Zhang, Hui Zhang, Faya Modrak, Samantha
Published in
Journal of leukocyte biology
Cytokines play critical roles in regulating iNKT cell development, activation, and maturation. TNF-α co-occurs with iNKT cells in steady-state and many disease conditions. How TNF-α affects iNKT cell function has not been thoroughly investigated. It was found that chronic alcohol consumption enhanced iNKT cell activation and maturation. The underly...
Rétaux, Sylvie
Published in
Biologie Aujourd’hui
Le poisson Astyanax mexicanus se présente sous deux formes très différentes : un morphe de rivière « normal », et un morphe cavernicole, aveugle et dépigmenté, vivant dans l’obscurité totale et permanente de grottes mexicaines. Cette espèce est en passe de devenir un modèle de choix en biologie évolutive et comparée, tant pour l’étude de l’évolutio...
Reboledo, Guillermo Agorio, Astrid Ponce De León, Inés
Published in
Journal of experimental botany
Transcription factors control gene expression, leading to regulation of biological processes that determine plant development and adaptation to the environment. Land colonization by plants occurred 450-470 million years ago and was accompanied by an increase in the complexity of transcriptional regulation associated to transcription factor gene exp...
Fernandez-Pozo, Noe Haas, Fabian B Gould, Sven B Rensing, Stefan A
Published in
Journal of experimental botany
Bryophytes are useful models for the study of plant evolution, development, plant-fungal symbiosis, stress responses, and gametogenesis. Additionally, their dominant haploid gametophytic phase makes them great models for functional genomics research, allowing straightforward genome editing and gene knockout via CRISPR or homologous recombination. U...
Zhang, Geng Yang, Xiaohui Xu, Fang Wei, Dan
Published in
Frontiers in Plant Science
Bauhinia variegata petals are colorful, rich in anthocyanins, and have ornamental, nutritional, and medicinal value. However, the regulatory mechanism of anthocyanin accumulation in B. variegata remains unclear. In this study, a combined analysis of the metabolome and transcriptome was performed in red and white B. variegata cultivars in the early,...
Muthuramalingam, Pandiyan Jeyasri, Rajendran Selvaraj, Anthonymuthu Shin, Hyunsuk Chen, Jen-Tsung Satish, Lakkakula Wu, Qiang-Sheng Ramesh, Manikandan
Published in
Frontiers in Genetics
Plant transcription factors (TFs) are significant players in transcriptional regulations, signal transduction, and constitute an integral part of signaling networks. MYB TFs are major TF superfamilies that play pivotal roles in regulation of transcriptional reprogramming, physiological processes, and abiotic stress (AbS) responses. To explore the u...
Liu, Dan Wan, Yue Qu, Ning Fu, Qiang Liang, Chao Zeng, Lingda Yang, Yang
Published in
Frontiers in Public Health
Although the role of hypoxia has been greatly explored and unveiled in glioblastoma (GBM), the mechanism of hypoxia-related long non-coding (lnc) RNAs has not been clearly understood. This study aims to reveal the crosstalk among hypoxia-related lncRNAs, tumor microenvironment (TME), and tumorigenesis for GBM. Gene expression profiles of GBM patien...
Gao, Guohong Deng, Aijun Liang, Shan Liu, Shengsheng Fu, Xinyi Zhao, Xiaoyan Yu, Zhilong
Published in
Frontiers in Immunology
Molecular classification based on transcriptional characteristics is often used to study tumor heterogeneity. Human cancer has different cell populations with distinct transcription in tumors, and their heterogeneity is the focus of tumor therapy. Our purpose was to explore the tumor heterogeneity of uveal melanoma (UM) through RNA sequencing (RNA-...
Koşar, Zafer Erbaş, Aykut
Published in
Frontiers in Soft Matter
DNA is the ultimate molecule that encodes life through genes. Genes positioned along the meter-long DNA molecule have to be expressed at the right time and in the right amount via strict regulatory processes. Regulation of a gene starts with the binding of a DNA-binding protein known as a transcription factor (TF) to a target regulatory element alo...
Zhong, Min-Er Huang, Ze-Ping Wang, Xun Cai, Du Li, Cheng-Hang Gao, Feng Wu, Xiao-Jian Wang, Wei
Published in
Frontiers in Oncology
Background Colorectal cancer (CRC) is a heterogeneous disease, and current classification systems are insufficient for stratifying patients with different risks. This study aims to develop a generalized, individualized prognostic consensus molecular subtype (CMS)-transcription factors (TFs)-based signature that can predict the prognosis of CRC. Met...
