louie, ye dimitriadis, evdokia
The window of implantation (WOI) is a critical phase of the menstrual cycle during which the endometrial lining becomes receptive and facilitates embryo implantation. Drawing on findings from various branches of “omics”, including genomics, epigenomics, transcriptomics, proteomics, lipidomics, metabolomics, and microbiomics, this narrative review a...
shuwen, qi zhang, chunzi yan, junlin xiaoyan, ma zhong, yewei hou, wenhui zhang, juan pang, tuxia xiaoli, ma
Background: Alcoholic liver disease (ALD) is a significant global health concern, primarily resulting from chronic alcohol consumption, with oxidative stress as a key driver. The ethyl acetate extract of Cichorium glandulosum (CGE) exhibits antioxidant and hepatoprotective properties, but its detailed mechanism of action against ALD remains unclear...
Antonucci, Stefano Caron, Guillaume Dikwella, Natalie Krishnamurty, Sruthi Sankari Harster, Anthony Zarrin, Hina Tahanis, Aboud Heuvel, Florian Olde Danner, Simon M. Ludolph, Albert
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Published in
bioRxiv
Altered neuronal excitability and synaptic inputs to motoneurons are part of the pathophysiology of Amyotrophic Lateral Sclerosis. The cAMP/PKA pathway regulates both of them but therapeutic interventions at this level are limited by the lack of knowledge about suitable pharmacological entry points. Here we used transcriptomics on microdissected an...
schröder, sophie sakib, m. sadman krüger, dennis m. pena, tonatiuh burkhardt, susanne schütz, anna-lena sananbenesi, farahnaz fischer, andré
Aging leads to cognitive decline and increased risk of neurodegenerative diseases. While molecular changes in central nervous system (CNS) cells contribute to this decline, the mechanisms are not fully understood. Long non-coding RNAs (lncRNAs) are key regulators of cellular functions. Background/Objectives: The roles of lncRNAs in aging, especiall...
xinlu, li tian, zhongxiao haojie, li tan, lei zhang, yong changrong, ge wang, kun
This study investigated the effects of ultraviolet A (UVA) radiation on the blackness traits of Xichou Black-boned Chickens and their underlying molecular mechanisms through combined transcriptomic and metabolomic analyses. A total of 240 one-day-old Xichou Black-boned Chickens were randomly divided into four groups and exposed to different duratio...
jagadeesan, sasi kumar galuta, ahmad sandarage, ryan vimukthi tsai, eve chung
The adult human spinal cord harbors diverse populations of neural stem/progenitor cells (NSPCs) essential for neuroregeneration and central nervous system repair. While induced pluripotent stem cell (iPSC)-derived NSPCs offer significant therapeutic potential, understanding their molecular and functional alignment with bona fide spinal cord NSPCs i...
pozzobon, daniele bellezza, arianna giorgi, federico m.
Background: The human FOXM1 transcription factor controls cell cycle progression and genome stability, and it has been correlated to the onset and progression of many tumor types. Methods: In our study, we collected all recent sequence and quantitative transcriptomics data about FOXM1, testing its presence across vertebrate evolution and its upregu...
zhang, lu wang, suhua yang, xuele luqiu, he liqin, hu tang, rui jiguang, li liu, zhongsong
Plant growth and development require water, but excessive water hinders growth. Sesame (Sesamum indicum L.) is an important oil crop; it is drought-tolerant but sensitive to waterlogging, and its drought tolerance has been extensively studied. However, the waterlogging tolerance of sesame still has relatively few studies. In this study, two kinds o...
liu, pei-pei xin-yue, yu pan, qing-qing ren, jia-jun han, yu-xuan zhang, kai wang, yan huang, yin ban, tao
Background/Objectives: Septic cardiomyopathy (SCM) is a severe cardiac complication of sepsis, characterized by cardiac dysfunction with limited effective treatments. This study aimed to identify repurposable drugs for SCM by integrated multi-omics and network analyses. Methods: We generated a mouse model of SCM induced by lipopolysaccharide (LPS) ...
pellegrina, diogo wilson, heather l. mutwiri, george k. helmy, mohamed
Adjuvants are a diverse group of substances that can be added to vaccines to enhance antigen-specific immune responses and improve vaccine efficacy. The first adjuvants, discovered almost a century ago, were soluble crystals of aluminium salts. Over the following decades, oil emulsions, vesicles, oligodeoxynucleotides, viral capsids, and other comp...
