Soleimani, Esmaeel
Published in
Reviews in Analytical Chemistry
Benzene, toluene, ethylbenzene, and xylene (BTEX) are a group of volatile organic compounds that human exposure to them may result in the development of some diseases, including cancer. Biological monitoring plays an important role in exposure assessment of workers occupationally exposed to chemicals. Several metabolites have been proposed for biol...
Shen, ZheLun Yu, QingQing Li, YangLei Bao, YiQi Lu, Hong
Published in
Drug and chemical toxicology
Acyclovir (ACV) is a nucleoside antivirus-free agent that was developed and marketed by Burroughs Well-come of the United States. Renal damage from ACV has been a major factor limiting its clinical application. Thus, the renal toxicity mechanism of ACV requires systematic study. In our previous study, we speculated that the nephrotoxicity of ACV ma...
Huet, Raul Johanson, Gunnar
Published in
Pharmaceutics
(1) Background: Inhalant abuse and misuse are still widespread problems. 1,1-Difluoroethane abuse is reported to be potentially fatal and to cause acute and chronic adverse health effects. Lab testing for difluoroethane is seldom done, partly because the maximum detection time (MDT) is unknown. We sought to reliably estimate the MDT of difluoroetha...
Rejeb, Roua Baere, Siegrid De Devreese, Mathias Ducatelle, Richard Croubels, Siska Ayed, Madiha Hadj Ghorbal, Achraf Antonissen, Gunther
Published in
Toxins
The goal of this study was to investigate the toxicokinetic characteristics of aflatoxin G1 (AFG1) in broiler chickens and the effect of calcination of a Tunisian montmorillonite clay on the in vivo absorption of AFG1. In this study, broiler chickens were randomly distributed into four groups of 10 animals. Group 1 was administered AFG1 (2 mg/kg bo...
Waidyanatha, Suramya Black, Sherry R Croutch, Claire R Collins, Bradley J Silinski, Melanie A R Kerns, Season Sutherland, Vicki Robinson, Veronica G Aillon, Kristin Fernando, Reshan A
...
Published in
Xenobiotica; the fate of foreign compounds in biological systems
We investigated the plasma toxicokinetic behavior of free (parent) and total (parent and conjugated forms) of bisphenol S (BPS) and bisphenol AF (BPAF) in plasma of adult male rats and mice following exposure via feed for 7 days to BPS (338, 1125, and 3375 ppm) or BPAF (338, 1125, and 3750 ppm). In rats, the exposure concentration-normalized maximu...
Yamamoto, Megumi Yanagisawa, Rie Sakai, Atsushi Mogi, Masaki Shuto, Satoshi Shudo, Masachika Kashiwagi, Hazuki Kudo, Megumi Nakamura, Masaaki Sakamoto, Mineshi
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Published in
Journal of applied toxicology : JAT
We compared the toxicokinetics of methylmercury (MeHg) in KK-Ay type 2 diabetic mice and C57BL/6J mice to evaluate how metabolic changes associated with diabetes affect MeHg toxicokinetics. A single dose of MeHg (0.2, 1, or 5 mg mercury/kg) was administered orally to 12-week-old KK-Ay and C57BL/6J male mice. Total mercury concentrations in plasma, ...
Knudsen, Cecilie Casewell, Nicholas R. Lomonte, Bruno Gutiérrez, José María Vaiyapuri, Sakthivel Laustsen, Andreas H.
Published in
Toxins
In the field of antivenom research, development, and manufacture, it is often advised to follow the World Health Organization’s (WHO) guidelines for the production, control, and regulation of snake antivenom immunoglobulins, which recommend the use of preincubation assays to assess the efficacy of snakebite therapeutics. In these assays, venom and ...
Connolly, Alison Coggins, Marie A. Koch, Holger M.
Published in
Toxics
Glyphosate continues to attract controversial debate following the International Agency for Research on Cancer carcinogenicity classification in 2015. Despite its ubiquitous presence in our environment, there remains a dearth of data on human exposure to both glyphosate and its main biodegradation product aminomethylphosphonic (AMPA). Herein, we re...
Elsamadisi, Pansy Sclafani, Alyssa Eche, Ifeoma Mary
Published in
Journal of pharmacy practice
A case of a nortriptyline overdose complicated by delayed ventricular arrhythmias necessitating prolonged sodium bicarbonate infusion is presented, along with a review of tricyclic antidepressant (TCA) toxicology and key concepts for massive overdose management. A 61-year-old man presented after an intentional nortriptyline overdose with a possible...
Campbell Jr, Jerry L Gentry, P Robinan Clewell III, Harvey J Andersen, Melvin E
Published in
Toxicological Sciences
Although formaldehyde is a normal constituent of tissues, lifetime inhalation exposures at 6 h/day, 5 days/week at concentrations ≥6 ppm caused a nonlinear increase in nasal tumors in rats with incidence reaching close to 50% at 15 ppm. Studies with heavy isotope labeled [13CD2]-formaldehyde permit quantification of both the mass-labeled exogenous ...
