Chen, Junhui Yang, Jie Xu, Qingchun Wang, Zhenyu Wu, Jun Pan, Liukui Huang, Kai Wang, Chen
Published in
Bioscience Reports
Liver hepatocellular carcinoma (LIHC) is one of the most frequently occurring primary malignant liver tumors and seriously harms people’s health in the world. Methylenetetrahydrofolate dehydrogenase 1-like (MTHFD1L) has been shown to be associated with colon cancer cell proliferation, colony formation and invasion. In the present study, a total of ...
Xu, Huadan Li, Dong Ma, Jiaoyan Zhao, Yuanxin Xu, Long Tian, Rui Liu, Yanan Sun, Liankun Su, Jing
Published in
Cancer Biology & Medicine
Objective: Macrophages are a major component of the tumor microenvironment. M1 macrophages secrete pro-inflammatory factors that inhibit tumor growth and development, whereas tumor-associated macrophages (TAMs) mainly exhibit an M2 phenotype. Our previous studies have shown that the interleukin-33/ST2 (IL-33/ST2) axis is essential for activation of...
He, Chuanshi Li, Ling Wang, Linlin Meng, Wanrong Hao, Yaying Zhu, Guiquan
Published in
Cancer Biology & Medicine
Radiotherapy is one of the most effective treatment methods for various solid tumors. Bidirectional signal transduction between cancer cells and stromal cells within the irradiated microenvironment is important in cancer development and treatment responsiveness. Exosomes, initially considered as “garbage bins” for unwanted from cells, are now under...
Srivastava, Akhil Rathore, Shipra Munshi, Anupama Ramesh, Rajagopal
Published in
The AAPS Journal
Exosomes are involved in cell-to-cell communication and play a crucial role in cellular physiology. The role of exosomes in cancer has been widely explored. Tumor cells have evolved and adapted to evade the immune response. The study of the immune system’s modulations in favor of rogue tumor cells led to the development of a novel immunotherapeutic...
Bindea, Gabriela Mlecnik, Bernhard Galon, Jérôme
Published in
Oncoimmunology
The tumor microenvironment includes a complex network of cytokines and chemokines that contribute to shaping the intratumoral immune reaction. Understanding the mechanisms leading to immune-hot (Immunoscore-high) altered (excluded and immunosuppressed) and cold tumors are of critical importance for successful anti-cancer therapies. Two essential me...
Wang, Hanwen Ma, Huilin Sové, Richard J Emens, Leisha A Popel, Aleksander S
Published in
Journal for Immunotherapy of Cancer
Background Immune checkpoint blockade therapy has clearly shown clinical activity in patients with triple-negative breast cancer, but less than half of the patients benefit from the treatments. While a number of ongoing clinical trials are investigating different combinations of checkpoint inhibitors and chemotherapeutic agents, predictive biomarke...
Qi, Jia-long He, Jin-rong Jin, Shu-mei Yang, Xu Bai, Hong-mei Liu, Cun-bao Ma, Yan-bing
Published in
Frontiers in Oncology
Necroptosis is a form of programmed cell death (PCD) characterized by RIP3 mediated MLKL activation and increased membrane permeability via MLKL oligomerization. Tumor cell immunogenic cell death (ICD) has been considered to be essential for the anti-tumor response, which is associated with DC recruitment, activation, and maturation. In this study,...
Chen, Xingyu Li, Yongyun Yao, Tengteng Jia, Renbing
Published in
Frontiers in Cell and Developmental Biology
As a promising in vivo tool for cancer research, zebrafish have been widely applied in various tumor studies. The zebrafish xenograft model is a low-cost, high-throughput tool for cancer research that can be established quickly and requires only a small sample size, which makes it favorite among researchers. Zebrafish patient-derived xenograft (zPD...
Lindo, Lorenzo Wilkinson, Lauren Hanna Hay, Kevin Anthony
Published in
Frontiers in Immunology
T-cells genetically engineered to express a chimeric antigen receptor (CAR) have shown remarkable results in patients with B-cell malignancies, including B-cell acute lymphoblastic leukemia, diffuse large B-cell lymphoma, and mantle cell lymphoma, with some promising efficacy in patients with multiple myeloma. However, the efficacy of CAR T-cell th...
Pan, Chuqing Wang, Yu Liu, Qianwen Hu, Yihuai Fu, Jianhua Xie, Xiuying Zhang, Shuishen Xi, Mian Wen, Jing
Published in
Oncoimmunology
The tumor microenvironment (TME) of esophageal squamous cell carcinoma (ESCC) impacts tumor progression but is poorly understood. We obtained tumor tissues from 279 patients after esophagectomy and characterized the TME in intraepithelial and stromal regions using multiplex fluorescent immunohistochemistry (mfIHC). A heterogeneous immune population...
