Morishita, Jun Nurse, Paul
Published in
Open Biology
Microtubules are critical for a variety of cellular processes such as chromosome segregation, intracellular transport and cell shape. Drugs against microtubules have been widely used in cancer chemotherapies, though the acquisition of drug resistance has been a significant issue for their use. To identify novel small molecules that inhibit microtub...
Pradhan, Pinkilata Margolin, William Beuria, Tushar Kant
Published in
Frontiers in Microbiology
Widespread antimicrobial resistance among bacterial pathogens is a serious threat to public health. Thus, identification of new targets and development of new antibacterial agents are urgently needed. Although cell division is a major driver of bacterial colonization and pathogenesis, its targeting with antibacterial compounds is still in its infan...
myrka, alexander buck, leslie
Polymerization of actin filaments and microtubules constitutes a ubiquitous demand for cellular adenosine-5′-triphosphate (ATP) and guanosine-5′-triphosphate (GTP). In anoxia-tolerant animals, ATP consumption is minimized during overwintering conditions, but little is known about the role of cell structure in anoxia tolerance. Studies of overwinter...
hajka, daria budziak, bartosz pietras, łukasz duda, przemysław mccubrey, james a. gizak, agnieszka
Glycogen synthase kinase 3 (GSK3) was initially isolated as a critical protein in energy metabolism. However, subsequent studies indicate that GSK-3 is a multi-tasking kinase that links numerous signaling pathways in a cell and plays a vital role in the regulation of many aspects of cellular physiology. As a regulator of actin and tubulin cytoskele...
toniyan, konstantin a. povorova, victoria v. gorbacheva, elena yu. boyarintsev, valery v. ogneva, irina v.
(1) Background: Endometriosis is a common pathology of the female reproductive system, often accompanied by pain and decreased fertility. However, its pathogenesis has not been sufficiently studied regarding the role of the cytoskeleton. In this study, we describe two clinical cases involving rare localization of extragenital endometriosis (umbilic...
Quitmann, Christina M. Rust, Stephan Reunert, Janine Biskup, Saskia Fiedler, Barbara Marquardt, Thorsten
Published in
Child Neurology Open
Two siblings with an early onset of a neurodegenerative disease were presented with muscular hypotonia, secondary microcephaly, and severe developmental delay. Seizures were refractory to treatment but could be controlled with a ketogenic diet. Over the course of 5 years, whole exome sequencing (WES) was performed twice in both children. The first ...
Wang, Guangcheng Liu, Wenjing Fan, Meiyan He, Min Li, Yongjun Peng, Zhiyun
Published in
Journal of Enzyme Inhibition and Medicinal Chemistry
A novel series of thiazole-naphthalene derivatives as tubulin polymerisation inhibitors were designed, synthesised, and evaluated for the anti-proliferative activities. The majority of the tested compounds exhibited moderate to potent antiproliferative activity on the MCF-7 and A549 cancer cell lines. Among them, compound 5b was found to be the mos...
antúnez-mojica, mayra romero-estrada, antonio hurtado-díaz, israel miranda-molina, alfonso alvarez, laura
Bursera fagaroides is a medicinal tree endemic to México, it belongs to the Burseraceae family and has proven antitumor activity. Modern research, performed principally with the bark extracts, have indicated that lignans are the main active constituents of B. fagaroides, with a high content of aryltetralin, aryldihydronaphtalene, dibenzylbutirolact...
rostovtseva, tatiana k. bezrukov, sergey m. hoogerheide, david p.
The voltage-dependent anion channel (VDAC) is the primary regulating pathway of water-soluble metabolites and ions across the mitochondrial outer membrane. When reconstituted into lipid membranes, VDAC responds to sufficiently large transmembrane potentials by transitioning to gated states in which ATP/ADP flux is reduced and calcium flux is increa...
Costa, José Hélio Mohanapriya, Gunasekaran Bharadwaj, Revuru Noceda, Carlos Thiers, Karine Leitão Lima Aziz, Shahid Srivastava, Shivani Oliveira, Manuela Gupta, Kapuganti Jagadis Kumari, Aprajita
...
Published in
Frontiers in Immunology
In a perspective entitled ‘From plant survival under severe stress to anti-viral human defense’ we raised and justified the hypothesis that transcript level profiles of justified target genes established from in vitro somatic embryogenesis (SE) induction in plants as a reference compared to virus-induced profiles can identify differential virus sig...
