Ahlbach, Christopher L Lexa, Katrina W Bockus, Andrew T Chen, Valerie Crews, Phillip Jacobson, Matthew P Lokey, R Scott
Published in
Future medicinal chemistry
Many cyclic peptide natural products are larger and structurally more complex than conventional small molecule drugs. Although some molecules in this class are known to possess favorable pharmacokinetic properties, there have been few reports on the membrane permeabilities of cyclic peptide natural products. Here, we present the passive membrane pe...
Xiao, Kai Suby, Nell Li, Yuanpei Lam, Kit S
Published in
Therapeutic delivery
PEG-dendritic block copolymer (telodendrimer) is a unique class of polymers with well-defined structures and tunable aggregation properties, which have been recently developed as novel micelle-based nanocarriers. This new class of nanocarrier is highly versatile, robust, multifunctional and has many unique properties for drug delivery that are supe...
Rolando Yanes Fuyuhiko Tamanoi
Published in
Therapeutic Delivery
The development of delivery vehicles that would carry therapeutic agents selectively to cancer cells has become an important focus in biomedical research. Nanoparticles have received much attention because the advances made in this field have resulted in multiple biocompatible materials. In particular, mesoporous silica nanoparticles (MSNs) offer a...
Simon Waddington
Published in
Therapeutic Delivery
Grewal, J Marlon G. Saria Grewal, Hk Santosh Kesari
Published in
Clinical Investigation
Neoplastic meningitis, also known as leptomeningeal metastases, is a complication of various types of cancer that occurs when tumor cells enter the cerebrospinal fluid (CSF), travel along CSF pathways and grow. Treatment options include drug delivery directly into the CNS or systemic administration for targeted action in the CNS. CNS drug delivery ...
Simon Waddington
Published in
Therapeutic Delivery
Lee, Joyce Kit S. Lam
Published in
Therapeutic Delivery
Eroy-Reveles, Aa Pradip Mascharak
Published in
Future Medicinal Chemistry
The discovery of various regulatory, protective and deleterious effects of nitric oxide (NO) has prompted intense research activity in the design and synthesis of NO-donating drugs and materials that can be used to modulate the effective concentrations of NO at biological targets. To date, various NO-donating compounds have been incorporated or imm...
