Bhandari, Sabin Kyrrestad, Ingelin Simón-Santamaría, Jaione Li, Ruomei Szafranska, Karolina Joanna Dumitriu, Gianina Sánchez Romano, Javier Smedsrød, Bård Sørensen, Karen Kristine
Published in
Frontiers in Pharmacology
Liver sinusoidal endothelial cells (LSECs) which make up the fenestrated wall of the hepatic sinusoids, are active scavenger cells involved in blood waste clearance and liver immune functions. Dexamethasone is a synthetic glucocorticoid commonly used in the clinic and as cell culture supplement. However, the response is dependent on tissue, cell ty...
Matsushima, Takahide Hiroshi, Asahara
Published in
Journal of biochemistry
Tendons and ligaments, crucial components of the musculoskeletal system, connect muscles to bones. In the realm of sports, tendons and ligaments are vulnerable tissues, with injuries such as Achilles tendon rupture and anterior cruciate ligament tears directly impacting an athlete's career. Furthermore, repetitive trauma and tissue degeneration can...
Grand, Ralph Stefan Pregnolato, Marco Baumgartner, Lisa Hoerner, Leslie Burger, Lukas Schübeler, Dirk
Published in
Molecular cell
Mammalian gene expression is controlled by transcription factors (TFs) that engage sequence motifs in a chromatinized genome, where nucleosomes can restrict DNA access. Yet, how nucleosomes affect individual TFs remains unclear. Here, we measure the ability of over one hundred TF motifs to recruit TFs in a defined chromosomal locus in mouse embryon...
Sandoval, Carina Nisson, Karly Fregoso, Oliver I.
Published in
mBio
The HIV accessory protein Vpr is multi-functional and required for viral replication in vivo, yet how Vpr enhances viral replication is unknown. Emerging literature suggests that a conserved function of Vpr is the engagement of the host DNA damage response (DDR). For example, Vpr activates DDR signaling, causes DDR-dependent cell cycle arrest, prom...
Sanku, Gowthami Rajasekaran, Ravikesavan Boopathi, Narayanan Manikanda Krishnamoorthy, Iyanar Santhanakrishnan, Vichangal Pridiuldi Mani, Vetriventhan
Published in
Frontiers in Sustainable Food Systems
Global food and nutritional security are being threatened by abiotic stresses such as drought, salinity, cold, and heat, owing to the rapid and deleterious effects of climate change. Millets represent an incredibly promising agricultural crop in terms of their potential to ensure global food security by virtue of their resiliency against climate ch...
Liu, Li Liu, Yao Min, Lulu Zhou, Zhenzhen He, Xingxing Xie, YunHan Cao, Waifang Deng, Shuyun Lin, Xiaoju He, Xionglei
...
Published in
Molecular biology and evolution
Pleiotropy, the phenomenon in which a single gene influences multiple traits, is a fundamental concept in genetics. However, the evolutionary mechanisms underlying pleiotropy require further investigation. In this study, we conducted parallel gene knockouts targeting 100 transcription factors in 2 strains of Saccharomyces cerevisiae. We systematica...
Yelina, Nataliya E Frangedakis, Eftychios Wang, Zhemin Schreier, Tina B Rever, Jenna Tomaselli, Marta Forestier, Edith CF Billakurthi, Kumari Ren, Sibo Bai, Yahui
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Chloroplasts develop from undifferentiated plastids in response to light. In angiosperms, after the perception of light, the Elongated Hypocotyl 5 (HY5) transcription factor initiates photomorphogenesis, and two families of transcription factors known as GOLDEN2-LIKE (GLK) and GATA are considered master regulators of chloroplast development. In add...
Otálora-Otálora, Beatriz Andrea Payán-Gómez, César López-Rivera, Juan Javier Pedroza-Aconcha, Natalia Belén Aristizábal-Guzmán, Claudia Isaza-Ruget, Mario Arturo Álvarez-Moreno, Carlos Arturo
Published in
Frontiers in Cellular and Infection Microbiology
Background The diagnosis and treatment of lung, colon, and gastric cancer through the histologic characteristics and genomic biomarkers have not had a strong impact on the mortality rates of the top three global causes of death by cancer. Methods Twenty-five transcriptomic analyses (10 lung cancer, 10 gastric cancer, and 5 colon cancer datasets) fo...
Chen, Fenqi Niu, Kuiju Ma, Huiling
Published in
Frontiers in Plant Science
Flower development is a crucial and complex process in the reproductive stage of plants, which involves the interaction of multiple endogenous signals and environmental factors. However, regulatory mechanism of flower development was unknown in alfalfa (Medicago sativa). In this study, the three stages of flower development of ‘M. sativa cv. Gannon...
Dou, Ruigang Liu, Rongfeng Su, Peng Yu, Xiaohui Xu, Yanzhao
Published in
Open Medicine
Gap junction protein beta 3 (GJB3) has been reported as a tumor suppressor in most tumors. However, its role in lung adenocarcinoma (LUAD) remains unknown. The purpose of this study is to explore the role of GJB3 in the prognosis and tumor microenvironment of LUAD patients. The data used in this study were acquired from The Cancer Genome Atlas, Gen...