Journal of Microbiology and Biology Education
Citizen science can be defined as the process by which any non-scientist collects data or uses the scientific method under the guidance or mentorship of a scientist. This article presents an overview of several marine citizen-science projects as practiced by three non-profit organizations.
Michael Bear
Published in
Journal of Microbiology and Biology Education
Citizen science can be defined as the process by which any non-scientist collects data or uses the scientific method under the guidance or mentorship of a scientist. This article presents an overview of several marine citizen-science projects as practiced by three non-profit organizations.
Franco, Magdalena Panas, Michael W Marino, Nicole D Lee, Mei-Chong Wendy Buchholz, Kerry R Kelly, Felice D Bednarski, Jeffrey J Sleckman, Barry P Pourmand, Nader Boothroyd, John C
...
Published in
mBio
The intracellular protozoan Toxoplasma gondii dramatically reprograms the transcriptome of host cells it infects, including substantially up-regulating the host oncogene c-myc. By applying a flow cytometry-based selection to infected mouse cells expressing green fluorescent protein fused to c-Myc (c-Myc-GFP), we isolated mutant tachyzoites defectiv...
Koo, Hyunmin Strope, Bailey M Kim, Eddy H Shabani, Adel M Kumar, Ranjit Crowley, Michael R Andersen, Dale T Bej, Asim K
Published in
Genome announcements
Janthinobacterium sp. Ant5-2-1, isolated from the Schirmacher Oasis of East Antarctica, produces a purple-violet pigment, manifests diverse energy metabolism abilities, and tolerates cold, ultraviolet radiation, and other environmental stressors. We report here the 6.19-Mb draft genome of strain Ant5-2-1, which will help understand its survival mec...
Rogers, Andrew Townsley, Loni Gallego-Hernandez, Ana L Beyhan, Sinem Kwuan, Laura Yildiz, Fitnat H
Published in
Journal of bacteriology
Bacteria utilize intracellular proteases to degrade damaged proteins and adapt to changing environments. The Lon protease has been shown to be important for environmental adaptation and plays a crucial role in regulating the motility, biofilm formation, and virulence of numerous plant and animal pathogens. We find that LonA of the human pathogen V....
Higginbotham, Jennifer M O'Shea, Clodagh C
Published in
Journal of virology
SUMO is a key posttranslational modification that modulates the function, localization, and assembly of protein complexes. In the ever-escalating host-pathogen arms race, viruses have evolved strategies to subvert sumoylation. Adenovirus is a small DNA tumor virus that is a global human pathogen and key biomedical agent in basic research and therap...
