Rahman, Safrizal Sutedja, Endang Ayu, Onarisa Amirsyah, Mirnasari
Published in
Orthopedic Research and Reviews
Introduction Platelet-rich plasma (PRP) contains many growth factors, such as FGF, which induces the production of type I collagen, and VEGF, which induces neovascularization, all of which are important in bone healing. This study aimed to evaluate the effect of PRP administration on type I collagen production, VEGF expression, and neovascularizati...
zhang;, wu jingyi
Collagen from fish has been proven to have a low antigenicity that has no difference in the genetic codes compared with mammalian-based collagen. This study was designed to investigate the impact of tilapia skin collagen on immunogenicity and biocompatibility in vivo and in vitro. The structural characteristics of both acid-soluble and pepsin-solub...
gallo;, nunzia
Collagen is one of the most widely used biomaterials in health-related sectors. The industrial production of collagen mostly relies on its extraction from mammals, but several issues limited its use. In the last two decades, marine organisms attracted interest as safe, abundant, and alternative source for collagen extraction. In particular, the pos...
Stewart, Christopher C. O’Hara, Nathan N. Bzovsky, Sofia Bahney, Chelsea S. Sprague, Sheila Slobogean, Gerard P.
Published in
Bone & Joint Research
Aims Bone turnover markers (BTMs) follow distinct trends after fractures and limited evidence suggests differential levels in BTMs in patients with delayed healing. The effect of vitamin D, and other factors that influence BTMs and fracture healing, is important to elucidate the use of BTMs as surrogates of fracture healing. We sought to determine ...
Zhuang, Jianlong Chen, Chunnuan Chen, Yu'e Luo, Qi Wang, Yuanbai Jiang, Yuying Zeng, Shuhong Xie, Yingjun Chen, Dongmei
Published in
Frontiers in Pediatrics
Background Osteogenesis imperfecta (OI) is a rare heterogeneous disorder typically featured by fragile bones and susceptibility to fracture. The aim of the present study was to explore the genetic etiology of familial recurrent OI and the genotype–phenotype correlation. Methods Karyotyping, chromosomal microarray analysis, and whole-exome sequencin...
Sugiyama, Keita Miura, Jiro Shimizu, Masato Takashima, Aoi Matsuda, Yusuke Kayashima, Hiroki Okamoto, Motoki Nagashima, Tadashi Araki, Tsutomu
Published in
Oral diseases
The main aim of this study was to elucidate the effects of advanced glycation end products (AGEs) on the calcification of cultured rat dental pulp cells (RDPCs) and to investigate the crystallisation ability of glycated collagen. AGEs were prepared via non-enzymatic glycation of a dish coated with type I collagen using dl-glyceraldehyde. To investi...
Iwahashi, Hiroyasu Kawashima, Yoshihito Masaki, Hitoshi
Published in
Photodermatology, photoimmunology & photomedicine
Endo180 is involved in collagen remodeling by incorporating extracellular degraded collagen. Ultraviolet irradiation of dermal fibroblasts reduces Endo180 expression, which affects collagen fiber remodeling. However, it is unclear whether the decrease in Endo180 is directly related to the decrease in type I collagen fibers during photoaging. We aim...
banche-niclot;, federica
In bone regenerative strategies, the controlled release of growth factors is one of the main aspects for successful tissue regeneration. Recent trends in the drug delivery field increased the interest in the development of biodegradable systems able to protect and transport active agents. In the present study, we designed degradable poly(lactic-co-...
a., daryn
Bone strength and the incidence and severity of skeletal disorders vary significantly among human populations, due in part to underlying genetic differentiation. While clinical models predict that this variation is largely deleterious, natural population variation unrelated to disease can go unnoticed, altering our perception of how natural selecti...
Tang, Ruo-Fu Zhou, Xiao-Zhong Niu, Lie Qi, Yi-Ying
Published in
Bio-medical materials and engineering
Cartilage tissue lacks the ability to heal. Cartilage tissue engineering using cell-free scaffolds has been increasingly used in recent years. This study describes the use of a type I collagen scaffold combined with WNT5A plasmid to promote chondrocyte proliferation and differentiation in a rabbit osteochondral defect model. Type I collagen was ext...
