Schuldt, Maike Pei, Jiayi Harakalova, Magdalena Dorsch, Larissa M. Schlossarek, Saskia Mokry, Michal Knol, Jaco C. Pham, Thang V. Schelfhorst, Tim Piersma, Sander R.
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Published in
Circulation. Heart Failure
Hypertrophic cardiomyopathy (HCM) is the most common genetic heart disease. While ≈50% of patients with HCM carry a sarcomere gene mutation (sarcomere mutation-positive, HCMSMP), the genetic background is unknown in the other half of the patients (sarcomere mutation-negative, HCMSMN). Genotype-specific differences have been reported in cardiac func...
Vicente, Carlos Legaz, María-Estrella Sánchez-Elordi, Elena
Published in
Journal of Fungi
Sugar cane smut ( Sporisorium scitamineum ) interactions have been traditionally considered from the plant’s point of view: How can resistant sugar cane plants defend themselves against smut disease? Resistant plants induce several defensive mechanisms that oppose fungal attacks. Herein, an overall view of Sporisorium scitamineum’s mechanisms of in...
Devi, Neha Kaur, Kamalpreet Biharee, Avadh Jaitak, Vikas
Published in
Anti-cancer agents in medicinal chemistry
Cancer accounts for several deaths each year. There are multiple FDA approved drugs for cancer treatments. Due to the severe side effects and multiple drug resistance, the current drug therapies become ineffective. So, the newer moieties with fewer toxic effects are necessary for the development. The mechanism of indole derivatives as anti-cancer a...
Mendez-Pfeiffer, Pablo Alday, Efrain Carreño, Ana Laura Hernández-Tánori, Jorge Montaño-Leyva, Beatriz Ortega-García, Jesús Valdez, Judith Garibay-Escobar, Adriana Hernandez, Javier Valencia, Dora
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Published in
Antioxidants (Basel, Switzerland)
The main chemical composition and pharmacological potential of propolis from arid and semi-arid regions of the Sonoran Desert have been previously reported. Caborca propolis (CP), from an arid zone of the Sonoran Desert, has shown a polyphenolic profile that suggests a mixed plant origin, presenting poplar-type markers, as well as a 6-methoxylated ...
Domart, Florelle Cloetens, Peter Roudeau, Stéphane Carmona, Asuncion Verdier, Emeline Choquet, Daniel Ortega, Richard
Published in
eLife
Zinc and copper are involved in neuronal differentiation and synaptic plasticity but the molecular mechanisms behind these processes are still elusive due in part to the difficulty of imaging trace metals together with proteins at the synaptic level. We correlate stimulated emission depletion microscopy of proteins and synchrotron X-ray fluorescenc...
Lin, Chin-Hsien Lin, Han-Yi Fang, Jim-Min Chen, Ching-Chow
Published in
Aging
Parkinson's disease (PD) is among the most common neurodegenerative disorders, and its etiology involves both genetic and environmental factors. The leucine-rich repeat kinase (LRRK2) G2019S mutation is the most common genetic cause of familial and sporadic PD. Current treatment is limited to dopaminergic supplementation, as no disease-modifying th...
Meyenberg Cunha-de Padua, Monique Fabbri, Lucilla Dufies, Maeva Lacas-Gervais, Sandra Contenti, Julie Voyton, Charles Fazio, Sofia Irondelle, Marie Mograbi, Baharia Rouleau, Matthieu
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Published in
Cancers
Simple Summary Here, we demonstrate that the hypoxia-induced cleaved form of VDAC1 (VDAC1-ΔC) reprograms the cell to utilize more metabolites and is implicated in up-regulation of glycolysis and mitochondrial respiration, conferring a direct survival advantage in hypoxic microenvironment. We further highlight a direct relationship between VDAC1-ΔC,...
Benassi, Alessandra Doria, Filippo Pirota, Valentina
Published in
International journal of molecular sciences
Nowadays, an increasing number of heterocyclic-based drugs found application in medicinal chemistry and, in particular, as anticancer agents. In this context, oxadiazoles-five-membered aromatic rings-emerged for their interesting biological properties. Modification of oxadiazole scaffolds represents a valid strategy to increase their anticancer act...
Ibrahim, Tarek S. Hawwas, Mohamed M. Malebari, Azizah M. Taher, Ehab S. Omar, Abdelsattar M. O’Boyle, Niamh M. McLoughlin, Eavan Abdel-Samii, Zakaria K. Elshaier, Yaseen A. M. M.
Published in
Pharmaceuticals
A novel series of quinoline derivatives of combretastatin A-4 incorporating rigid hydrazone and a cyclic oxadiazole linkers were synthesized and have demonstrated potent tubulin polymerization inhibitory properties. Many of these novel derivatives have shown significant antiproliferative activities in the submicromolar range. The most potent compou...
Aseervatham, Jaya
Published in
Biology
Simple Summary Cell migration is an essential process from embryogenesis to cell death. This is tightly regulated by numerous proteins that help in proper functioning of the cell. In diseases like cancer, this process is deregulated and helps in the dissemination of tumor cells from the primary site to secondary sites initiating the process of meta...
