Lu, Jinghua Sun, Peter D.
Published in
The Journal of Biological Chemistry
The novel severe acute respiratory syndrome coronavirus (SARS-CoV-2) has emerged to a pandemic and caused global public health crisis. Human angiotensin-converting enzyme 2(ACE2) was identified as the entry receptor for SARS-CoV-2. As a carboxypeptidase, ACE2 cleaves many biological substrates besides angiotensin II to control vasodilatation and va...
Ghosh, Sonali Basu, Moitri Roy, Sib Sankar
Published in
The Journal of Biological Chemistry
Safdar, Adeel Little, Jonathan P. Stokl, Andrew J. Hettinga, Bart P. Akhtar, Mahmood Tarnopolsky, Mark A.
Published in
The Journal of Biological Chemistry
Usher, Emery T. Showalter, Scott A.
Published in
The Journal of Biological Chemistry
Defining discontinuous antigenic epitopes remains a substantial challenge, as exemplified by the case of lipid transfer polyproteins, which are common pollen allergens. Hydrogen/deuterium exchange monitored by NMR can be used to map epitopes onto folded protein surfaces, but only if the complex rapidly dissociates. Modifying the standard NMR-exchan...
Prole, David L. Chinnery, Patrick F. Jones, Nick S.
Published in
The Journal of Biological Chemistry
Mitochondrial DNA (mtDNA) encodes proteins and RNAs that support the functions of mitochondria and thereby numerous physiological processes. Mutations of mtDNA can cause mitochondrial diseases and are implicated in aging. The mtDNA within cells is organized into nucleoids within the mitochondrial matrix, but how mtDNA nucleoids are formed and regul...
Kaludercic, Nina Di Lisa, Fabio
Published in
The Journal of Biological Chemistry
Under conditions of high nutrient availability and low ATP synthesis, mitochondria generate reactive oxygen species (ROS) that must be removed to avoid cell injury. Among the enzymes involved in this scavenging process, peroxidases play a crucial role, using NADPH provided mostly by nicotinamide nucleotide transhydrogenase (NNT). However, scarce in...
Wu, Xiaoyun Schnitzler, Gavin R. Gao, Galen F. Diamond, Brett Baker, Andrew R. Kaplan, Bethany Williamson, Kaylyn Westlake, Lindsay Lorrey, Selena Lewis, Timothy A.
...
Published in
The Journal of Biological Chemistry
Tian, Jing Ok Lee, Soo Liang, Liang Luo, Jie Huang, Chiung-Kuei Li, Lei Niu, Yuanjie Chang, Chawnshang
Published in
The Journal of Biological Chemistry
Kang, Ting Lu, Wan Xu, Wei Anderson, Leonard Bacanamwo, Methode Thompson, Winston Chen, Y. Eugene Liu, Dong
Published in
The Journal of Biological Chemistry
Fischle, Wolfgang
Published in
The Journal of Biological Chemistry
ChIP-Seq is a widespread experimental method for determining the global enrichment of chromatin modifications and genome-associated factors. Whereas it is straightforward to compare the relative genomic distribution of these epigenetic features, researchers have also made efforts to compare their signal strength using external references for normal...