Chlordecone (CLD) is a pesticide persisting in soils and contaminating food webs. CLD is sequestered in the liver and poorly metabolized into chlordecol (CLDOH). In vitro liver cell models were used to investigate the fate and mechanistic effects of CLD and CLDOH using multiomics. A 3D-cell model was used to investigate whether CLD and CLDOH can af...
Enniatins produced by Fusarium species belong to emerging mycotoxins commonly found in cereals and raising concern for food and feed. They are potentially toxic to humans and therefore represent a public health issue. However, due to the lack of toxicokinetic and toxicodynamic data that could be used to derive a Health-Based Guidance Value, enniati...
Food and feed production are affected worldwide by contamination with natural substances such as mycotoxins. These toxins are produced by various fungi (Aspergillus, Alternaria, Fusarium, Penicillium, etc.), some of which are responsible for diseases in livestock as well as in humans. Moreover, their increasing presence in food and feed may be favo...
Adverse Outcome Pathways (AOPs) have been proposed to facilitate mechanistic understanding of interactions of chemicals/materials with biological systems. Each AOP starts with a molecular initiating event (MIE) and possibly ends with adverse outcome(s) (AOs) via a series of key events (KEs). So far, the interaction of engineered nanomaterials (ENMs...
Acetamiprid is a pesticide active substance with insecticidal action whose approval was renewed by Commission Implementing Regulation (EU) 2018/113. In January 2022, the EFSA PPR Panel published a statement following a request from the European Commission to advise on human health or the environment based on new scientific evidence presented by Fra...
L’exposome est un concept né en 2005, émanant de Chris Wild. Il désigne l’ensemble des expositions environnementales auxquelles un individu est soumis de sa conception jusqu’à sa mort. Ce concept a été enrichi par de très nombreux chercheurs de diverses disciplines (épidémiologie, analytique, biologie, informatique) au fil des années et a abouti à ...
Nanomaterials (NMs) are defined as materials with at least one external dimension below 100 nm. Their small size confers them interesting unique physico-chemical properties, hence NMs are increasingly used in a diversity of applications. However, the specific properties of NMs could also make them more harmful than their bulk counterparts. Therefor...
Trichothecenes are naturally occurring chemicals, produced by fungi, that can be found in contaminated crops. Trichothecenes have the potential to indirectly damage DNA and exacerbate genotoxic effects of genotoxicants. However, genotoxicity data for most trichothecenes are limited and data gaps remain. Here we use the γH2AX/ pH3 assay to evaluate ...
The in vivo working group (WG) considered three topics: acceptable maximum doses for negative erythrocyte micronucleus (MN) tests; validation status of MN assays in non‐haematopoietic tissues; nuisance factors in the comet assay. The WG reached agreement on many issues, including: Negative erythrocyte MN studies should be acceptable if dosing is co...
