Vilchèze, Catherine Jacobs, William R Jr
Published in
Antimicrobial agents and chemotherapy
N-acetylcysteine (NAC) is most commonly used for the treatment of acetaminophen overdose and acetaminophen-induced liver injury. In patients infected with Mycobacterium tuberculosis, the causative agent of tuberculosis (TB), NAC is given to treat hepatotoxicity induced by TB drugs. We had previously shown that cysteine, a derivative of NAC, potenti...
Yang, Xinggui Chen, Xu Huang, Junfei Chen, Yijiang Zheng, Wenlin Chen, Wei Chen, Huijuan Lei, Shiguang Li, Shijun
Published in
ACS infectious diseases
Tuberculosis (TB) is a chronic infectious disease caused by the etiological agent Mycobacterium tuberculosis (MTB). Because the majority of TB patients come from poor economic backgrounds, the development of a simple, specific, low-cost, and highly sensitive detection method for the pathogen is extremely important for the prevention and treatment o...
Katariya, Mona M Snee, Matthew Tunnicliffe, Richard B Kavanagh, Madeline E Boshoff, Helena IM Amadi, Cecilia N Levy, Colin W Munro, Andrew W Abell, Chris Leys, David
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Mycobacterium tuberculosis (Mtb) was responsible for approximately 1.6 million deaths in 2021. With the emergence of extensive drug resistance, novel therapeutic agents are urgently needed, and continued drug discovery efforts required. Host-derived lipids such as cholesterol support Mtb growth, and are also suspected to function in immunomodulatio...
Boldi, Marc-Olivier Denis-Lessard, Justin Neziri, Rina Brouillet, René von-Garnier, Christophe Chavez, Valérie Mazza-Stalder, Jesica Jaton, Katia Greub, Gilbert Opota, Onya
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Published in
Frontiers in Cellular and Infection Microbiology
Background The microbial diagnosis of tuberculosis (TB) remains challenging and relies on multiple microbiological tests performed on different clinical specimens. Polymerase chain reactions (PCRs), introduced in the last decades has had a significant impact on the diagnosis of TB. However, questions remain about the use of PCRs in combination with...
Nurminen, Pertti Ettala, Otto Uusitalo-Seppälä, Raija Högerman, Mikael Kaipia, Antti Boström, Peter J
Published in
BJU international
To investigate the timing of the clinical presentation of various types of bacille Calmette-Guérin (BCG) infections in a Finnish population of patients with bladder cancer treated with BCG instillation therapy. We identified patients with a history of post-instillation BCG infection from 1996 to 2016 using the Finnish Cancer Registry and the Finnis...
Baluku, Joseph Baruch Nabwana, Martin Mwanahamisi, Suleiman Bwika Kansiime, Grace Nuwagira, Edwin Turyahabwe, Stavia Kirenga, Bruce
Published in
HIV medicine
Our objective was to determine associations between early (≤2 months) culture conversion (ECC) among people with HIV and drug-resistant tuberculosis (DRTB) in Uganda. This was a countrywide retrospective cohort of people with bacteriologically confirmed DRTB and a positive baseline culture at 16 centres in Uganda between 2013 and 2019. Data were ab...
Al-arbi, Khaled Mohamed Sefow Magula, Nombulelo P. Mody, Girish M.
Published in
Frontiers in Medicine
Objective: Infections are common in systemic lupus erythematosus (SLE), with tuberculosis (TB) being important in an endemic environment. We studied the prevalence and spectrum of TB in SLE in Durban, South Africa. Methods: A medical records review of SLE patients seen over 13-year period, and the demographic data, clinical manifestations, laborato...
Vasilyeva, Irina A. Aksenova, Valentina A. Kazakov, Alexey V. Kiseleva, Yulia Y. Maryandyshev, Andrey O. Dolzhenko, Elena N. Abramchenko, Anna V. Klevno, Nadejda I. Glebov, Konstantin A. Panova, Anna E.
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Published in
Frontiers in Medicine
Introduction The tuberculin skin test has significant limitations for use in individuals vaccinated with BCG. The presence in the genome of Mycobacterium tuberculosis of the RDI region, which is absent in the genome of Mycobacterium bovis BCG and most non-tuberculous mycobacteria, made it possible to develop new skin tests, which include a skin tes...
du Preez, Charné Legoabe, Lesetja J Jordaan, Audrey Jesumoroti, Omobolanle J Warner, Digby F Beteck, Richard M
Published in
Chemical biology & drug design
Curcumin is a natural product that has been reported to exhibit myriad pharmacological properties, one of which is antitubercular activity. It demonstrates antitubercular activity by directly inhibiting Mycobacterium tuberculosis (M.tb) and also enhances immune responses that ultimately lead to the elimination of M.tb by macrophages. This natural p...
Xing, Zhenzhen Sun, Tieying Janssens, Jean-Paul Chai, Di Liu, Weiming Tong, Yaqi Wang, Yuxia Ma, Yali Pan, Mingming Cui, Jia
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Published in
Thorax
Pulmonary function impairment and chronic respiratory symptoms after tuberculosis are relatively common in low-income and middle-income countries. We aimed to estimate the impact of post-tuberculosis (post-TB) on pulmonary function. This large cross-sectional, population-based study included subjects aged 15 years or older with technically acceptab...
