Plucińska, Kaja Jespersen, Naja Z. Brown, Erin L. Petersen, Patricia S. Rupar, Kaja Nielsen, Søren Scheele, Camilla Emanuelli, Brice
Published in
Frontiers in Endocrinology
Activation of thermogenic adipose tissue is linked to improved metabolic outcomes in mice and humans. Dissipation of energy as heat during thermogenesis relies on sufficient innervation of fat by sympathetic nerve fibers, a process recently proposed to be regulated by the adipose-specific calsyntenin3β (Clstn3β)-S100b axis. Here we aimed 1) to asse...
Lian, Hui Zhou, Li Zhang, Yang Song, Yan-Hai Zhang, Yi-Min Cao, Zheng-Hao Wang, Zhi-Yong
Published in
Anatomical record (Hoboken, N.J. : 2007)
To explore the possible mechanism of weight loss in Parkinson's disease (PD). Bilateral injections of 6-hydroxydopamine (6-OHDA) into substantia nigra (SN) were performed to induce the PD model rats. The rotarod test, food intake, body weight, and interscapular brown adipose tissue (IBAT) weight were recorded 6 weeks postoperation. HE staining was ...
Ikeda, Kenji Yamada, Tetsuya
Published in
Frontiers in Endocrinology
Mammals have two types of thermogenic adipocytes: brown adipocytes and beige adipocytes. Thermogenic adipocytes express high levels of uncoupling protein 1 (UCP1) to dissipates energy in the form of heat by uncoupling the mitochondrial proton gradient from mitochondrial respiration. There is much evidence that UCP1 is the center of BAT thermogenesi...
Klein Hazebroek, Marlou Keipert, Susanne
Published in
Frontiers in endocrinology
Fibroblast growth factor 21 (FGF21) is in biomedical focus as a treatment option for metabolic diseases, given that administration improves metabolism in mice and humans. The metabolic effects of exogenous FGF21 administration are well-characterized, but the physiological role of endogenous FGF21 has not been fully understood yet. Despite cold-indu...
Yamashita, Yukari Takeuchi, Tamaki Endo, Yuki Goto, Ayumi Sakaki, Setsuko Yamaguchi, Yuji Takenaka, Hiroyuki Yamashita, Hitoshi
Published in
Nutrients
We investigated the effect of evodiamine-containing microalga Dunaliella tertiolecta (DT) on the prevention of diet-induced obesity in a thermoneutral C57BL/6J male (30 °C). It attenuates the activity of brown adipose tissue (BAT), which accelerates diet-induced obesity. Nine-week-old mice were fed a high-fat diet supplemented with 10 g (Low group)...
Lee, Dong Ho Chang, Seo-Hyuk Yang, Dong Kwon Song, No-Joon Yun, Ui Jeong Park, Kye Won
Published in
Nutrients
Sesamol found in sesame oil has been shown to ameliorate obesity by regulating lipid metabolism. However, its effects on energy expenditure and the underlying molecular mechanism have not been clearly elucidated. In this study, we show that sesamol increased the uncoupling protein 1 ( Ucp1 ) expression in adipocytes. The administration of sesamol i...
Hankir, Mohammed K. Seyfried, Florian
Published in
Frontiers in Endocrinology
Bariatric surgeries induce marked and durable weight loss in individuals with morbid obesity through powerful effects on both food intake and energy expenditure. While alterations in gut-brain communication are increasingly implicated in the improved eating behavior following bariatric surgeries, less is known about the mechanistic basis for energy...
Bast-Habersbrunner, Andrea Fromme, Tobias
Published in
Frontiers in Endocrinology
Non-shivering thermogenesis in mammalian brown adipose tissue is a powerful mechanism to defend normothermia in cold climates. To minimize the loss of chemical energy, the central functional component, mitochondrial uncoupling protein 1, UCP1, must be tightly regulated. The canonical pathway of UCP1 activation includes lipolytic release of free fat...
Mao, Xiaoxiang Huang, Dandan Rao, Caijun Du, Meng Liang, Minglu Li, Fei Liu, Baoqing Huang, Kai
Published in
American journal of physiology. Endocrinology and metabolism
Browning of white adipose tissue (WAT) has been recognized as an important strategy for the treatment of obesity, insulin resistance, and diabetes. Enoyl coenzyme A hydratase 1 (ECH1) is a widely known enzyme involved in lipid metabolism. However, whether and how ECH1 is implicated in browning of WAT remain obscure. Adeno-associated, virus-mediated...
Li, Tiange Gong, Han Yuan, Qichen Du, Min Ren, Fazheng Mao, Xueying
Published in
FASEB journal : official publication of the Federation of American Societies for Experimental Biology
Promoting brown adipose tissue (BAT) function or browning of white adipose tissue (WAT) provides a defense against obesity. The aim of the study was to investigate whether maternal polar lipids-enriched milk fat globule membrane (MFGM-PL) supplementation to high-fat diet (HFD) rats during pregnancy and lactation could promote brown/beige adipogenes...
