Zhang, Lei Tang, Shi Ma, Yue Liu, Junhang Monnier, Philippe Li, Hang Zhang, Rongrong Yu, Gang Zhang, Mengjie Li, Yongmei
...
Published in
Frontiers in Immunology
The infiltration of inflammatory cells into the central nervous system (CNS) through the dysfunctional blood–brain barrier (BBB) was critical in the early stages of MS. However, the mechanisms underlying BBB dysfunction remain unknown. Repulsive guidance molecule-a (RGMa) is involved in the pathogenesis of multiple sclerosis (MS), but its role need...
Liu, Pengju Zeng, Jianfeng Yang, Gaohua
Published in
Experimental and Therapeutic Medicine
The expression profile and role of yes-associated protein (YAP) in occurrence and development of breast cancer is ambiguous. The present study aimed to explore the relationship among the YAP, β-catenin and smoothened (SMO) signaling pathways to provide a theoretical basis for the clinical diagnosis and treatment of invasive breast cancer. Immunohis...
zhao;, guangfu
Pancreatic cancer is driven by risk factors such as diabetes and chronic pancreatic injury, which are further associated with gut dysbiosis. Intestinal toxins such as bile acids and bacterial endotoxin (LPS), in excess and persistence, can provoke chronic inflammation and tumorigenesis. Of interest is that many intestinal toxins are negatively char...
Zhao, Ye Lykov, Nikita Tzeng, Chimeng
Published in
International Journal of Molecular Medicine
The mechanical signals within the extracellular matrix (ECM) regulate cell growth, proliferation and differentiation, and integrins function as the hub between the ECM and cellular actin. Focal adhesions (FAs) are multi-protein, integrin-containing complexes, acting as tension-sensing anchoring points that bond cells to the extracellular microenvir...
Wu, Qian Xu, Xingxing Miao, Xuemeng Bao, Xiaomei Li, Xiuchun Xiang, Ludan Wang, Wei Du, Siyu Lu, Yi Wang, Xiwu
...
Published in
Stem cell reports
The horizontal basal cells (HBCs) of olfactory epithelium (OE) serve as reservoirs for stem cells during OE regeneration, through proliferation and differentiation, which is important in recovery of olfactory function. However, the molecular mechanism of regulation of HBC proliferation and differentiation after injury remains unclear. Here, we foun...
Li, Hongxia Wang, Yaping Su, Rina Jia, Yuchen Lai, Xiong Su, Huimin Fan, Yaochun Wang, Yuewu Xing, Wanjin Qin, Jianzhong
...
Published in
Frontiers in Oncology
Melanoma is a deadly form of skin cancer with high rates of resistance to traditional chemotherapy and radiotherapy. BRAF inhibitors (BRAFi) can achieve initial efficacy when used to treat melanoma patients, but drug resistance and relapse are common, emphasizing the need for new therapeutic strategies. Herein, we reported that combination of dimet...
Hasegawa, Takashi Sugihara, Takaaki Hoshino, Yoshiki Tarumoto, Ryohei Matsuki, Yukako Kanda, Tsutomu Takata, Tomoaki Nagahara, Takakazu Matono, Tomomitsu Isomoto, Hajime
...
Published in
Oncology letters
Yes-associated protein (YAP) positivity indicates a poor prognosis in gastric cancer. Transcriptional co-activator with a PDZ-binding domain (TAZ), a YAP paralog, is highly expressed in gastric signet ring cell carcinoma. Verteporfin (VP), a clinical photosensitizer, was recently shown to inhibit YAP/TAZ. In the present study, the therapeutic poten...
shim;, jenny
Neuroblastoma is the most common extra-cranial pediatric solid tumor that accounts for more than 15% of childhood cancer-related deaths. High risk neuroblastomas that recur during or after intense multimodal therapy have a
Zhang, Yijun Yan, Shumei Li, Yan Zhang, Jiangbo Luo, Yuan Li, Pengcheng Yang, Yuanzhong Li, Yong Huang, Yuhua Wang, Enhua
...
Published in
Molecular Medicine Reports
Inhibin βA (INHBA) serves a prognostic and tumor-promoting role in numerous types of cancer. The present study aimed to determine the clinical significance of INHBA in non-small cell lung cancer (NSCLC) and the mechanisms underlying its potential tumor-promoting effect. INHBA expression was detected in clinical NSCLC samples using immunohistochemis...
Huang, Bo Zhao, Yating Zhou, Lin Gong, Tingyu Feng, Jiawen Han, Peilin Qian, Jianhua
Published in
Journal of Inflammation Research
Purpose Peptidyl arginine deiminase, type VI (PADI6), a member of the subcortical maternal complex, plays an important role in oocyte growth and the development of fertilized oocytes. Human patients with PADI6 mutations can suffer from multiple reproductive deficiencies including hydatidiform moles and miscarriages. Recent studies have demonstrated...
