Granit Mizrahi, Avital Gugenheim, Ahinoam Hamad, Haneen Hamed, Roa’a Tetro, Nino Maimon, Ofra Khutsurauli, Salome Nechushtan, Hovav Nisman, Benjamin Duran, Deborah
...
Published in
Frontiers in Cell and Developmental Biology
We recently demonstrated that the histone deacetylase inhibitor valproic acid (VPA) reprograms the cisplatin-induced metabolome of triple-negative breast cancer (TNBC) cells, including a shift in hexose levels. Accordingly, here, we tested the hypothesis that VPA alters glucose metabolism in correlation with cisplatin sensitivity. Two TNBC cell lin...
Zhang, Lina Liu, Maochang Qin, Weiwei Shi, Dandan Mao, Junjun Li, Zeyun
Published in
Frontiers in Pharmacology
Background: Several studies have investigated the population pharmacokinetics (popPK) of valproic acid (VPA) in children with epilepsy. However, the predictive performance of these models in the extrapolation to other clinical environments has not been studied. Hence, this study evaluated the predictive abilities of pediatric popPK models of VPA an...
Awchi, Mo Singh, Kapil Dev Dill, Patricia E Frey, Urs Datta, Alexandre N Sinues, Pablo
Published in
Journal of Breath Research
Therapeutic drug monitoring (TDM) of medications with a narrow therapeutic window is a common clinical practice to minimize toxic effects and maximize clinical outcomes. Routine analyses rely on the quantification of systemic blood concentrations of drugs. Alternative matrices such as exhaled breath are appealing because of their inherent non-invas...
Hersi, Hire Peltola, Jukka Raitanen, Jani Saarinen, Jukka T.
Published in
Frontiers in Neurology
Objective We evaluate the effect of distinct clinical features on anti-seizure medication (ASM) doses in seizure-free and not seizure-free patients aged ≥16 years with new-onset epilepsy. Materials and methods This study included 459 patients with a validated diagnosis of epilepsy. The most prescribed ASMs were oxcarbazepine (OXC; n = 307), followe...
Lehmann, Leanne M. Barker-Haliski, Melissa
Published in
Frontiers in Neurology
Introduction Patients with early-onset Alzheimer's disease (EOAD) experience seizures and subclinical epileptiform activity, which may accelerate cognitive and functional decline. Antiseizure medicines (ASMs) may be a tractable disease-modifying strategy; numerous ASMs are marketed with well-established safety. However, little information is availa...
Preda, Adrian
Published in
Frontiers in Pharmacology
Ogawa, Takao Matsumoto, Koji Tojima, Ichiro Kikuoka, Hirotaka Hira, Daiki Shimizu, Takeshi
Published in
The Annals of otology, rhinology, and laryngology
Although some patients with postviral olfactory dysfunction (PVOD) recover spontaneously, many others are left with the degree of smell loss and there are no established drugs for the treatment of patients with PVOD. Valproic acid (VPA) has been widely used for the treatment of epilepsy. Its potential neuroregenerative effects have been shown via a...
Chen, Andi Wang, Mengmeng Xu, Chao Zhao, Youyi Xian, Panpan Li, Yuqian Zheng, Weian Yi, Xuyang Wu, Shengxi Wang, Yazhou
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Published in
Frontiers in Molecular Neuroscience
Pregnancy exposure of valproic acid (VPA) is widely adopted as a model of environmental factor induced autism spectrum disorder (ASD). Increase of excitatory/inhibitory synaptic transmission ratio has been proposed as the mechanism of VPA induced ASD. How this happened, particularly at the level of excitatory neuron differentiation in human neural ...
de León, Patricia Cañas-Arranz, Rodrigo Bustos, María José Sáiz, Margarita Sobrino, Francisco
Published in
Antimicrobial Agents and Chemotherapy
Antiviral compounds targeting cellular metabolism are part of the therapeutic arsenal to control the spread of virus infection, either as sole treatment or in combination with direct-acting antivirals (DAA) or vaccines. Here, we describe the effect of two of them, lauryl gallate (LG) and valproic acid (VPA) both exhibiting a wide antiviral spectrum...
Zhong, Jiu-Gen Lan, Wan-Ting Feng, Yan-Qing Li, Yin-Hua Shen, Ying-Ying Gong, Jia-Heng Zou, Zhi Hou, Xiaohui
Published in
Frontiers in Physiology
Introduction: The microbiota–gut–brain axis plays an important role in the pathophysiology of autism spectrum disorder, but its specific mechanisms remain unclear. This study aimed to explore the associations of changes in neurotransmitters and short-chain fatty acids with alterations in gut microbiota in valproic acid model rats. Methods: The auti...
