Invest long term in Canada's wilderness
Published in Science
Nature's treasure hunt
Published in Science
Political priorities
Published in Science
Neuropilin-1 and heparan sulfate proteoglycans cooperate in cellular uptake of nanoparticles functionalized by cationic ...
Published in Science advances
Cell-penetrating peptides (CPPs) have been widely used to deliver nanomaterials and other types of macromolecules into mammalian cells for therapeutic and diagnostic use. Cationic CPPs that bind to heparan sulfate (HS) proteoglycans on the cell surface induce potent endocytosis; however, the role of other surface receptors in this process is unclea...
Engineering as a New Frontier for Translational Medicine
Published in Science Translational Medicine
A large scale screen reveals genes that mediate electrotaxis in Dictyostelium discoideum
...Published in Science Signaling
Whole-genome analyses resolve early branches in the tree of life of modern birds.
...Published in Science (New York, N.Y.)
To better determine the history of modern birds, we performed a genome-scale phylogenetic analysis of 48 species representing all orders of Neoaves using phylogenomic methods created to handle genome-scale data. We recovered a highly resolved tree that confirms previously controversial sister or close relationships. We identified the first divergen...
Three crocodilian genomes reveal ancestral patterns of evolution among archosaurs.
...Published in Science (New York, N.Y.)
To provide context for the diversification of archosaurs--the group that includes crocodilians, dinosaurs, and birds--we generated draft genomes of three crocodilians: Alligator mississippiensis (the American alligator), Crocodylus porosus (the saltwater crocodile), and Gavialis gangeticus (the Indian gharial). We observed an exceptionally slow rat...
Fauna in decline: the community way.
Published in Science
Gene repression. H3K27me and PRC2 transmit a memory of repression across generations and during development.
Published in Science (New York, N.Y.)
For proper development, cells must retain patterns of gene expression and repression through cell division. Repression via methylation of histone H3 on Lys27 (H3K27me) by Polycomb repressive complex 2 (PRC2) is conserved, but its transmission is not well understood. Our studies suggest that PRC2 represses the X chromosomes in Caenorhabditis elegans...
