Liu, Guiming Elrashidy, Rania A Xiao, Nan Kavran, Michael Huang, Yexiang Tao, Mingfang Powell, C Thomas Kim, Edward Sadeghi, Ghazal Mohamed, Hoda E
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Published in
AJP Cell Physiology
Manganese superoxide dismutase (MnSOD) is considered a critical component of the antioxidant systems that protect against oxidative damage. We are interested in the role of oxidative stress in bladder detrusor smooth muscle (SM) in different disease states. In this study, we generated an inducible, SM-specific Sod2(-/-) mouse model to investigate t...
Chen, Shu Okahara, Fumiaki Osaki, Noriko Shimotoyodome, Akira
Published in
AJP Endocrinology and Metabolism
Glucose-dependent insulinotropic polypeptide (GIP) is a gut hormone secreted in response to dietary fat and glucose. The blood GIP level is elevated in obesity and diabetes. GIP stimulates proinflammatory gene expression and impairs insulin sensitivity in cultured adipocytes. In obesity, hypoxia within adipose tissue can induce inflammation. The ai...
Published in
Journal of Neurophysiology
Humans use their arms to engage in a wide variety of motor tasks during everyday life. However, little is known about the statistics of these natural arm movements. Studies of the sensory system have shown that the statistics of sensory inputs are key to determining sensory processing. We hypothesized that the statistics of natural everyday movemen...
Published in
AJP Lung Cellular and Molecular Physiology
The epithelial sodium channel (ENaC) is responsible for Na(+) and fluid absorption across colon, kidney, and airway epithelia. Short palate lung and nasal epithelial clone 1 (SPLUNC1) is a secreted, innate defense protein and an autocrine inhibitor of ENaC that is highly expressed in airway epithelia. While SPLUNC1 has a bactericidal permeability-i...
Xu, Cheng Li, Xuezheng Wang, Fang Weng, Hongbo Yang, Peixin
Published in
AJP Endocrinology and Metabolism
Preexisting maternal diabetes increases the risk of neural tube defects (NTDs). The mechanism underlying maternal diabetes-induced NTDs is not totally defined, and its prevention remains a challenge. Autophagy, an intracellular process to degrade dysfunction protein and damaged cellular organelles, regulates cell proliferation, differentiation, and...
Published in
AJP Heart and Circulatory Physiology
We investigated whether plasma long-chain sphingoid base (LCSB) concentrations are altered by transient cardiac ischemia during percutaneous coronary intervention (PCI) in humans and examined the signaling through the sphingosine-1-phosphate (S1P) cascade as a mechanism underlying the S1P cardioprotective effect in cardiac myocytes. Venous samples ...
Published in
AJP Endocrinology and Metabolism
Pseudohypoaldosteronism type 1 (PHA1) is a monogenic disorder of mineralocorticoid resistance characterized by salt wasting, hyperkalemia, high aldosterone levels, and failure to thrive. An autosomal recessive form (AR-PHA1) is caused by mutations in the epithelial sodium channel ENaC with usually severe and persisting multiorgan symptoms. The auto...
Li, Huika Landers, Kelly Patel, Jatin Richard, Kerry Mortimer, Robin H
Published in
AJP Endocrinology and Metabolism
Normal human fetal development requires an adequate supply of thyroid hormone from conception. Until about 16 wk gestation this is supplied entirely by placental transfer of maternal hormone. Subsequently, the fetal thyroid synthesizes thyroid hormones, requiring a supply of maternal iodide. Trophoblast iodide transfer is mediated by the apical sod...
Sow, Fatoumata B Gallup, Jack M Olivier, Alicia Krishnan, Subramaniam Patera, Andriani C Suzich, JoAnn Ackermann, Mark R
Published in
AJP Lung Cellular and Molecular Physiology
Respiratory syncytial virus (RSV) is the leading cause of lower respiratory tract infection in children worldwide. The understanding of neonatal RSV pathogenesis depends on using an animal model that reproduces neonatal RSV disease. Previous studies from us and others demonstrated that the neonatal lamb model resembles human neonatal RSV infection....
Tantiwong, Puntip Shanmugasundaram, Karthigayan Monroy, Adriana Ghosh, Sangeeta Li, Mengyao DeFronzo, Ralph A Cersosimo, Eugenio Sriwijitkamol, Apiradee Mohan, Sumathy Musi, Nicolas
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Published in
AJP Endocrinology and Metabolism
NF-κB is a transcription factor that controls the gene expression of several proinflammatory proteins. Cell culture and animal studies have implicated increased NF-κB activity in the pathogenesis of insulin resistance and muscle atrophy. However, it is unclear whether insulin-resistant human subjects have abnormal NF-κB activity in muscle. The effe...
