Discovery of a hypersaline subglacial lake complex beneath Devon Ice Cap, Canadian Arctic
Published in Science Advances
Invest long term in Canada's wilderness
Published in Science
Functional odor classification through a medicinal chemistry approach
Published in Science Advances
Crucial for any hypothesis about odor coding is the classification and prediction of sensory qualities in chemical compounds. The relationship between perceptual quality and molecular structure has occupied olfactory scientists throughout the 20th century, but details of the mechanism remain elusive. Odor molecules are typically organic compounds o...
Nature's treasure hunt
Published in Science
The atmosphere of Pluto as observed by New Horizons
...Published in Science
In July 2015, the New Horizons spacecraft flew through the Pluto system at high speed, humanity's first close look at this enigmatic system on the outskirts of our solar system. In a series of papers, the New Horizons team present their analysis of the encounter data downloaded so far: Moore et al. present the complex surface features and geology o...
Bidirectional radial Ca(2+) activity regulates neurogenesis and migration during early cortical column formation.
Published in Science advances
Cortical columns are basic cellular and functional units of the cerebral cortex that are malformed in many brain disorders, but how they initially develop is not well understood. Using an optogenetic sensor in the mouse embryonic forebrain, we demonstrate that Ca(2+) fluxes propagate bidirectionally within the elongated fibers of radial glial cells...
Political priorities
Published in Science
In October, we asked young scientists how political priorities affect their ability to do and communicate science. We received a range of answers, some frustrated by political interference, others optimistic about the ability of political attention to effect change. Although many submissions focused on pleas for more science funding, we have focuse...
Neuropilin-1 and heparan sulfate proteoglycans cooperate in cellular uptake of nanoparticles functionalized by cationic ...
Published in Science advances
Cell-penetrating peptides (CPPs) have been widely used to deliver nanomaterials and other types of macromolecules into mammalian cells for therapeutic and diagnostic use. Cationic CPPs that bind to heparan sulfate (HS) proteoglycans on the cell surface induce potent endocytosis; however, the role of other surface receptors in this process is unclea...
IMMUNODEFICIENCIES. Impairment of immunity to Candida and Mycobacterium in humans with bi-allelic RORC mutations.
...Published in Science
Human inborn errors of immunity mediated by the cytokines interleukin-17A and interleukin-17F (IL-17A/F) underlie mucocutaneous candidiasis, whereas inborn errors of interferon-γ (IFN-γ) immunity underlie mycobacterial disease. We report the discovery of bi-allelic RORC loss-of-function mutations in seven individuals from three kindreds of differen...
Pim kinases modulate resistance to FLT3 tyrosine kinase inhibitors in FLT3-ITD acute myeloid leukemia
...Published in Science Advances
Fms-like tyrosine kinase 3 internal tandem duplication (FLT3-ITD) is frequently detected in acute myeloid leukemia (AML) patients and is associated with a dismal long-term prognosis. FLT3 tyrosine kinase inhibitors provide short-term disease control, but relapse invariably occurs within months. Pim protein kinases are oncogenic FLT3-ITD targets exp...
