McGarry, Niamh Murray, Carol L. Garvey, Sean Wilkinson, Abigail Tortorelli, Lucas Ryan, Lucy Hayden, Lorna Healy, Daire Griffin, Eadaoin. W. Hennessy, Edel
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Published in
bioRxiv
Double stranded RNA is generated during viral replication. The synthetic analogue poly I:C is frequently used to mimic anti-viral innate immune responses in models of psychiatric and neurodegenerative disorders including schizophrenia, autism, Parkinson’s disease and Alzheimer’s disease. Many studies perform limited analysis of innate immunity desp...
Upasani, Vinit Scagnolari, Carolina Frasca, Federica Smith, Nikaïa Bondet, Vincent Vanderlinden, Axelle Lay, Sokchea Auerswald, Heidi Heng, Sothy Laurent, Denis
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Published in
Frontiers in Immunology
The clinical presentation of dengue virus (DENV) infection is variable. Severe complications mainly result from exacerbated immune responses. Type I interferons (IFN-I) are important in antiviral responses and form a crucial link between innate and adaptive immunity. Their contribution to host defense during DENV infection remains under-studied, as...
Stanifer, Megan L. Guo, Cuncai Doldan, Patricio Boulant, Steeve
Published in
Frontiers in Immunology
Interferons (IFNs) constitute the first line of defense against microbial infections particularly against viruses. They provide antiviral properties to cells by inducing the expression of hundreds of genes known as interferon-stimulated genes (ISGs). The two most important IFNs that can be produced by virtually all cells in the body during intrinsi...
Lai, Yanni Zhang, Qiong Long, Haishan Han, Tiantian Li, Geng Zhan, Shaofeng Li, Yiwei Li, Zonghui Jiang, Yong Liu, Xiaohong
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Published in
Frontiers in Pharmacology
Background: Ganghuo Kanggan decoction (GHKGD) is a clinical experience prescription used for the treatment of viral pneumonia in the Lingnan area of China, and its clinical effect is remarkable. However, the mechanism of GHKGD in influenza is still unclear. Objective: To predict the active components and signaling pathway of GHKGD and to explore it...
Cai, Chunmei Hu, Zhiqiang Yu, Xiao
Published in
Frontiers in Cellular and Infection Microbiology
Malaria is a life-threatening infectious disease, affecting over 250 million individuals worldwide each year, eradicating malaria has been one of the greatest challenges to public health for a century. Growing resistance to anti-parasitic therapies and lack of effective vaccines are major contributing factors in controlling this disease. However, t...
Aschoff, Roland Zimmermann, Nick Beissert, Stefan Günther, Claudia
Published in
Dermatopathology
Contemporarily to the new SARS-CoV-2 mediated COVID-19 pandemic, a rise in patients with acral chilblain lesions has been described. They manifest late after mild disease or asymptomatic exposure to SARS-CoV-2. Their pathogenic evolution is currently unknown. In biopsies from three patients with acral partially ulcerating chilblain lesions that occ...
Huang, Xuewei Xu, Yigang Lin, Qingyu Guo, Weilong Zhao, Dongfang Wang, Chunmei Wang, Li Zhou, Han Jiang, Yanping Cui, Wen
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Published in
Virulence
The functions and profiles of lncRNAs during infectious bursal disease virus (IBDV) infection have not been determined, yet. The objectives of this study were to determine the antiviral action of loc107051710 lncRNA during IBDV infection by investigating the relationship between loc107051710 and IRF8, Type I IFN, STATs, and ISGs. DF-1 cells were ei...
Burman, Bharat Pesci, Giulio Zamarin, Dmitriy
Published in
Cancers
Preclinical and clinical studies dating back to the 1950s have demonstrated that Newcastle disease virus (NDV) has oncolytic properties and can potently stimulate antitumor immune responses. NDV selectively infects, replicates within, and lyses cancer cells by exploiting defective antiviral defenses in cancer cells. Inflammation within the tumor mi...
Darzianiazizi, Maedeh Mehrani, Yeganeh Chan, Lily Mould, Robert C Kulkarni, Raveendra R Sharif, Shayan Bridle, Byram W Karimi, Khalil
Published in
International journal of molecular sciences
Mast cells (MCs) are critical for initiating inflammatory responses to pathogens including viruses. Type I interferons (IFNs) that exert their antiviral functions by interacting with the type I IFN receptor (IFNAR) play a central role in host cellular responses to viruses. Given that virus-induced excessive toxic inflammatory responses are associat...
Storozynsky, Quinn Hitt, Mary M.
Published in
International Journal of Molecular Sciences
Radiotherapy is a major modality used to combat a wide range of cancers. Classical radiobiology principles categorize ionizing radiation (IR) as a direct cytocidal therapeutic agent against cancer; however, there is an emerging appreciation for additional antitumor immune responses generated by this modality. A more nuanced understanding of the imm...
