Froechlich, Guendalina Gentile, Chiara Infante, Luigia Caiazza, Carmen Pagano, Pasqualina Scatigna, Sarah Cotugno, Gabriella D'Alise, Anna Morena Lahm, Armin Scarselli, Elisa
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Published in
International journal of molecular sciences
HER2-based retargeted viruses are in advanced phases of preclinical development of breast cancer models. Mesothelin (MSLN) is a cell-surface tumor antigen expressed in different subtypes of breast and non-breast cancer. Its recent identification as a marker of some triple-negative breast tumors renders it an attractive target, presently investigate...
Ali, Reem Alblihy, Adel Toss, Michael S. Algethami, Mashael Al Sunni, Rabab Green, Andrew R. Rakha, Emad A. Madhusudan, Srinivasan
Published in
Therapeutic Advances in Medical Oncology
Background: PARP inhibitor (PARPi) monotherapy is a new strategy in BRCA germ-line deficient triple negative breast cancer (TNBC). However, not all patients respond, and the development of resistance limits the use of PARPi monotherapy. Therefore, the development of alternative synthetic lethality strategy, including in sporadic TNBC, is a priority...
Guo, Zhanfang Primeau, Tina Luo, Jingqin Zhang, Cynthia Sun, Hua Hoog, Jeremy Gao, Feng Huang, Shixia Edwards, Dean P. Davies, Sherri R.
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Published in
Cancers
Simple Summary The objective of this study is to identify potential proteomic biomarkers in triple negative breast cancer (TNBC) that associate with response to PI3K inhibitors which are in clinical trials. We tested a panel of TNBC patient-derived xenograft (PDX) models for their tumor growth response to a pan-PI3K inhibitor, BKM120. Proteomic ana...
Ho, Yathsoeung Suphrom, Nungruthai Daowtak, Krai Potup, Pachuen Thongsri, Yordhathai Usuwanthim, Kanchana
Published in
Pharmaceuticals
Triple negative breast cancer is one of the most aggressive breast cancer type with abilities of early metastasis and chemoresistance. The tropical plant Citrus hystrix DC. has been reported to promote many biological activities including anticancer. However, the effect of C. hystrix against triple negative breast cancer has not yet been identified...
Wisitpongpun, Prapakorn Suphrom, Nungruthai Potup, Pachuen Nuengchamnong, Nitra Calder, Philip C. Usuwanthim, Kanchana
Published in
Pharmaceuticals
Moringa oleifera Lam. (MO) is a medicinal plant distributed across the Middle East, Asia, and Africa. MO has been used in the traditional treatment of various diseases including cancer. This study aimed to perform bioassay-guided fractionation and identification of bioactive compounds from MO leaf against MDA-MB-231 breast cancer cells. MO leaf was...
Niu, Lin Yang, Songhe Zhao, Xueying Liu, Xiaochao Si, Lina Wei, Meng Liu, Lei Cheng, Luyang Qiao, Yuebing Chen, Zhihong
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Published in
Molecular Medicine Reports
Triple negative breast cancer (TNBC) is a subtype of breast cancer characterized by an aggressive histology and poor prognosis, with limited treatment options in the clinic. In the present study, the effect of sericin, as an anti-cancer drug, on TNBC cell proliferation was investigated using a MTT assay, a colony formation assay and immunocytochemi...
Lusho, Sejdi Durando, Xavier Bidet, Yannick Molnar, Ioana Kossai, Myriam Bernadach, Maureen Lacrampe, Nathalie Veyssiere, Hugo Cavaille, Mathias Gay-Bellile, Mathilde
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Published in
Medicine
Triple negative breast cancer affects 10% to 20% of all women diagnosed with breast cancer. Due to its characteristics, treatment strategies are limited and metastatic recurrences are common in the first 5 years after treatment. However, not all patients affected by this disease develop metastases. Tumor-infiltrating lymphocytes have shown to be re...
Sha'fie, Muhammad Syahreel Azhad Rathakrishnan, Sharani Hazanol, Iffa Nadhira Dali, Mohd Haziq Izzazuddin Khayat, Mohd Ezuan Ahmad, Syahida Hussin, Yazmin Alitheen, Noorjahan Banu Jiang, Lin-Hua Syed Mortadza, Sharifah Alawieyah
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Published in
Antioxidants (Basel, Switzerland)
Microglial cells are the primary immune cell resident in the brain. Growing evidence indicates that microglial cells play a prominent role in alcohol-induced brain pathologies. However, alcohol-induced effects on microglial cells and the underlying mechanisms are not fully understood, and evidence exists to support generation of oxidative stress du...
Ouled Dhaou, Mona Kossai, Myriam Morel, Anne-Pierre Devouassoux-Shisheboran, Mojgan Puisieux, Alain Penault-Llorca, Frederique Radosevic-Robin, Nina
Published in
American Journal of Cancer Research
Spatial organization of tumor microenvironment (TME) may influence tumor response to immunomodulatory therapies. Zeb1 is a driver of epithelial-mesenchymal transition, with several roles in immune cell development, however its role in shaping of the immune TME is not fully explored. We conducted a pre-multiplex spatial analysis study to verify whet...
Xing, Li Tang, Xiaolong Wu, Kaikai Huang, Xiong Yi, Yi Huan, Jinliang
Published in
Aging
Triple-negative breast cancer (TNBC) is a special type of breast cancer, its tumor cell metastasis rate is much higher than other types, and at the same time has a high rate of postoperative recurrence, which significantly threatens the health of women. Thus, it is urgent to explore a new treatment for TNBC. MiR-106a-5p was up-regulated in TNBC tis...
