Grossman, Daniel Raifman, Sarah Morris, Natalie Arena, Andrea Bachrach, Lela Beaman, Jessica Biggs, M Antonia Collins, Amy Hannum, Curtiss Ho, Stephanie
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Published in
JAMA internal medicine
Before 2021, the US Food and Drug Administration required mifepristone to be dispensed in person, limiting access to medication abortion. To estimate the effectiveness, acceptability, and feasibility of dispensing mifepristone for medication abortion using a mail-order pharmacy. This prospective cohort study was conducted from January 2020 to May 2...
Rigotti, Nancy A Benowitz, Neal L Prochaska, Judith J Cain, Daniel F Ball, Julie Clarke, Anthony Blumenstein, Brent A Jacobs, Cindy
Published in
JAMA internal medicine
The prevalence of e-cigarette use among US adults, especially young adults, is rising. Many would like to quit vaping nicotine but are unable to do so. Cytisinicline, a plant-based alkaloid, targets nicotinic acetylcholine receptors, reduces nicotine dependence, and helps adults to stop smoking cigarettes. Cytisinicline may also help e-cigarette us...
Kaul, Inder Sawchak, Sharon Walling, David P Tamminga, Carol A Breier, Alan Zhu, Haiyuan Miller, Andrew C Paul, Steven M Brannan, Stephen K
Published in
JAMA psychiatry
A significant need exists for new antipsychotic medications with different mechanisms of action, greater efficacy, and better tolerability than existing agents. Xanomeline is a dual M1/M4 preferring muscarinic receptor agonist with no direct D2 dopamine receptor blocking activity. KarXT combines xanomeline with the peripheral muscarinic receptor an...
Hoddinott, Pat O'Dolan, Catriona Macaulay, Lisa Dombrowski, Stephan U Swingler, James Cotton, Seonaidh Avenell, Alison Getaneh, Abraham M Gray, Cindy Hunt, Kate
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Published in
JAMA
Effective weight loss interventions are needed for men with obesity. To determine whether an intervention that combined text messaging with financial incentives attained significant weight loss at the 12-month follow-up compared with the control group and whether an intervention of text messaging alone attained significant weight loss at the 12-mon...
Spring, Bonnie Pfammatter, Angela F Scanlan, Laura Daly, Elyse Reading, Jean Battalio, Sam McFadden, H Gene Hedeker, Don Siddique, Juned Nahum-Shani, Inbal
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Published in
JAMA
Lifestyle interventions for weight loss are difficult to implement in clinical practice. Self-managed mobile health implementations without or with added support after unsuccessful weight loss attempts could offer effective population-level obesity management. To test whether a wireless feedback system (WFS) yields noninferior weight loss vs WFS pl...
Yoo, Nina Mun, Ji Yeon Kye, Bong-Hyeon Kim, Chang Woo Lee, Jae Im Park, Youn Young Kang, Byung Mo Park, Byung Kwan Kwak, Han Deok Kang, Won-Kyung
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Published in
JAMA surgery
Surgical site infections (SSIs) are prevalent hospital-acquired infections with significant patient impacts and global health care burdens. The World Health Organization recommends using wound protector devices in abdominal surgery as a preventive measure to lower the risk of SSIs despite limited evidence. To examine the efficacy of a dual-ring, pl...
Neumann, Johannes Tobias Twerenbold, Raphael Weimann, Jessica Ballantyne, Christie M Benjamin, Emelia J Costanzo, Simona de Lemos, James A deFilippi, Christopher R Di Castelnuovo, Augusto Donfrancesco, Chiara
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Published in
JAMA
Identification of individuals at high risk for atherosclerotic cardiovascular disease within the population is important to inform primary prevention strategies. To evaluate the prognostic value of routinely available cardiovascular biomarkers when added to established risk factors. Individual-level analysis including data on cardiovascular biomark...
Feng, Xiaoshuang Zahed, Hana Onwuka, Justina Callister, Matthew E J Johansson, Mattias Etzioni, Ruth Robbins, Hilary A
Published in
JAMA
Randomized clinical trials of cancer screening typically use cancer-specific mortality as the primary end point. The incidence of stage III-IV cancer is a potential alternative end point that may accelerate completion of randomized clinical trials of cancer screening. To compare cancer-specific mortality with stage III-IV cancer as end points in ra...
Selvaraj, Senthil Claggett, Brian Shah, Svati H Mentz, Robert J Khouri, Michel G Manichaikul, Ani W Khan, Sadiya S Rich, Stephen S Mosley, Thomas H Levitan, Emily B
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Published in
JAMA
Individual cohort studies concur that the amyloidogenic V142I variant of the transthyretin (TTR) gene, present in 3% to 4% of US Black individuals, increases heart failure (HF) and mortality risk. Precisely defining carrier risk across relevant clinical outcomes and estimating population burden of disease are important given established and emergin...
Peikert, Alexander Claggett, Brian L Udell, Jacob A Joseph, Jacob Hegde, Sheila M Kim, KyungMann Mao, Lu Wang, Tuo Havighurst, Thomas C Farkouh, Michael E
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Published in
JAMA cardiology
High-dose trivalent compared with standard-dose quadrivalent influenza vaccine did not significantly reduce all-cause mortality or cardiopulmonary hospitalizations in patients with high-risk cardiovascular disease in the INVESTED trial. Whether humoral immune response to influenza vaccine is associated with clinical outcomes is unknown. To examine ...