Song, Zhongbang Zhao, Lu Ma, Wenna Peng, Zhongping Shi, Junli Pan, Feng Gao, Yulong Sui, Xueyi Rengel, Zed Chen, Qi
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Published in
Journal of experimental botany
Stomatal movement can be regulated by ABA signaling through synthesis of reactive oxygen species (ROS) in guard cells. By contrast, ethylene triggers the biosynthesis of antioxidant flavonols to suppress ROS accumulation and prevent ABA-induced stomatal closure; however, the underlying mechanism remains largely unknown. In this study, we isolated a...
Kumar, Rupesh Madhavan, Thirumurthy Ponnusamy, Kalaiarasan Sohn, Honglae Haider, Shazia
Published in
Frontiers in Genetics
Introduction: Kinesin family member 5A (KIF5A) is a motor neuron protein expressed in neurons and involved in anterograde transportation of organelles, proteins, and RNA. Variations in the KIF5A gene that interfere with axonal transport have emerged as a distinguishing feature in several neurodegenerative disorders, including hereditary spastic par...
Rodriguez-Sanchez, Alberto C. Gónzalez-Salazar, Luz A. Rodriguez-Orduña, Lorena Cumsille, Ándres Undabarrena, Agustina Camara, Beatriz Sélem-Mojica, Nelly Licona-Cassani, Cuauhtemoc
Published in
Frontiers in Microbiology
The natural products (NPs) biosynthetic gene clusters (BGCs) represent the adapting biochemical toolkit for microorganisms to thrive different microenvironments. Despite their high diversity, particularly at the genomic level, detecting them in a shake-flask is challenging and remains the primary obstacle limiting our access to valuable chemicals. ...
Qian, Tianmei Qiao, Pingping Lu, Yingnan Wang, Hongkui
Published in
Frontiers in Veterinary Science
Shanks, Robert M. Q. Atta, Sarah Stella, Nicholas A. Sundar-Raj, Chollapadi V. Romanowski, John E. Grewal, Arman S. Shanks, Hazel Q. Mumper, Sonya M. Dhaliwal, Deepinder K. Mammen, Alex
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Published in
Frontiers in Cellular and Infection Microbiology
Introduction Pseudomonas aeruginosa causes vision threatening keratitis. The LasR transcription factor regulates virulence factors in response to the quorum sensing molecule N-3-oxo-dodecanoyl-L-homoserine lactone. P. aeruginosa isolates with lasR mutations are characterized by an iridescent high sheen phenotype caused by a build-up of 2-heptyl-4-q...
Arnold, Levi Gomez, Juan Pineda Barry, Michael Yap, Marrion Jackson, Laura Ly, Thuc Standing, David Padhye, Subhash B. Biersack, Bernhard Anant, Shrikant
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Published in
Exploration of Targeted Anti-tumor Therapy
Aim: Head and neck squamous cell carcinoma (HNSCC) is the seventh most common cancer worldwide with a survival rate below fifty percent. Addressing meager therapeutic options, a series of small molecule inhibitors were screened for antitumor efficacy. The most potent analog, acryl-3,5-bis(2,4-difluorobenzylidene)-4-piperidone (DiFiD; A-DiFiD), demo...
Wei, Yulong Davenport, Timothy C Collora, Jack A Ma, Haocong Katherine Pinto-Santini, Delia Lama, Javier Alfaro, Ricardo Duerr, Ann Ho, Ya-Chi
Published in
Immunity
Understanding how HIV-1-infected cells proliferate and persist is key to HIV-1 eradication, but the heterogeneity and rarity of HIV-1-infected cells hamper mechanistic interrogations. Here, we used single-cell DOGMA-seq to simultaneously capture transcription factor accessibility, transcriptome, surface proteins, HIV-1 DNA, and HIV-1 RNA in memory ...
Zhang, Si-Ping Ye, Yi-Ping Hou, Jun Ye, Zi-Rui Wang, Zhi-Song Yu, Xiao-Quan Guo, Ding-Ding Wang, Yong He, Yong-Xing
Published in
Antimicrobial Agents and Chemotherapy
Type II toxin-antitoxin systems are highly prevalent in bacterial genomes and play crucial roles in the general stress response. Previously, we demonstrated that the type II antitoxin PfMqsA regulates biofilm formation through the global regulator AgtR in Pseudomonas fluorescens. Here, we found that both the C-terminal DNA-binding domain of PfMqsA ...
Bairami, Styliani Folia, Vasiliki Liampas, Ioannis Ntanasi, Eva Patrikelis, Panayiotis Siokas, Vasileios Yannakoulia, Mary Sakka, Paraskevi Hadjigeorgiou, Georgios Scarmeas, Nikolaos
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Published in
Medicina (Kaunas, Lithuania)
Background and Objectives: The present study explored the utilization of verbal fluency (VF) cognitive strategies, including clustering, switching, intrusions, and perseverations, within both semantic (SVF) and phonemic (PVF) conditions, across a continuum of neurocognitive decline, spanning from normal cognitive ageing (NC) to mild cognitive impai...
Kind, Laura Driver, Mark Raasakka, Arne Onck, Patrick R. Njølstad, Pål Rasmus Arnesen, Thomas Kursula, Petri
Published in
Frontiers in Molecular Biosciences
Hepatocyte nuclear factor 1α (HNF-1A) is a transcription factor with important gene regulatory roles in pancreatic β-cells. HNF1A gene variants are associated with a monogenic form of diabetes (HNF1A-MODY) or an increased risk for type 2 diabetes. While several pancreatic target genes of HNF-1A have been described, a lack of knowledge regarding the...
