Chemicals applied in products, such as food products, pharmaceuticals or cosmetics, create great benefits in society while posing risks to human health and the quality of the environment. To control those risks, it is mandatory to perform risk assessments of chemicals which require information on their hazardous properties. To meet these informatio...
This PhD thesis aimed to provide additional evidence to demonstrate the potential of an integrated testing strategy using in vitro assays with physiologically based kinetic (PBK) modeling based-reverse dosimetry to predict in vivo toxicity without animal testing. Kidney toxicity was chosen as the toxicity endpoint and aristolochic acids (AAs) were ...
Because of the improved survival rate, both short term and long term adverse effects of breast cancer treatment have become increasingly important. Body weight and body composition before, during, and after chemotherapy may influence side effects during treatment and survival. The aims of this thesis were to assess among stage I-IIIB breast cancer ...
The production of nanoparticles (NPs) has increased in the last decades and the number of products in which NPs are being incorporated is still growing. The rapid increase of nanotechnology has several benefits for society, yet there is an increasing concern that exposure to NPs may result in significant adverse health effects. Since NPs are incorp...
Owing to their small sizes, nanoparticles (NPs) exhibit completely different and novel characteristics compared to their bulk counterparts of the same chemical composition. These novel properties include increased reactivity due to large specific surface area, fluorescence and colour changes, increased biological barrier crossings and increased mat...
Determination of safe human exposure levels of chemicals in toxicological risk assessments largely relies on animal toxicity data. In these toxicity studies, the highest number of animals are used for reproductive and developmental toxicity testing. Because of economic and ethical reasons, there is large interest in the development of in vitro and/...
Momenteel vinden in verschillende gemeenten discussies plaats over de veiligheidszones rond fruitteeltbedrijven als gevolg van bespuitingen en de blootstelling van te bouwen woningen dichtbij de boomgaard. In deze rapportage wordt voor de blootstelling vanuit fruitteelt bespuitingen een overzicht gegeven van de drift bij standaard en drift beperken...
Selenium in the form of selenate or selenite in wastewater needs to be removed due to its potential toxicity in the environment. Also, selenium is a valuable element that is used in several industries and current selenium resources are likely to be exhausted in less than 50 years. Waste streams containing selenium can therefore be used as a source ...
