Nature's treasure hunt
Published in Science
The Atmosphere of Pluto as Observed by New Horizons
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Observations made during the New Horizons flyby provide a detailed snapshot of the current state of Pluto's atmosphere. While the lower atmosphere (at altitudes
Political priorities
Published in Science
A large scale screen reveals genes that mediate electrotaxis in Dictyostelium discoideum
...Published in Science Signaling
Engineering as a New Frontier for Translational Medicine
Published in Science Translational Medicine
Three crocodilian genomes reveal ancestral patterns of evolution among archosaurs.
...Published in Science (New York, N.Y.)
To provide context for the diversification of archosaurs--the group that includes crocodilians, dinosaurs, and birds--we generated draft genomes of three crocodilians: Alligator mississippiensis (the American alligator), Crocodylus porosus (the saltwater crocodile), and Gavialis gangeticus (the Indian gharial). We observed an exceptionally slow rat...
Fauna in decline: the community way.
Published in Science
Gene repression. H3K27me and PRC2 transmit a memory of repression across generations and during development.
Published in Science (New York, N.Y.)
For proper development, cells must retain patterns of gene expression and repression through cell division. Repression via methylation of histone H3 on Lys27 (H3K27me) by Polycomb repressive complex 2 (PRC2) is conserved, but its transmission is not well understood. Our studies suggest that PRC2 represses the X chromosomes in Caenorhabditis elegans...
Intestinal inhibition of the Na+/H+ exchanger 3 prevents cardiorenal damage in rats and inhibits Na+ uptake in humans.
...Published in Science Translational Medicine
The management of sodium intake is clinically important in many disease states including heart failure, kidney disease, and hypertension. Tenapanor is an inhibitor of the sodium-proton (Na(+)/H(+)) exchanger NHE3, which plays a prominent role in sodium handling in the gastrointestinal tract and kidney. When administered orally to rats, tenapanor ac...
Altered Histone Acetylation Is Associated with Age-Dependent Memory Impairment in Mice
Published in Science
As the human life span increases, the number of people suffering from cognitive decline is rising dramatically. The mechanisms underlying age-associated memory impairment are, however, not understood. Here we show that memory disturbances in the aging brain of the mouse are associated with altered hippocampal chromatin plasticity. During learning, ...
