Mishra, Vishwas Sharma, Kritica Bose, Avipsa Maisonneuve, Pierre Visweswariah, Sandhya S.
Published in
The Journal of Biological Chemistry
Mutations in receptor guanylyl cyclase C (GC-C) cause severe gastrointestinal disease, including meconium ileus, early onset acute diarrhea, and pediatric inflammatory bowel disease that continues into adulthood. Agonists of GC-C are US Food and Drug Administration-approved drugs for the treatment of constipation and irritable bowel syndrome. Thera...
Collet, Jean-François Cho, Seung-Hyun Iorga, Bogdan I Goemans, Camille V
Published in
The Journal of biological chemistry
The cell envelope of Gram-negative bacteria is a multilayered structure essential for bacterial viability; the peptidoglycan cell wall provides shape and osmotic protection to the cell, and the outer membrane serves as a permeability barrier against noxious compounds in the external environment. Assembling the envelope properly and maintaining its ...
Martoriati, Alain Molinaro, Caroline Marchand, Guillaume Fliniaux, Ingrid Marin, Matthieu Bodart, Jean-François Takeda-Uchimura, Yoshiko Lefebvre, Tony Dehennaut, Vanessa Cailliau, Katia
...
Published in
The Journal of Biological Chemistry
Xenopus oocytes are encompassed by a layer of follicular cells that contribute to oocyte growth and meiosis in relation to oocyte maturation. However, the effects of the interaction between follicular cells and the oocyte surface on meiotic processes are unclear. Here, we investigated Xenopus follicular cell function using oocyte signaling and hete...
Hediyeh-Zadeh, Soroor Webb, Andrew I Davis, Melissa J
Published in
Molecular & cellular proteomics : MCP
Mass spectrometry (MS) enables high-throughput identification and quantification of proteins in complex biological samples and can provide insights into the global function of biological systems. Label-free quantification is cost-effective and suitable for the analysis of human samples. Despite rapid developments in label-free data acquisition work...
McNamar, Rachel Freeman, Emma Baylor, Kairo N Fakhouri, Aula M Huang, Sui Knutson, Bruce A Rothblum, Lawrence I
Published in
The Journal of biological chemistry
The application of genetic and biochemical techniques in yeast has informed our knowledge of transcription in mammalian cells. Such systems have allowed investigators to determine whether a gene was essential and to determine its function in rDNA transcription. However, there are significant differences in the nature of the transcription factors es...
Lim, JiaWen Lilie, Hauke Kalbacher, Hubert Roos, Nora Frecot, Desiree Isabella Feige, Maximilian Conrady, Marcel Votteler, Tobias Cousido-Siah, Alexandra Bartoli, Giada Corradini
...
Published in
The Journal of Biological Chemistry
Human papillomaviruses (HPVs) are DNA tumor viruses that infect mucosal and cutaneous epithelial cells of more than 20 vertebrates. High-risk HPV causes about 5% of human cancers worldwide, and the viral proteins E6 and E7 promote carcinogenesis by interacting with tumor suppressors and interfering with many cellular pathways. As a consequence, the...
Zhang, Jie Ye, Zhi-Wei Bräutigam, Lars Chakraborty, Paramita Luo, Zhenwu Culpepper, John Aslam, Muhammad Zhang, Leilei Johansson, Katarina Haeggström, Jesper Z
...
Published in
The Journal of biological chemistry
Recent advancements in the treatment of melanoma are encouraging, but there remains a need to identify additional therapeutic targets. We identify a role for microsomal glutathione transferase 1 (MGST1) in biosynthetic pathways for melanin and as a determinant of tumor progression. Knockdown (KD) of MGST1 depleted midline-localized, pigmented melan...
Ridlon, Jason M Daniel, Steven L Gaskins, H Rex
Published in
Journal of lipid research
Bile acids are detergents derived from cholesterol that function to solubilize dietary lipids, remove cholesterol from the body, and act as nutrient signaling molecules in numerous tissues with functions in the liver and gut being the best understood. Studies in the early 20th century established the structures of bile acids, and by mid-century, th...
Chandra Shekhar, Arvind Wu, Wen-Jin Chen, Hung-Ta
Published in
The Journal of Biological Chemistry
Duxbury, Mark S Ito, Hiromichi Ashley, Stanley W Whang, Edward E
Published in
The Journal of biological chemistry
