Lin, Shiwei Qi, Rongfeng Lin, Xiaoshan Chen, Shengli Zhang, Longjiang Qiu, Yingwei
Published in
Journal of magnetic resonance imaging : JMRI
Patients with hepatitis B virus-related cirrhosis (HBV-RC) exhibit progressive neurologic dysfunction from primary sensorimotor to high-order cognition, as their disease advances. However, the exact neurobiologic mechanisms and the potential association with gene-expression profiles are not fully understood. To explore the hierarchical disorganizat...
Brooks, Thomas G Manjrekar, Aditi Mrcˇela, Antonijo Grant, Gregory R
Published in
Journal of biological rhythms
To assess the consistency of biological rhythms across studies, 57 public mouse liver tissue timeseries totaling 1096 RNA-seq samples were obtained and analyzed. Only the control groups of each study were included, to create comparable data. Technical factors in RNA-seq library preparation were the largest contributors to transcriptome-level differ...
Yu, Haitao Wang, Fangzhou Wu, Jia-Jun Gong, Juan Bi, Shuguang Mao, Yumin Jia, Dongdong Chai, Gao-Shang
Published in
CNS neuroscience & therapeutics
The systematic molecular associations between the peripheral blood cells and brain in Alzheimer's disease (AD) remains unclear, which hinders our understanding of AD pathological mechanisms and the exploration of new diagnostic biomarkers. Here, we performed an integrated analysis of the brain and peripheral blood cells transcriptomics to establish...
Ovchinnikova, Tatiana V. Shi, Qiong
Published in
Frontiers in Marine Science
Barutcu, A. Rasim Black, Michael B. Nong, Andy
Published in
Frontiers in Toxicology
Introduction: While targeted investigation of key toxicity pathways has been instrumental for biomarker discovery, unbiased and holistic analysis of transcriptomic data provides a complementary systems-level perspective. However, in a systematic context, this approach has yet to receive comprehensive and methodical implementation. Methods: Here, we...
Lei, Yan Huang, Jianmei Xie, Zhongshui Wang, Can Li, Yihong Hua, Yutong Liu, Chuanxin Yuan, Ruijuan
Published in
Frontiers in Pharmacology
Background: Yuquan Pill (YQW) is a modern concentrated pill preparation of six herbs, namely, Ge Gen (Pueraria lobata Ohwi), Di huang (Rehmannia glutinosa Libosch.), Tian Huafen (Trichosanthes kirilowii Maxim.), Mai Dong (Ophiopogon japonicus (L. f.) Ker Gawl.), Wu Weizi (Schisandra chinensis (Turcz.) Baill.) and Gan Cao (Glycyrrhiza uralensis Fisc...
Zmienko, Agnieszka Wojciechowski, Paweł Figlerowicz, Marek
Published in
Frontiers in Plant Science
Woolsey, Courtney Strampe, Jamie Fenton, Karla A Agans, Krystle N Martinez, Jasmine Borisevich, Viktoriya Dobias, Natalie S Deer, Daniel J Geisbert, Joan B Cross, Robert W
...
Published in
The Journal of infectious diseases
The filovirus Bundibugyo virus (BDBV) causes severe disease with a mortality rate of approximately 20%-51%. The only licensed filovirus vaccine in the United States, Ervebo, consists of a recombinant vesicular stomatitis virus (rVSV) vector that expresses Ebola virus (EBOV) glycoprotein (GP). Ervebo was shown to rapidly protect against fatal Ebola ...
Pandey, Prachi Gupta, Aarti El-Sherif, Nahla
Published in
Frontiers in Plant Science
Chen, Yi-Ju Catto, Michael A. Pandey, Sudeep Leal-Bertioli, Soraya Abney, Mark Hunt, Brendan G. Bag, Sudeep Culbreath, Albert Srinivasan, Rajagopalbabu
Published in
Frontiers in Plant Science
Tomato spotted wilt orthotospovirus (TSWV) transmitted by thrips causes significant yield loss in peanut (Arachis hypogaea L.) production. Use of peanut cultivars with moderate field resistance has been critical for TSWV management. However, current TSWV resistance is often not adequate, and the availability of sources of tetraploid resistance to T...
