Publication search
with whole blood transcriptomics as keyword
Martin, Katherine R Gamell, Cristina Tai, Tsin Yee Bonelli, Roberto Hansen, Jacinta Tatoulis, James Alhamdoosh, Monther Wilson, Nicholas Wicks, Ian
Published in
Clinical & Translational Immunology
Systemic inflammatory response syndrome (SIRS) is a major complication associated with cardiopulmonary bypass (CPB). In this study, we used whole blood transcriptomics to reveal neutrophils and G‐CSF as major regulators of CPB‐induced systemic inflammation. Our results suggest that short‐term targeting of G‐CSF could provide a novel therapeutic str...
Tarca, Adi L. Pataki, Bálint Ármin Romero, Roberto Sirota, Marina Guan, Yuanfang Kutum, Rintu Gomez-Lopez, Nardhy Done, Bogdan Bhatti, Gaurav Yu, Thomas
...
Published in
Cell Reports Medicine
Harnessing the wisdom of crowds in a DREAM Challenge, Tarca et al. developed methods to predict gestational age and preterm birth from longitudinal multi-omics data. The authors show that blood RNAs predict ultrasound-based gestational age, and they identify molecular changes preceding a diagnosis of spontaneous preterm birth in asymptomatic women....
Tarca, Adi L Pataki, Bálint Ármin Romero, Roberto Sirota, Marina Guan, Yuanfang Kutum, Rintu Gomez-Lopez, Nardhy Done, Bogdan Bhatti, Gaurav Yu, Thomas
...
Identification of pregnancies at risk of preterm birth (PTB), the leading cause of newborn deaths, remains challenging given the syndromic nature of the disease. We report a longitudinal multi-omics study coupled with a DREAM challenge to develop predictive models of PTB. The findings indicate that whole-blood gene expression predicts ultrasound-ba...
Tarca, Adi L Pataki, Bálint Ármin Romero, Roberto Sirota, Marina Guan, Yuanfang Kutum, Rintu Gomez-Lopez, Nardhy Done, Bogdan Bhatti, Gaurav Yu, Thomas
...
Identification of pregnancies at risk of preterm birth (PTB), the leading cause of newborn deaths, remains challenging given the syndromic nature of the disease. We report a longitudinal multi-omics study coupled with a DREAM challenge to develop predictive models of PTB. The findings indicate that whole-blood gene expression predicts ultrasound-ba...
