Editorial: Non-invasive and minimally invasive vagus nerve stimulation for chronic pain
Published in Frontiers in Pain Research
Editorial: Non-invasive and minimally invasive vagus nerve stimulation for chronic pain
Differential transcriptional profiles of vagal sensory neurons in female and male mice
Published in Frontiers in Neuroscience
Introduction Differences in metabolic homeostasis, diabetes, and obesity between males and females are evident in rodents and humans. Vagal sensory neurons in the vagus nerve ganglia innervate a variety of visceral organs and use specialized nerve endings to sense interoceptive signals. This visceral organ-brain axis plays a role in relaying intero...
Brain FADE syndrome: the final common pathway of chronic inflammation in neurological disease
Published in Frontiers in Immunology
Brain FADE Syndrome. Pictorial representation of the issues that patients face from disease pathogenesis to finding the correct type of physician to deal with Brain FADE Syndrome.
TRPV1 enhances cholecystokinin signaling in primary vagal afferent neurons and mediates the central effects on spontaneo...
Published in American journal of physiology. Cell physiology
The gut peptide cholecystokinin (CCK) is released during feeding and promotes satiation by increasing excitation of vagal afferent neurons that innervate the upper gastrointestinal tract. Vagal afferent neurons express CCK1 receptors (CCK1Rs) in the periphery and at central terminals in the nucleus of the solitary tract (NTS). While the effects of ...
Muscarinic acetylcholine receptors M2 are upregulated in the atrioventricular nodal tract in horses with a high burden o...
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Published in Frontiers in Cardiovascular Medicine
Background Second-degree atrioventricular (AV) block at rest is very common in horses. The underlying molecular mechanisms are unexplored, but commonly attributed to high vagal tone.Aim To assess whether AV block in horses is due to altered expression of the effectors of vagal signalling in the AV node, with specific emphasis on the muscarinic acet...
Vagus Nerve Stimulation Relives Irritable Bowel Syndrome and the Associated Depression via α7nAChR-mediated Anti-inflamm...
Published in Neuroscience
The present study is designed to investigate the role of vagus nerve in the treatments of irritable bowel syndrome (IBS) and the associated central nervous system disorders. An IBS animal model was established by giving acetic acid and chronic-acute stress (AA-CAS) treatment in adult male Wistar rats. Subdiaphragmatic vagotomy (SDV) and vagus nerve...
Insights in emotion regulation and processing: 2022
Published in Frontiers in Behavioral Neuroscience
The Vagus Nerve Mediates Gut-Brain Response to Duodenal Nutrient Administration.
Published in The American surgeon
Obesity contributes significant disease burden worldwide, including diabetes, cardiovascular disease, and cancer. While bariatric surgery is the most effective and durable obesity treatment, the mechanisms underlying its effects remain unknown. Although neuro-hormonal mechanisms have been suspected to mediate at least some of the gut-brain axis cha...
Impact of transcutaneous vagus nerve stimulation on healthy cognitive and brain aging
Published in Frontiers in Neuroscience
Evidence for clinically meaningful benefits of transcutaneous vagus nerve stimulation (VNS) has been rapidly accumulating over the past 15 years. This relatively novel non-invasive brain stimulation technique has been applied to a wide range of neuropsychiatric disorders including schizophrenia, obsessive compulsive disorder, panic disorder, post-t...
Perinatal high-fat diet exposure alters oxytocin and corticotropin releasing factor inputs onto vagal neurocircuits cont...
Published in The Journal of physiology
Perinatal high-fat diet (pHFD) exposure alters the development of vagal neurocircuits that control gastrointestinal (GI) motility and reduce stress resiliency in offspring. Descending oxytocin (OXT; prototypical anti-stress peptide) and corticotropin releasing factor (CRF; prototypical stress peptide) inputs from the paraventricular nucleus (PVN) o...
