Harris, Steve Bonnici, Tim Keen, Thomas Lilaonitkul, Watjana White, Mark J. Swanepoel, Nel
Published in
Frontiers in Digital Health
Machine Learning for Health (ML4H) has demonstrated efficacy in computer imaging and other self-contained digital workflows, but has failed to substantially impact routine clinical care. This is no longer because of poor adoption of Electronic Health Records Systems (EHRS), but because ML4H needs an infrastructure for development, deployment and ev...
Assmus, Frauke; Driouich, Jean-Sélim; Abdelnabi, Rana; 96163; Vangeel, Laura; Touret, Franck; Adehin, Ayorinde; Chotsiri, Palang; Cochin, Maxime; Foo, Caroline S; Jochmans, Dirk; 15412;
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In the absence of drugs to treat or prevent COVID-19, drug repurposing can be a valuable strategy. Despite a substantial number of clinical trials, drug repurposing did not deliver on its promise. While success was observed with some repurposed drugs (e.g., remdesivir, dexamethasone, tocilizumab, baricitinib), others failed to show clinical efficac...
Ding, Linda Bradford, Carla Kuo, I-Lin Fan, Yankhua Ulin, Kenneth Khalifeh, Abdulnasser Yu, Suhong Liu, Fenghong Saleeby, Jonathan Bushe, Harry
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Published in
Frontiers in Oncology
The future of radiation oncology is exceptionally strong as we are increasingly involved in nearly all oncology disease sites due to extraordinary advances in radiation oncology treatment management platforms and improvements in treatment execution. Due to our technology and consistent accuracy, compressed radiation oncology treatment strategies ar...
Aquila, Giorgio Alaimo, Alessandra Marracino, Luisa Martino, Valeria Camponogara, Francesca Vieceli Dalla Sega, Francesco Fortini, Francesca Pannuti, Antonio Zanotti, Claudia Malagutti, Nicola
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Published in
Physiological reports
Chronic rhinosinusitis with nasal polyps is a widespread pathology characterized by persistent inflammation of nasal and paranasal mucosa. Although it represents one of the most frequent diseases of the nasal cavities, its etiology is still not completely elucidated. There is evidence suggesting that the Notch signaling, a highly conserved intercel...
Wei, Sheng Wang, Fushun Liu, Jianfeng Wang, Yang
Published in
Frontiers in Psychiatry
Behrendt, Marc
Published in
Biological Chemistry
The calcium-permeable cation channel TRPM3 can be activated by heat and the endogenous steroid pregnenolone sulfate. TRPM3’s best understood function is its role as a peripheral noxious heat sensor in mice. However, the channel is expressed in various tissues and cell types including neurons as well as glial and epithelial cells. TRPM3 expression p...
Oliva, Joan Pacini, Simone Canals, Josep M. Lim, Mayasari
Published in
Frontiers in Cell and Developmental Biology
Jin, Chentao Luo, Xiaoyun Li, Xiaoyi Zhou, Rui Zhong, Yan Xu, Zhoujiao Cui, Chunyi Xing, Xiaoqing Zhang, Hong Tian, Mei
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Published in
Cancer
During the past several decades, numerous studies have provided insights into biological characteristics of cancer cells and identified various hallmarks of cancer acquired in the tumorigenic processes. However, it is still challenging to image these distinctive traits of cancer to facilitate the management of patients in clinical settings. The rap...
Zhang, Can Fang, Evandro Fei Wang, Changning
Published in
Frontiers in Aging Neuroscience
Xu, R Liu, Y Zhou, Y Lin, W Yuan, Q Zhou, X Yang, Y
Published in
Journal of dental research
Calvaria development is distinct from limb formation. Craniosynostosis is a skull deformity characterized by premature cranial suture fusion due to the loss of the GNAS gene and, consequently, its encoded protein Gαs. This birth defect requires surgery, with potential lethal consequences. So far, hardly any early-stage nonsurgical interventions for...
