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Total energy expenditure TEE determines energy requirements but objective data in patients with cancer are limited We aimed to characterize TEE investigate its predictors and compare TEE with cancer-specific predicted energy requirements This cross-sectional analysis included patients with stages II-IV colorectal cancer from the Protein Recommendation to Increase Muscle PRIMe trial TEE was assessed by 24-h stay in a whole-room indirect calorimeter before dietary intervention and compared with cancer-specific predicted energy requirements 25-30 kcal kg Generalized linear models paired-samples t tests and Pearson correlation were applied Thirty-one patients 56 10 y body mass index BMI 27 9 5 5 kg m2 68 male were included Absolute TEE was higher in males mean difference 391 kcal d 95 CI 167 616 kcal d P 0 001 patients with colon cancer mean difference 279 kcal d 95 CI 73 485 kcal d P 0 010 and patients with obesity mean difference 393 kcal d 95 CI 182 604 kcal d P 0 001 Appendicular lean soft tissue 46 72 95 CI 34 27 59 17 P 0 001 and tumor location colon- 139 69 95 CI 19 44 259 95 P 0 023 independently predicted TEE when adjusted for sex Error between measured TEE and energy requirements predicted by 25 kcal kg mean difference 241 kcal d 95 CI 76 405 kcal d P 0 010 or 30 kcal kg mean difference 367 kcal d 95 CI 163 571 kcal d P 0 001 was higher for patients with obesity and proportional error was observed 25 kcal kg r -0 587 P 0 001 and 30 kcal kg r -0 751 P 0 001 TEE mean difference 25 kcal kg 95 CI 24 27 kcal kg was below predicted requirements using 30 kcal kg -430 322 kcal d P 0 001 This is the largest study to assess TEE of patients with cancer using whole-room indirect calorimeter and highlights the need for improved assessment of energy requirements in this population Energy requirements predicted using 30 kcal kg overestimated TEE by 1 44 times in a controlled sedentary environment and TEE was outside of the predicted requirement range for most Special considerations are warranted when determining TEE of patients with colorectal cancer such as BMI body composition and tumor location This is a baseline cross-sectional analysis from a clinical trial registered at clinicaltrials gov as NCT02788955 https clinicaltrials gov ct2 show NCT02788955 Copyright 2023 American Society for Nutrition Published by Elsevier Inc All rights reserved

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Total energy expenditure assessed by 24-h whole-room indirect calorimeter in patients with colorectal cancer: baseline f...

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with whole-body indirect calorimetry as keyword