Melatonin enhances sorafenib actions in human hepatocarcinoma cells by inhibiting mTORC1/p70S6K/HIF-1α and hypoxia-media...
Published in Oncotarget
Multiple spatially related pharmacophores define small molecule inhibitors of OLIG2 in glioblastoma.
...Published in Oncotarget
Transcription factors (TFs) are a major class of protein signaling molecules that play key cellular roles in cancers such as the highly lethal brain cancer-glioblastoma (GBM). However, the development of specific TF inhibitors has proved difficult owing to expansive protein-protein interfaces and the absence of hydrophobic pockets. We uniquely defi...
EZH2 inhibition suppresses endometrial cancer progression via miR-361/Twist axis
...Published in Oncotarget
Impact of resistance training on the autophagy-inflammation-apoptosis crosstalk in elderly subjects
Published in Aging
PD-1 mediates functional exhaustion of activated NK cells in patients with Kaposi sarcoma
...Published in Oncotarget
Programmed Death-1 (PD-1), an inhibitory receptor expressed by activated lymphocytes, is involved in regulating T- and B-cell responses. PD-1 and its ligands are exploited by a variety of cancers to facilitate tumor escape through PD-1-mediated functional exhaustion of effector T cells. Here, we report that PD-1 is upregulated on Natural Killer (NK...
Radio-frequency plasma polymerized biodegradable carrier for in vivo release of cis-platinum
Published in Oncotarget
A low pressure plasma process based on plasma deposition has been used todevelop a drug delivery strategy. In this study, a drug delivery system based ondifferent layers of plasma co-polymerized Poly ε-caprolactone-Polyethylene glycol(PCL-PEG) co-polymers was deposited on biocompatible substrates. Cis-platinum(118 μgm/cm2) was used as an anti-cance...
SRC Kinase Inhibition with Saracatinib Limits the Development of Osteolytic Bone Disease in Multiple Myeloma
...Published in Oncotarget
Multiple myeloma (MM)-associated osteolytic bone disease is a major cause of morbidity and mortality in MM patients and the development of new therapeutic strategies is of great interest. The proto-oncogene SRC is an attractive target for such a strategy. In the current study, we investigated the effect of treatment with the SRC inhibitor saracatin...
Targeting of short TRPM8 isoforms induces 4TM-TRPM8-dependent apoptosis in prostate cancer cells.
...Published in Oncotarget
Since its cloning a decade ago, TRPM8 channel has emerged as a promising prognostic marker and a putative therapeutic target in prostate cancer (PCa). However, recent studies have brought to light the complexity of TRPM8 isoforms in PCa. Consequently, the respective role of each TRPM8 isoform needs to be deciphered prior to considering TRPM8 as an ...
Multi-platform molecular profiling of a large cohort of glioblastomas reveals potential therapeutic strategies.
...Published in Oncotarget
Glioblastomas (GBM) are the most aggressive and prevalent form of gliomas with abysmal prognosis and limited treatment options. We analyzed clinically relevant molecular aberrations suggestive of response to therapies in 1035 GBM tumors. Our analysis revealed mutations in 39 genes of 48 tested. IHC revealed expression of PD-L1 in 19% and PD-1 in 46...
Discovery and characterization of Isofistularin-3, a marine brominated alkaloid, as a new DNA demethylating agent induci...
...Published in Oncotarget
We characterized the brominated alkaloid Isofistularin-3 (Iso-3), from the marine sponge Aplysina aerophoba, as a new DNA methyltransferase (DNMT)1 inhibitor. Docking analysis confirmed our in vitro DNMT inhibition data and revealed binding of Iso-3 within the DNA binding site of DNMT1. Subsequent increased expression of tumor suppressor gene aryl ...
