Taniguchi, Satoshi Yoshikawa, Tomoki Shimojima, Masayuki Fukushi, Shuetsu Kurosu, Takeshi Tani, Hideki Fukuma, Aiko Kato, Fumihiro Nakayama, Eri Maeki, Takahiro
...
Published in
Viruses
Lymphocytic choriomeningitis virus (LCMV) is a prototypic arenavirus. The function of untranslated regions (UTRs) of the LCMV genome has not been well studied except for the extreme 19 nucleotide residues of both the 5′ and 3′ termini. There are internal UTRs composed of 58 and 41 nucleotide residues in the 5′ and 3′ UTRs, respectively, in the LCMV...
Stokes, Tanner Timmons, James A. Crossland, Hannah Tripp, Thomas R. Murphy, Kevin McGlory, Chris Mitchell, Cameron J. Oikawa, Sara Y. Morton, Robert W. Phillips, Bethan E.
...
Published in
Cell Reports
Stokes et al. identify and validate a core set of genes that are regulated in proportion to the magnitude of muscle protein turnover with loading. Several of these genes correlate with muscle growth only at their 3′ or 5′ untranslated region, and a subset directly influences protein synthesis in vitro .
Devaux, Frédéric Thiébaut, Antonin
Published in
Microbiology (Reading, England)
Iron is an essential element to most microorganisms, yet an excess of iron is toxic. Hence, living cells have to maintain a tight balance between iron uptake and iron consumption and storage. The control of intracellular iron concentrations is particularly challenging for pathogens because mammalian organisms have evolved sophisticated high-affinit...
Takenaka-Uema, Akiko Murakami, Shin Ushio, Nanako Kobayashi-Kitamura, Tomoya Uema, Masashi Uchida, Kazuyuki Horimoto, Taisuke
Published in
Viruses
We previously generated a recombinant reporter Akabane virus expressing enhanced green fluorescence protein (eGFP-AKAV), with an artificial S genome encoding eGFP in the ambisense RNA. Although the eGFP-AKAV was able to detect infected cells in in vivo histopathological study, its fluorescent signal was too weak to apply to in vivo imaging study. H...
Furuse, Yuki Chaimongkol, Natthawan Okamoto, Michiko Oshitani, Hitoshi
Published in
Viruses
The 5′ untranslated region (UTR) of the RNA genomes of enteroviruses possesses an internal ribosome entry site (IRES) that directs translation of the mRNA by binding to ribosomes. Infection with enterovirus D68 causes respiratory symptoms and is sometimes associated with neurological disorders. The number of reports of the viral infection and neuro...
Lee, M.H. Song, K.-Y. Hwang, H.J. Kim, J.H. Hwang, I.
One of the most crucial steps for preventing viral pandemics is the early detection of the causative virus on site. Various molecular and immunological approaches have been developed for virus detection. In this study, we investigated the utility of the recently introduced convection polymerase chain reaction (cPCR) platform for the rapid and sensi...
Furuse, Yuki Chaimongkol, Natthawan Okamoto, Michiko Oshitani, Hitoshi
The 5′ untranslated region (UTR) of the RNA genomes of enteroviruses possesses an internal ribosome entry site (IRES) that directs translation of the mRNA by binding to ribosomes. Infection with enterovirus D68 causes respiratory symptoms and is sometimes associated with neurological disorders. The number of reports of the viral infection and neuro...
Zhai, Ying Peng, Hao Neff, Michael M. Pappu, Hanu R.
Published in
Frontiers in Plant Science
Members of the virus order Bunyavirales cause serious diseases in animals, humans and plants. Family Tospoviridae in this order contains only one genus Orthotospovirus , and members in this genus exclusively infect plants. Tomato spotted wilt tospovirus (TSWV) is considered one of the most economically important plants viruses. Little is known abou...
Nakagomi, Takahiro Hirotsu, Yosuke Goto, Taichiro Shikata, Daichi Yokoyama, Yujiro Higuchi, Rumi Otake, Sotaro Amemiya, Kenji Oyama, Toshio Mochizuki, Hitoshi
...
Published in
Cancers
Lung cancer arises from the accumulation of genetic mutations, usually in exons. A recent study identified indel mutations in the noncoding region of surfactant-encoding genes in lung adenocarcinoma cases. In this study, we recruited 94 patients with 113 lung cancers (88 adenocarcinomas, 16 squamous cell carcinomas, and nine other histologies) who ...
Schuster, Samantha L Hsieh, Andrew C
Published in
Trends in cancer
The 5' and 3' untranslated regions (UTRs) regulate crucial aspects of post-transcriptional gene regulation that are necessary for the maintenance of cellular homeostasis. When these processes go awry through mutation or misexpression of certain regulatory elements, the subsequent deregulation of oncogenic gene expression can drive or enhance cancer...
