Gastman, Brian Agarwal, Piyush K Berger, Adam Boland, Genevieve Broderick, Stephen Butterfield, Lisa H Byrd, David Fecci, Peter E Ferris, Robert L Fong, Yuman
...
Published in
Journal for immunotherapy of cancer
Immunotherapy is now a cornerstone for cancer treatment, and much attention has been placed on the identification of prognostic and predictive biomarkers. The success of biomarker development is dependent on accurate and timely collection of biospecimens and high-quality processing, storage and shipping. Tumors are also increasingly used as source ...
Figueiredo, Ana Carolina Leal, Rita Rodrigues, Luís Romãozinho, Catarina Escada, Luís Sá, Helena Figueiredo, Arnaldo Alves, Rui
Published in
The journal of vascular access
Angiosarcomas are rare tumors, comprising less than 1% of all sarcomas. However, they portend a poor prognosis, as they tend to metastasize early, being of uttermost importance a prompt diagnosis and treatment. We present the case of a 55-year-old female with history of kidney transplantation, immunosuppressed with tacrolimus, prednisolone, and mof...
Hong, Liang Pliss, Artem M. Zhan, Ye Zheng, Wenhan Xia, Jun Liu, Liwei Qu, Junle Prasad, Paras N.
Published in
Nanomaterials
Sonodynamic therapy (SDT) has emerged as an important modality for cancer treatment. SDT utilizes ultrasound excitation, which overcomes the limitations of light penetration in deep tumors, as encountered by photodynamic therapy (PDT) which uses optical excitations. A comparative study of these modalities using the same sensitizer drug can provide ...
Hong, Tae Hee Cha, Hongui Shim, Joon Ho Lee, Boram Chung, Jongsuk Lee, Chung Kim, Nayoung K D Choi, Yoon-La Hwang, Soohyun Lee, Yoomi
...
Published in
Journal for Immunotherapy of Cancer
Background Tumor mutational burden (TMB) measurement is limited by low tumor purity of samples, which can influence prediction of the immunotherapy response, particularly when using whole-exome sequencing-based TMB (wTMB). This issue could be overcome by targeted panel sequencing-based TMB (pTMB) with higher depth of coverage, which remains unexplo...
Russick, Jules Joubert, Pierre-Emmanuel Gillard-Bocquet, Mélanie Torset, Carine Meylan, Maxime Petitprez, Florent Dragon-Durey, Marie-Agnes Marmier, Solenne Varthaman, Aditi Josseaume, Nathalie
...
Published in
Journal for Immunotherapy of Cancer
Background Natural killer (NK) cells play a crucial role in tumor immunosurveillance through their cytotoxic effector functions and their capacity to interact with other immune cells to build a coordinated antitumor immune response. Emerging data reveal NK cell dysfunction within the tumor microenvironment (TME) through checkpoint inhibitory molecu...
Korbecki, Jan Grochans, Szymon Gutowska, Izabela Barczak, Katarzyna Baranowska-Bosiacka, Irena
Published in
International Journal of Molecular Sciences
CC chemokines (or β-chemokines) are 28 chemotactic cytokines with an N-terminal CC domain that play an important role in immune system cells, such as CD4+ and CD8+ lymphocytes, dendritic cells, eosinophils, macrophages, monocytes, and NK cells, as well in neoplasia. In this review, we discuss human CC motif chemokine ligands: CCL1, CCL3, CCL4, CCL5...
Vaidya, Pranjal Bera, Kaustav Patil, Pradnya D Gupta, Amit Jain, Prantesh Alilou, Mehdi Khorrami, Mohammadhadi Velcheti, Vamsidhar Madabhushi, Anant
Published in
Journal for Immunotherapy of Cancer
Purpose Hyperprogression is an atypical response pattern to immune checkpoint inhibition that has been described within non-small cell lung cancer (NSCLC). The paradoxical acceleration of tumor growth after immunotherapy has been associated with significantly shortened survival, and currently, there are no clinically validated biomarkers to identif...
Huang, Shile
Published in
Cells
The mechanistic/mammalian target of rapamycin (mTOR), a serine/threonine kinase, is a central regulator for human physiological activity. Deregulated mTOR signaling is implicated in a variety of disorders, such as cancer, obesity, diabetes, and neurodegenerative diseases. The papers published in this special issue summarize the current understandin...
Zheng, Wenqian Wang, Xiaowei Hu, Jinhui Bai, Bingjun Zhu, Hongbo
Published in
Oncology Reports
Aspartate/asparagine β-hydroxylase (AspH) is a type II transmembrane protein that catalyzes the post-translational hydroxylation of definite aspartyl and asparaginyl residues in epidermal growth factor-like domains of substrates. In the last few decades, accumulating evidence has indicated that AspH expression is upregulated in numerous types of hu...
Kawai, Kazuki Nishimura, Kai Okada, Satoshi Sato, Shinichi Suzuki, Minoru Takata, Takushi Nakamura, Hiroyuki
Published in
Molecular pharmaceutics
Cyclic RGD (cRGD) peptide-conjugated boronated albumin was developed to direct toward integrin αvβ3, which overexpresses on many cancer cells. A stepwise conjugation of c[RGDfK(Mal)] and maleimide-conjugated closo-dodecaborate (MID) to bovine serum albumin (BSA) afforded cRGD-MID-BSA, which was noncytotoxic toward both U87MG and A549 cells. As comp...
