Núñez-Otero, Carlos Bahnan, Wael Vielfort, Katarina Silver, Jim Singh, Pardeep Elbir, Haitham Almqvist, Fredrik Bergström, Sven Gylfe, Åsa
Published in
Antimicrobial agents and chemotherapy
Chlamydia trachomatis is a strict intracellular bacterium that causes sexually transmitted infections and eye infections that can lead to life-long sequelae. Treatment options are limited to broad-spectrum antibiotics that disturb the commensal flora and contribute to selection of antibiotic-resistant bacteria. Hence, development of novel drugs tha...
Rinaldi, Matteo Cojutti, Pier Giorgio Zamparini, Eleonora Tedeschi, Sara Rossi, Nicolò Conti, Matteo Giannella, Maddalena Pea, Federico Viale, Pierluigi
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Antimicrobial agents and chemotherapy
Background: Fosfomycin is gaining interest in the treatment of complex osteoarticular infections (OI) due to MDR pathogens.Objective: The aims were to conduct population pharmacokinetics of fosfomycin in a cohort of OI patients receiving 16g/daily by intermittent (II) or continuous infusion (CI), and to carry out Monte Carlo simulations for dosage ...
Chan, Chin-Fung Liu, Zhen Wong, Iris L K Zhao, Xianliang Yang, Zaofeng Zheng, Jiale Lee, Marianne M Chan, Michael K Chan, Tak Hang Chow, Larry M C
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Published in
Antimicrobial agents and chemotherapy
We have designed, synthesized, and characterized a library of 38 novel flavonoid compounds linked with amines. Some of these amine-linked flavonoids have potent in vitro activity against parasites that cause cutaneous leishmaniasis, a tropical disease endemic in 80 countries worldwide. The most promising candidate, FM09h, was highly active with IC5...
Pantel, Lucile Juarez, Paulo Serri, Marine Boucinha, Lilia Lessoud, Emilie Lanois, Anne Givaudan, Alain Racine, Emilie Gualtieri, Maxime
Published in
Antimicrobial agents and chemotherapy
NOSO-502 is a preclinical antibiotic candidate of the Odilorhabdin class. This compound exhibits activity against Enterobacteriaceae pathogens, including carbapenemase-producing bacteria and most of the Colistin (CST)-resistant strains. Among a collection of CST-resistant Klebsiella pneumoniae strains harboring mutations on genes pmrAB, mgrB, phoPQ...
Huang, Huiping Xie, Helin Chaphekar, Nupur Xu, Ruichao Venkataramanan, Raman Wu, Xuemei
Published in
Antimicrobial agents and chemotherapy
Isavuconazole (ISA) is an azole antifungal used in the treatment of invasive aspergillosis and mucormycosis. Patients with mild and moderate hepatic impairment have lower clearance (CL) as compared to the healthy population. Currently, there is no data on ISA in patients with severe hepatic impairment (Child-Pugh Class C). The purpose of this study...
Valcek, Adam Sismova, Petra Nesporova, Kristina Overballe-Petersen, Søren Bitar, Ibrahim Jamborova, Ivana Kant, Arie Hrabak, Jaroslav Wagenaar, Jaap A Madec, Jean-Yves
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Published in
Antimicrobial agents and chemotherapy
The relatedness of the equine-associated Escherichia coli ST1250 and its single- and double-locus variants (ST1250-SLV/DLV), obtained from horses in Europe, was studied by comparative genome analysis. A total of 54 isolates of E. coli ST1250 and ST1250-SLV/DLV from healthy and hospitalized horses across Europe [Czech Republic (n=23), the Netherland...
Omollo, Charles Singh, Vinayak Kigondu, Elizabeth Wasuna, Antonina Agarwal, Pooja Moosa, Atica Ioerger, Thomas R Mizrahi, Valerie Chibale, Kelly Warner, Digby F
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Published in
Antimicrobial agents and chemotherapy
Tuberculosis (TB) is a leading global cause of mortality owing to an infectious agent, accounting for almost one-third of antimicrobial resistance (AMR) deaths annually. We aimed to identify synergistic anti-TB drug combinations with the capacity to restore therapeutic efficacy against drug-resistant mutants of the causative agent, Mycobacterium tu...
Srivastava, Shashikant Wang, Jann-Yuan Magombedze, Gesham Chapagain, Moti Huang, Hung-Ling Deshpande, Devyani Heysell, Scott K Pasipanodya, Jotam G Gumbo, Tawanda
Published in
Antimicrobial agents and chemotherapy
Standard therapy [isoniazid, rifampin, ethambutol], with or without a macrolide, for pulmonary Mycobacterium kansasii lasts more than a year. Therefore, shorter treatment duration regimens are required. We used data from 32 Taiwanese patients treated with standard therapy who were followed using repetitive sampling-based sputum Mkn time-to-positivi...
Su, Huilin Zhu, Min Tsui, Clement Kin-Ming van der Lee, Henrich Tehupeiory-Kooreman, Marlou Zoll, Jan Engel, Tobias Li, Li Zhu, Junhao Lu, Zihan
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Published in
Antimicrobial agents and chemotherapy
Triazole resistance in A. fumigatus is an increasing worldwide problem that causes major challenges in the management of aspergillosis. New antifungal drugs are needed with novel targets, that are effective in triazole-resistant infection. In this study, we retrospectively evaluated potency of the novel drug olorofim compared to contemporary antifu...
Griffith, David C Morgan, Elizabeth E Dudley, Michael N Loutit, Jeffery S
Published in
Antimicrobial agents and chemotherapy
The pharmacokinetics and safety of biapenem were studied in 36 healthy adult subjects in a randomized, placebo-controlled, double blind, sequential single and multiple-ascending dose study using doses from 250 to 1250 mg administered three times a day using 3-hour infusions. Maximum concentrations for biapenem were achieved at the end of the 3-hour...
